Putative diagnosis of neuromuscular and vascular hamartoma: 2 cases in dogs and review of the veterinary literature
Neuromuscular and vascular hamartoma (NMVH) is an infrequent gastrointestinal lesion described in human and veterinary medical literature. The histologic features of this entity are haphazardly arranged fascicles of smooth muscle, nerve fibers, scattered ganglion cells, and hemangiomatous blood vess...
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| Veröffentlicht in: | Journal of veterinary diagnostic investigation 2024-11, Vol.36 (6), p.879-885 |
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| container_title | Journal of veterinary diagnostic investigation |
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| creator | Barrantes Murillo, Daniel Felipe Negrão Watanabe, Tatiane Terumi Brinker, Emily J. Book, Bradley P. Dvorak, Laura Huang, Linda |
| description | Neuromuscular and vascular hamartoma (NMVH) is an infrequent gastrointestinal lesion described in human and veterinary medical literature. The histologic features of this entity are haphazardly arranged fascicles of smooth muscle, nerve fibers, scattered ganglion cells, and hemangiomatous blood vessels. Here we describe 2 putative cases of NMVH in a 1.7-y-old, intact female Anatolian mixed-breed dog and a 4-mo-old intact male Akita dog. Both animals had gastrointestinal clinical signs, including hematochezia, and on exploratory laparotomy, intussusception was confirmed. Histologic examination confirmed NMVH within the cecal wall in both cases using a panel of immunohistochemical (IHC) markers for vascular structures (CD31), smooth muscle (alpha–smooth muscle actin [α-SMA]), and nerves (glial fibrillary acidic protein [GFAP] and S100). The complete surgical excision of the lesion in both animals was considered curative without persistent clinical signs 14 mo and 12 mo, respectively, after surgery. |
| doi_str_mv | 10.1177/10406387241266862 |
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The histologic features of this entity are haphazardly arranged fascicles of smooth muscle, nerve fibers, scattered ganglion cells, and hemangiomatous blood vessels. Here we describe 2 putative cases of NMVH in a 1.7-y-old, intact female Anatolian mixed-breed dog and a 4-mo-old intact male Akita dog. Both animals had gastrointestinal clinical signs, including hematochezia, and on exploratory laparotomy, intussusception was confirmed. Histologic examination confirmed NMVH within the cecal wall in both cases using a panel of immunohistochemical (IHC) markers for vascular structures (CD31), smooth muscle (alpha–smooth muscle actin [α-SMA]), and nerves (glial fibrillary acidic protein [GFAP] and S100). The complete surgical excision of the lesion in both animals was considered curative without persistent clinical signs 14 mo and 12 mo, respectively, after surgery.</description><identifier>ISSN: 1040-6387</identifier><identifier>ISSN: 1943-4936</identifier><identifier>EISSN: 1943-4936</identifier><identifier>DOI: 10.1177/10406387241266862</identifier><identifier>PMID: 39101591</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>actin ; Animals ; blood ; Dog Diseases - diagnosis ; Dog Diseases - pathology ; Dog Diseases - surgery ; Dogs ; excision ; Female ; females ; ganglia ; gastrointestinal system ; hamartoma ; Hamartoma - diagnosis ; Hamartoma - pathology ; Hamartoma - veterinary ; humans ; immunohistochemistry ; laparotomy ; Male ; males ; mixed breeds ; muscles ; nerve tissue ; Neuromuscular Diseases - diagnosis ; Neuromuscular Diseases - pathology ; Neuromuscular Diseases - veterinary ; smooth muscle ; Turkey (country)</subject><ispartof>Journal of veterinary diagnostic investigation, 2024-11, Vol.36 (6), p.879-885</ispartof><rights>2024 The Author(s)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c255t-8a9349ce4c51f8b1e447d1d1ba240bb53ef0bf4dd46fecc6cfcba9a1c91b10e23</cites><orcidid>0000-0002-0744-3774 ; 0000-0002-7582-3090</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/10406387241266862$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/10406387241266862$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39101591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barrantes Murillo, Daniel Felipe</creatorcontrib><creatorcontrib>Negrão Watanabe, Tatiane Terumi</creatorcontrib><creatorcontrib>Brinker, Emily J.</creatorcontrib><creatorcontrib>Book, Bradley P.</creatorcontrib><creatorcontrib>Dvorak, Laura</creatorcontrib><creatorcontrib>Huang, Linda</creatorcontrib><title>Putative diagnosis of neuromuscular and vascular hamartoma: 2 cases in dogs and review of the veterinary literature</title><title>Journal of veterinary diagnostic investigation</title><addtitle>J Vet Diagn Invest</addtitle><description>Neuromuscular and vascular hamartoma (NMVH) is an infrequent gastrointestinal lesion described in human and veterinary medical literature. The histologic features of this entity are haphazardly arranged fascicles of smooth muscle, nerve fibers, scattered ganglion cells, and hemangiomatous blood vessels. Here we describe 2 putative cases of NMVH in a 1.7-y-old, intact female Anatolian mixed-breed dog and a 4-mo-old intact male Akita dog. Both animals had gastrointestinal clinical signs, including hematochezia, and on exploratory laparotomy, intussusception was confirmed. Histologic examination confirmed NMVH within the cecal wall in both cases using a panel of immunohistochemical (IHC) markers for vascular structures (CD31), smooth muscle (alpha–smooth muscle actin [α-SMA]), and nerves (glial fibrillary acidic protein [GFAP] and S100). The complete surgical excision of the lesion in both animals was considered curative without persistent clinical signs 14 mo and 12 mo, respectively, after surgery.</description><subject>actin</subject><subject>Animals</subject><subject>blood</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - pathology</subject><subject>Dog Diseases - surgery</subject><subject>Dogs</subject><subject>excision</subject><subject>Female</subject><subject>females</subject><subject>ganglia</subject><subject>gastrointestinal system</subject><subject>hamartoma</subject><subject>Hamartoma - diagnosis</subject><subject>Hamartoma - pathology</subject><subject>Hamartoma - veterinary</subject><subject>humans</subject><subject>immunohistochemistry</subject><subject>laparotomy</subject><subject>Male</subject><subject>males</subject><subject>mixed breeds</subject><subject>muscles</subject><subject>nerve tissue</subject><subject>Neuromuscular Diseases - diagnosis</subject><subject>Neuromuscular Diseases - pathology</subject><subject>Neuromuscular Diseases - veterinary</subject><subject>smooth muscle</subject><subject>Turkey (country)</subject><issn>1040-6387</issn><issn>1943-4936</issn><issn>1943-4936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EoqXtH8Cl8pFLFo8_kri3qiofUiU4wDmaOJOtqyQudryo_z1edukFCU7zRvObd3iPsbcgNgBN8x6EFrVqG6lB1nVbyxfsFKxWlbaqfll0uVd74IS9SelBCCNNA6_ZibIgwFg4ZelrXnH1O-KDx-0Skk88jHyhHMOck8sTRo7LwHd4XO5xxriGGa-45A4TJe4XPoRt-s1F2nn6ufdY74nvaKXoF4xPfPJF4pojnbNXI06JLo7zjH3_cPvt5lN19-Xj55vru8pJY9aqRau0daSdgbHtgbRuBhigR6lF3xtFo-hHPQy6Hsm52o2uR4vgLPQgSKoz9u7g-xjDj0xp7WafHE0TLhRy6hQY1WqhS2L_RUXbGmNlAwWFA-piSCnS2D1GXyJ56kB0-1q6v2opP5dH-9zPNDx__OmhAJsDkHBL3UPIcSnJ_MPxFyAllxA</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Barrantes Murillo, Daniel Felipe</creator><creator>Negrão Watanabe, Tatiane Terumi</creator><creator>Brinker, Emily J.</creator><creator>Book, Bradley P.</creator><creator>Dvorak, Laura</creator><creator>Huang, Linda</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-0744-3774</orcidid><orcidid>https://orcid.org/0000-0002-7582-3090</orcidid></search><sort><creationdate>202411</creationdate><title>Putative diagnosis of neuromuscular and vascular hamartoma: 2 cases in dogs and review of the veterinary literature</title><author>Barrantes Murillo, Daniel Felipe ; Negrão Watanabe, Tatiane Terumi ; Brinker, Emily J. ; Book, Bradley P. ; Dvorak, Laura ; Huang, Linda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c255t-8a9349ce4c51f8b1e447d1d1ba240bb53ef0bf4dd46fecc6cfcba9a1c91b10e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>actin</topic><topic>Animals</topic><topic>blood</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - pathology</topic><topic>Dog Diseases - surgery</topic><topic>Dogs</topic><topic>excision</topic><topic>Female</topic><topic>females</topic><topic>ganglia</topic><topic>gastrointestinal system</topic><topic>hamartoma</topic><topic>Hamartoma - diagnosis</topic><topic>Hamartoma - pathology</topic><topic>Hamartoma - veterinary</topic><topic>humans</topic><topic>immunohistochemistry</topic><topic>laparotomy</topic><topic>Male</topic><topic>males</topic><topic>mixed breeds</topic><topic>muscles</topic><topic>nerve tissue</topic><topic>Neuromuscular Diseases - diagnosis</topic><topic>Neuromuscular Diseases - pathology</topic><topic>Neuromuscular Diseases - veterinary</topic><topic>smooth muscle</topic><topic>Turkey (country)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barrantes Murillo, Daniel Felipe</creatorcontrib><creatorcontrib>Negrão Watanabe, Tatiane Terumi</creatorcontrib><creatorcontrib>Brinker, Emily J.</creatorcontrib><creatorcontrib>Book, Bradley P.</creatorcontrib><creatorcontrib>Dvorak, Laura</creatorcontrib><creatorcontrib>Huang, Linda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of veterinary diagnostic investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barrantes Murillo, Daniel Felipe</au><au>Negrão Watanabe, Tatiane Terumi</au><au>Brinker, Emily J.</au><au>Book, Bradley P.</au><au>Dvorak, Laura</au><au>Huang, Linda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Putative diagnosis of neuromuscular and vascular hamartoma: 2 cases in dogs and review of the veterinary literature</atitle><jtitle>Journal of veterinary diagnostic investigation</jtitle><addtitle>J Vet Diagn Invest</addtitle><date>2024-11</date><risdate>2024</risdate><volume>36</volume><issue>6</issue><spage>879</spage><epage>885</epage><pages>879-885</pages><issn>1040-6387</issn><issn>1943-4936</issn><eissn>1943-4936</eissn><abstract>Neuromuscular and vascular hamartoma (NMVH) is an infrequent gastrointestinal lesion described in human and veterinary medical literature. The histologic features of this entity are haphazardly arranged fascicles of smooth muscle, nerve fibers, scattered ganglion cells, and hemangiomatous blood vessels. Here we describe 2 putative cases of NMVH in a 1.7-y-old, intact female Anatolian mixed-breed dog and a 4-mo-old intact male Akita dog. Both animals had gastrointestinal clinical signs, including hematochezia, and on exploratory laparotomy, intussusception was confirmed. Histologic examination confirmed NMVH within the cecal wall in both cases using a panel of immunohistochemical (IHC) markers for vascular structures (CD31), smooth muscle (alpha–smooth muscle actin [α-SMA]), and nerves (glial fibrillary acidic protein [GFAP] and S100). The complete surgical excision of the lesion in both animals was considered curative without persistent clinical signs 14 mo and 12 mo, respectively, after surgery.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>39101591</pmid><doi>10.1177/10406387241266862</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0744-3774</orcidid><orcidid>https://orcid.org/0000-0002-7582-3090</orcidid></addata></record> |
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| subjects | actin Animals blood Dog Diseases - diagnosis Dog Diseases - pathology Dog Diseases - surgery Dogs excision Female females ganglia gastrointestinal system hamartoma Hamartoma - diagnosis Hamartoma - pathology Hamartoma - veterinary humans immunohistochemistry laparotomy Male males mixed breeds muscles nerve tissue Neuromuscular Diseases - diagnosis Neuromuscular Diseases - pathology Neuromuscular Diseases - veterinary smooth muscle Turkey (country) |
| title | Putative diagnosis of neuromuscular and vascular hamartoma: 2 cases in dogs and review of the veterinary literature |
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