Patterning and folding of intestinal villi by active mesenchymal dewetting

Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that enable nutrient absorption. However, the molecular and mechanical processes driving villus morphogenesis re...

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Veröffentlicht in:	Cell 2024-06, Vol.187 (12), p.3072-3089.e20
Hauptverfasser:	Huycke, Tyler R., Häkkinen, Teemu J., Miyazaki, Hikaru, Srivastava, Vasudha, Barruet, Emilie, McGinnis, Christopher S., Kalantari, Ali, Cornwall-Scoones, Jake, Vaka, Dedeepya, Zhu, Qin, Jo, Hyunil, Oria, Roger, Weaver, Valerie M., DeGrado, William F., Thomson, Matt, Garikipati, Krishna, Boffelli, Dario, Klein, Ophir D., Gartner, Zev J.
Format:	Artikel
Sprache:	eng
Schlagworte:	active fluids biophysics Cahn-Hilliard cell adhesion development extracellular matrix intestinal mucosa liquids morphogenesis myosin nutrient uptake patterning phase separation self-organization villi
Online-Zugang:	Volltext
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