The mitigating role of lysophospholipids in hepatic lipid metabolism and intestinal immunity in juvenile black seabream (Acanthopagrus schlegelii) fed a high-fat diet
An 8-week feeding experiment investigated the effects of lysophospholipids (LP) on growth performance, hepatic lipid metabolism, intestinal immunity and antioxidation in juvenile black seabream (Acanthopagrus schlegelii) (initial weight 4.60 ± 0.01 g) on a high-fat diet. Five experimental diets were...
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| creator | Zhu, Jiayun Gu, Yixin Shen, Yuedong Zhao, Wenli Bao, Yangguang Cheng, Hao Zhi, Xinyan Hu, Xinyu Monroig, Óscar Zhu, Tingting Sun, Peng Zhou, Qicun Jin, Min |
| description | An 8-week feeding experiment investigated the effects of lysophospholipids (LP) on growth performance, hepatic lipid metabolism, intestinal immunity and antioxidation in juvenile black seabream (Acanthopagrus schlegelii) (initial weight 4.60 ± 0.01 g) on a high-fat diet. Five experimental diets were established: normal fat diet (13 %, CON), high-fat diet (18 %, HFD) and HFD with different levels of LP (0.05 %, 0.1 %, and 0.2 %). The results indicated that dietary LP had no impact on the specific growth rate and survival rate of juvenile black seabream (P > 0.05), while 0.2 %LP supplementation reduced the intraperitoneal fat ratio (IPF) (P |
| doi_str_mv | 10.1016/j.aquaculture.2024.741718 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153837686</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0044848624011803</els_id><sourcerecordid>3153837686</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-836d1232405471b85c7762abcc0641463f80b8a993bc3082522bd533f0c0ca153</originalsourceid><addsrcrecordid>eNqNkb1u3DAQhFU4QBwn78B0TqEzfySKVxqHJDZgII1TEytqJe2Z-jFJGbgXynOGl0uRMsVigd2ZDxhMUXwWfCe40HfHHbxu4DaftoA7yWW1ayrRCHNVXHNeVaWpjH5ffIjxyDnXuhbXxa_nEdlEiQZINA8sLB7Z0jN_iss6LjGPp5W6yGhmI65Z5difC5swQZu_cWIwd_mfMGYGeEbTtM2UTmfPcXvDmTK09eBeWERoA8LEbu8dzGlcVhjCFll0o8cBPdEX1mPHgI00jGUPiXWE6WPxrgcf8dPffVP8_Pb1-fBQPv34_ni4fyqdlCaVRulOSCUrXleNaE3tmkZLaJ3juhKVVr3hrYH9XrVOcSNrKduuVqrnjjsQtbopbi_cNSyvW85jJ4oOvYcZly1alTVGNdroLN1fpC4sMQbs7RpognCygttzH_Zo_-nDnvuwlz6y93DxYs7yRhhsdISzw44CumS7hf6D8hs2ip94</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3153837686</pqid></control><display><type>article</type><title>The mitigating role of lysophospholipids in hepatic lipid metabolism and intestinal immunity in juvenile black seabream (Acanthopagrus schlegelii) fed a high-fat diet</title><source>Elsevier ScienceDirect Journals</source><creator>Zhu, Jiayun ; Gu, Yixin ; Shen, Yuedong ; Zhao, Wenli ; Bao, Yangguang ; Cheng, Hao ; Zhi, Xinyan ; Hu, Xinyu ; Monroig, Óscar ; Zhu, Tingting ; Sun, Peng ; Zhou, Qicun ; Jin, Min</creator><creatorcontrib>Zhu, Jiayun ; Gu, Yixin ; Shen, Yuedong ; Zhao, Wenli ; Bao, Yangguang ; Cheng, Hao ; Zhi, Xinyan ; Hu, Xinyu ; Monroig, Óscar ; Zhu, Tingting ; Sun, Peng ; Zhou, Qicun ; Jin, Min</creatorcontrib><description><![CDATA[An 8-week feeding experiment investigated the effects of lysophospholipids (LP) on growth performance, hepatic lipid metabolism, intestinal immunity and antioxidation in juvenile black seabream (Acanthopagrus schlegelii) (initial weight 4.60 ± 0.01 g) on a high-fat diet. Five experimental diets were established: normal fat diet (13 %, CON), high-fat diet (18 %, HFD) and HFD with different levels of LP (0.05 %, 0.1 %, and 0.2 %). The results indicated that dietary LP had no impact on the specific growth rate and survival rate of juvenile black seabream (P > 0.05), while 0.2 %LP supplementation reduced the intraperitoneal fat ratio (IPF) (P < 0.05). Dietary 0.1 % and 0.2 %LP supplementation reduced the total lipid content and the size and number of lipid droplets in the liver (P < 0.05). The diets supplemented with LP reduced the contents of TG and LDL-C in the serum (P < 0.05), without affecting T-CHO and HDL-C (P > 0.05). The expression of lipid transport genes including apoa, apob, fatp1, and fatp4, were markedly up-regulated with increased dietary LP supplementation (P < 0.05). Moreover, dietary 0.2 %LP supplementation notably increased mRNA expression levels of scarb1, ffar3, acsl5 and glp-1 in the intestine (P < 0.05). Dietary LP notably down-regulated the mRNA expression of genes related to the lipogenesis pathway including fas, aco and srebp-1c, while up-regulating mRNA expression of lipogenesis-related genes including cpt1α, lpl, and pparα (P < 0.05). Additionally, dietary 0.2 %LP supplementation notably increased total antioxidant capacity in the intestine and up-regulated expression levels of intestinal antioxidant genes, including mn sod, cu-zn sod, gpx, and cat (P < 0.05), fish fed diets with 0.2 %LP down-regulation of pro-inflammatory genes, including tnfα and nf-κb, and up-regulation of anti-inflammatory factors, tgfβ-1, il-10 and tight-junction protein genes including (oclna, cldni, cldn3, and tjp1b) in the intestine (P < 0.05). In conclusion, dietary LP improved intestinal fatty acid transport and liver lipolysis, alleviating intestinal oxidative damage and inflammatory reactions caused by HFD in black seabream.
•Lysophospholipids (LP) elevates hepatic lipolysis and reduces hepatic lipid content.•LP supplementation upregulates intestinal lipid transport and GLP-1 genes.•0.2 % LP enhances antioxidant genes and decreases oxidative damage markers in the intestine.•0.2 % LP decreases intestinal inflammation and improves barrier function.]]></description><identifier>ISSN: 0044-8486</identifier><identifier>DOI: 10.1016/j.aquaculture.2024.741718</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Acanthopagrus schlegelii schlegelii ; antioxidant activity ; antioxidants ; aquaculture ; Black seabream ; blood serum ; fatty acids ; fish ; gene expression ; Glucagon-like peptide-1 ; growth performance ; high fat diet ; Immune response ; immunity ; interleukin-10 ; intestines ; juveniles ; lipid content ; Lipid metabolism ; lipogenesis ; lipolysis ; liver ; Lysophospholipids ; specific growth rate ; survival rate</subject><ispartof>Aquaculture, 2025-01, Vol.595, p.741718, Article 741718</ispartof><rights>2024 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-836d1232405471b85c7762abcc0641463f80b8a993bc3082522bd533f0c0ca153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0044848624011803$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Zhu, Jiayun</creatorcontrib><creatorcontrib>Gu, Yixin</creatorcontrib><creatorcontrib>Shen, Yuedong</creatorcontrib><creatorcontrib>Zhao, Wenli</creatorcontrib><creatorcontrib>Bao, Yangguang</creatorcontrib><creatorcontrib>Cheng, Hao</creatorcontrib><creatorcontrib>Zhi, Xinyan</creatorcontrib><creatorcontrib>Hu, Xinyu</creatorcontrib><creatorcontrib>Monroig, Óscar</creatorcontrib><creatorcontrib>Zhu, Tingting</creatorcontrib><creatorcontrib>Sun, Peng</creatorcontrib><creatorcontrib>Zhou, Qicun</creatorcontrib><creatorcontrib>Jin, Min</creatorcontrib><title>The mitigating role of lysophospholipids in hepatic lipid metabolism and intestinal immunity in juvenile black seabream (Acanthopagrus schlegelii) fed a high-fat diet</title><title>Aquaculture</title><description><![CDATA[An 8-week feeding experiment investigated the effects of lysophospholipids (LP) on growth performance, hepatic lipid metabolism, intestinal immunity and antioxidation in juvenile black seabream (Acanthopagrus schlegelii) (initial weight 4.60 ± 0.01 g) on a high-fat diet. Five experimental diets were established: normal fat diet (13 %, CON), high-fat diet (18 %, HFD) and HFD with different levels of LP (0.05 %, 0.1 %, and 0.2 %). The results indicated that dietary LP had no impact on the specific growth rate and survival rate of juvenile black seabream (P > 0.05), while 0.2 %LP supplementation reduced the intraperitoneal fat ratio (IPF) (P < 0.05). Dietary 0.1 % and 0.2 %LP supplementation reduced the total lipid content and the size and number of lipid droplets in the liver (P < 0.05). The diets supplemented with LP reduced the contents of TG and LDL-C in the serum (P < 0.05), without affecting T-CHO and HDL-C (P > 0.05). The expression of lipid transport genes including apoa, apob, fatp1, and fatp4, were markedly up-regulated with increased dietary LP supplementation (P < 0.05). Moreover, dietary 0.2 %LP supplementation notably increased mRNA expression levels of scarb1, ffar3, acsl5 and glp-1 in the intestine (P < 0.05). Dietary LP notably down-regulated the mRNA expression of genes related to the lipogenesis pathway including fas, aco and srebp-1c, while up-regulating mRNA expression of lipogenesis-related genes including cpt1α, lpl, and pparα (P < 0.05). Additionally, dietary 0.2 %LP supplementation notably increased total antioxidant capacity in the intestine and up-regulated expression levels of intestinal antioxidant genes, including mn sod, cu-zn sod, gpx, and cat (P < 0.05), fish fed diets with 0.2 %LP down-regulation of pro-inflammatory genes, including tnfα and nf-κb, and up-regulation of anti-inflammatory factors, tgfβ-1, il-10 and tight-junction protein genes including (oclna, cldni, cldn3, and tjp1b) in the intestine (P < 0.05). In conclusion, dietary LP improved intestinal fatty acid transport and liver lipolysis, alleviating intestinal oxidative damage and inflammatory reactions caused by HFD in black seabream.
•Lysophospholipids (LP) elevates hepatic lipolysis and reduces hepatic lipid content.•LP supplementation upregulates intestinal lipid transport and GLP-1 genes.•0.2 % LP enhances antioxidant genes and decreases oxidative damage markers in the intestine.•0.2 % LP decreases intestinal inflammation and improves barrier function.]]></description><subject>Acanthopagrus schlegelii schlegelii</subject><subject>antioxidant activity</subject><subject>antioxidants</subject><subject>aquaculture</subject><subject>Black seabream</subject><subject>blood serum</subject><subject>fatty acids</subject><subject>fish</subject><subject>gene expression</subject><subject>Glucagon-like peptide-1</subject><subject>growth performance</subject><subject>high fat diet</subject><subject>Immune response</subject><subject>immunity</subject><subject>interleukin-10</subject><subject>intestines</subject><subject>juveniles</subject><subject>lipid content</subject><subject>Lipid metabolism</subject><subject>lipogenesis</subject><subject>lipolysis</subject><subject>liver</subject><subject>Lysophospholipids</subject><subject>specific growth rate</subject><subject>survival rate</subject><issn>0044-8486</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNqNkb1u3DAQhFU4QBwn78B0TqEzfySKVxqHJDZgII1TEytqJe2Z-jFJGbgXynOGl0uRMsVigd2ZDxhMUXwWfCe40HfHHbxu4DaftoA7yWW1ayrRCHNVXHNeVaWpjH5ffIjxyDnXuhbXxa_nEdlEiQZINA8sLB7Z0jN_iss6LjGPp5W6yGhmI65Z5difC5swQZu_cWIwd_mfMGYGeEbTtM2UTmfPcXvDmTK09eBeWERoA8LEbu8dzGlcVhjCFll0o8cBPdEX1mPHgI00jGUPiXWE6WPxrgcf8dPffVP8_Pb1-fBQPv34_ni4fyqdlCaVRulOSCUrXleNaE3tmkZLaJ3juhKVVr3hrYH9XrVOcSNrKduuVqrnjjsQtbopbi_cNSyvW85jJ4oOvYcZly1alTVGNdroLN1fpC4sMQbs7RpognCygttzH_Zo_-nDnvuwlz6y93DxYs7yRhhsdISzw44CumS7hf6D8hs2ip94</recordid><startdate>20250130</startdate><enddate>20250130</enddate><creator>Zhu, Jiayun</creator><creator>Gu, Yixin</creator><creator>Shen, Yuedong</creator><creator>Zhao, Wenli</creator><creator>Bao, Yangguang</creator><creator>Cheng, Hao</creator><creator>Zhi, Xinyan</creator><creator>Hu, Xinyu</creator><creator>Monroig, Óscar</creator><creator>Zhu, Tingting</creator><creator>Sun, Peng</creator><creator>Zhou, Qicun</creator><creator>Jin, Min</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20250130</creationdate><title>The mitigating role of lysophospholipids in hepatic lipid metabolism and intestinal immunity in juvenile black seabream (Acanthopagrus schlegelii) fed a high-fat diet</title><author>Zhu, Jiayun ; Gu, Yixin ; Shen, Yuedong ; Zhao, Wenli ; Bao, Yangguang ; Cheng, Hao ; Zhi, Xinyan ; Hu, Xinyu ; Monroig, Óscar ; Zhu, Tingting ; Sun, Peng ; Zhou, Qicun ; Jin, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-836d1232405471b85c7762abcc0641463f80b8a993bc3082522bd533f0c0ca153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Acanthopagrus schlegelii schlegelii</topic><topic>antioxidant activity</topic><topic>antioxidants</topic><topic>aquaculture</topic><topic>Black seabream</topic><topic>blood serum</topic><topic>fatty acids</topic><topic>fish</topic><topic>gene expression</topic><topic>Glucagon-like peptide-1</topic><topic>growth performance</topic><topic>high fat diet</topic><topic>Immune response</topic><topic>immunity</topic><topic>interleukin-10</topic><topic>intestines</topic><topic>juveniles</topic><topic>lipid content</topic><topic>Lipid metabolism</topic><topic>lipogenesis</topic><topic>lipolysis</topic><topic>liver</topic><topic>Lysophospholipids</topic><topic>specific growth rate</topic><topic>survival rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Jiayun</creatorcontrib><creatorcontrib>Gu, Yixin</creatorcontrib><creatorcontrib>Shen, Yuedong</creatorcontrib><creatorcontrib>Zhao, Wenli</creatorcontrib><creatorcontrib>Bao, Yangguang</creatorcontrib><creatorcontrib>Cheng, Hao</creatorcontrib><creatorcontrib>Zhi, Xinyan</creatorcontrib><creatorcontrib>Hu, Xinyu</creatorcontrib><creatorcontrib>Monroig, Óscar</creatorcontrib><creatorcontrib>Zhu, Tingting</creatorcontrib><creatorcontrib>Sun, Peng</creatorcontrib><creatorcontrib>Zhou, Qicun</creatorcontrib><creatorcontrib>Jin, Min</creatorcontrib><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Aquaculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Jiayun</au><au>Gu, Yixin</au><au>Shen, Yuedong</au><au>Zhao, Wenli</au><au>Bao, Yangguang</au><au>Cheng, Hao</au><au>Zhi, Xinyan</au><au>Hu, Xinyu</au><au>Monroig, Óscar</au><au>Zhu, Tingting</au><au>Sun, Peng</au><au>Zhou, Qicun</au><au>Jin, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mitigating role of lysophospholipids in hepatic lipid metabolism and intestinal immunity in juvenile black seabream (Acanthopagrus schlegelii) fed a high-fat diet</atitle><jtitle>Aquaculture</jtitle><date>2025-01-30</date><risdate>2025</risdate><volume>595</volume><spage>741718</spage><pages>741718-</pages><artnum>741718</artnum><issn>0044-8486</issn><abstract><![CDATA[An 8-week feeding experiment investigated the effects of lysophospholipids (LP) on growth performance, hepatic lipid metabolism, intestinal immunity and antioxidation in juvenile black seabream (Acanthopagrus schlegelii) (initial weight 4.60 ± 0.01 g) on a high-fat diet. Five experimental diets were established: normal fat diet (13 %, CON), high-fat diet (18 %, HFD) and HFD with different levels of LP (0.05 %, 0.1 %, and 0.2 %). The results indicated that dietary LP had no impact on the specific growth rate and survival rate of juvenile black seabream (P > 0.05), while 0.2 %LP supplementation reduced the intraperitoneal fat ratio (IPF) (P < 0.05). Dietary 0.1 % and 0.2 %LP supplementation reduced the total lipid content and the size and number of lipid droplets in the liver (P < 0.05). The diets supplemented with LP reduced the contents of TG and LDL-C in the serum (P < 0.05), without affecting T-CHO and HDL-C (P > 0.05). The expression of lipid transport genes including apoa, apob, fatp1, and fatp4, were markedly up-regulated with increased dietary LP supplementation (P < 0.05). Moreover, dietary 0.2 %LP supplementation notably increased mRNA expression levels of scarb1, ffar3, acsl5 and glp-1 in the intestine (P < 0.05). Dietary LP notably down-regulated the mRNA expression of genes related to the lipogenesis pathway including fas, aco and srebp-1c, while up-regulating mRNA expression of lipogenesis-related genes including cpt1α, lpl, and pparα (P < 0.05). Additionally, dietary 0.2 %LP supplementation notably increased total antioxidant capacity in the intestine and up-regulated expression levels of intestinal antioxidant genes, including mn sod, cu-zn sod, gpx, and cat (P < 0.05), fish fed diets with 0.2 %LP down-regulation of pro-inflammatory genes, including tnfα and nf-κb, and up-regulation of anti-inflammatory factors, tgfβ-1, il-10 and tight-junction protein genes including (oclna, cldni, cldn3, and tjp1b) in the intestine (P < 0.05). In conclusion, dietary LP improved intestinal fatty acid transport and liver lipolysis, alleviating intestinal oxidative damage and inflammatory reactions caused by HFD in black seabream.
•Lysophospholipids (LP) elevates hepatic lipolysis and reduces hepatic lipid content.•LP supplementation upregulates intestinal lipid transport and GLP-1 genes.•0.2 % LP enhances antioxidant genes and decreases oxidative damage markers in the intestine.•0.2 % LP decreases intestinal inflammation and improves barrier function.]]></abstract><pub>Elsevier B.V</pub><doi>10.1016/j.aquaculture.2024.741718</doi></addata></record> |
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| subjects | Acanthopagrus schlegelii schlegelii antioxidant activity antioxidants aquaculture Black seabream blood serum fatty acids fish gene expression Glucagon-like peptide-1 growth performance high fat diet Immune response immunity interleukin-10 intestines juveniles lipid content Lipid metabolism lipogenesis lipolysis liver Lysophospholipids specific growth rate survival rate |
| title | The mitigating role of lysophospholipids in hepatic lipid metabolism and intestinal immunity in juvenile black seabream (Acanthopagrus schlegelii) fed a high-fat diet |
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