Rapid Characterization of the Potential Active of Sinomenine in Rats by Ultra‐High‐Performance Liquid Chromatography‐Quadrupole‐Exactive Orbitrap Mass Spectrometry and Molecular Docking

ABSTRACT Sinomenium acutum (Thunb.) Rehd. et Wils is widely used in the treatment of rheumatoid arthritis, with its alkaloid compound sinomenine (SIN) being renowned for its significant anti‐inflammatory properties. However, despite its widespread application, the in vivo anti‐inflammatory mechanism...

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Veröffentlicht in:	Journal of separation science 2024-10, Vol.47 (19), p.e202400486-n/a
Hauptverfasser:	Li, Haixia, Li, KaiLin, Cheng, Wenhui, Liu, Mingjuan, Wen, Linwen, Zhang, Zexu, Zhang, Wendan, Su, Jin, Cai, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - metabolism Biological activity characterization \| metabolites \| molecular docking \| sinomenine \| UHPLC‐Q‐Exactive Orbitrap mass spectrometry Chromatography Chromatography, High Pressure Liquid - methods Dehydrogenation demethylation dihydroxylation drugs feces Hydroxylation In vivo methods and tests Liquid chromatography Male Mass Spectrometry Metabolism Metabolites Molecular docking Molecular Docking Simulation Molecular Structure Morphinans - chemistry Morphinans - metabolism Quadrupoles Rats Rats, Sprague-Dawley rheumatoid arthritis Scientific imaging separation sinomenine Sinomenium - chemistry Sinomenium acutum Sulfation therapeutics ultra-performance liquid chromatography urine
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