PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity

Mitochondrion-related cardiotoxicity due to cardiotoxin stimuli is closely linked to abnormal activities of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), followed by co-inactivation of nuclear respiratory factor-1(NRF1). Pharmacological interventions targeting mitoch...

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Veröffentlicht in:	Food and chemical toxicology 2023-01, Vol.171, p.113513, Article 113513
Hauptverfasser:	Qi, Xiao-Ming, Qiao, Yuan-Biao, Zhang, Yuan-Lin, Wang, Ai-Cheng, Ren, Jin-Hong, Wei, Hui-Zhi, Li, Qing-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients aspartate transaminase biogenesis blood serum Calycosin cardiomyocytes Cardiotoxicity creatine kinase extracellular space Humans isozymes lactate dehydrogenase membrane potential mitochondria Mitochondrial biogenesis mitochondrial DNA mitochondrial membrane Nuclear respiratory factor-1(NRF1) Organelle Biogenesis Oxidative Phosphorylation peroxisome proliferator-activated receptor gamma Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) sirtuins toxicology Transcription Factors - metabolism Triptolide troponin I
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