Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico
Sepsis-induced acute lung injury (ALI) presents with significant morbidity and mortality in clinical settings. Tanreqing Injection (TRQI) has been clinically recommended for the treatment of ALI; however, the specific active chemical constituents remain unidentified. This study aimed to elucidate th...
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| creator | Tang, Bixi Xie, Like Wang, Yangyang Shi, Yulong Kan, Weijuan Feng, Bo Lin, Chenxuan Xu, Zhijian Zhu, Weiliang Li, Jia Zhang, Xuemei Tian, Xiaoting Zang, Yi |
| description | Sepsis-induced acute lung injury (ALI) presents with significant morbidity and mortality in clinical settings. Tanreqing Injection (TRQI) has been clinically recommended for the treatment of ALI; however, the specific active chemical constituents remain unidentified.
This study aimed to elucidate the potential pharmacologically active components and the underlying mechanisms of TRQI in the treatment of sepsis-induced ALI.
High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) techniques were employed to identify the effective chemical constituents of TRQI. Additionally, an in vitro study was conducted using Raw264.7 macrophage cells stimulated with lipopolysaccharide (LPS) to evaluate the inhibitory effects of TRQI. An acute lung injury model produced by LPS was intraperitoneal injection in mice to assess the ALI-inhibitory effect of TRQI. The lung's pathological characteristics were examined using hematoxylin and eosin staining. Enzyme-linked immunosorbent assay (ELISA) and QPCR were performed to confirm the pharmaceutical effect. Network pharmacology was employed for mechanistic exploration, incorporating GO, and PPI analyses of targets. Src inhibitor and JNK agonist used to investigate the dependence of associated signaling pathways.
Combining pharmacokinetic characteristics, lung first-pass effect and anti-inflammatory effects, the main components of TRQI for treating sepsis induced ALI were narrowed down to seven compounds: chlorogenic acid, scutellarin, wogonoside, oroxyloside, oroxylin A and baicalein. Network pharmacology indicated that Src/JNK signaling pathway, may be the main regulatory pathway for treatment of actue lung injury. Next by using Src inhibitor, Src inhibition partly diminished the protective effects of TRQI in LPS-injected mice. Pretreatment with JNK agonist anisomycin abolished the protective effects of lung injury in vivo.
TRQI is injected, the seven compounds could be presented in vivo, which can improve ALI by inhibiting Src-JNK signaling.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2024.118780 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153831201</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874124010791</els_id><sourcerecordid>3103445933</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-ce44605eba7ba4ccbbaf42c11620645e6389fa715de6f47fa095024275a4883b3</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS0EotPCA7BBXrIgg_9ie2BVVQUqVWIDa8txrhlHmXhqO6POM_DSOEphiVjdH33nLM5B6A0lW0qo_DBsBzhuGWFiS6lWmjxDmzpZo1rFn6MN4Uo3Wgl6gS5zHgghigryEl3wHZNEEblBv24fj2NMtsR0xgky2OT2OE647AGD9-BKOAF2ezgEZ0fc2Rwyjh4XOyV4CNNPHKZhoarGx4RLAluWt3VzATzOKzGn80d8N-FTOMX39VGXkiK2U78cOYzBxVfohbdjhtdP8wr9-Hz7_eZrc__ty93N9X3jmNSlcSCEJC10VnVWONd11gvmKJWMSNGC5HrnraJtD9IL5S3ZtTUiplortOYdv0LvVt9jig8z5GIOITsYRztBnLPhtOWaU0bof6CEC9HuOK8oXVGXYs4JvDmmcLDpbCgxS11mMLUus9Rl1rqq5u2T_dwdoP-r-NNPBT6tANQ8TgGSyS7A5KAPqYZu-hj-Yf8bDLemsQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3103445933</pqid></control><display><type>article</type><title>Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Tang, Bixi ; Xie, Like ; Wang, Yangyang ; Shi, Yulong ; Kan, Weijuan ; Feng, Bo ; Lin, Chenxuan ; Xu, Zhijian ; Zhu, Weiliang ; Li, Jia ; Zhang, Xuemei ; Tian, Xiaoting ; Zang, Yi</creator><creatorcontrib>Tang, Bixi ; Xie, Like ; Wang, Yangyang ; Shi, Yulong ; Kan, Weijuan ; Feng, Bo ; Lin, Chenxuan ; Xu, Zhijian ; Zhu, Weiliang ; Li, Jia ; Zhang, Xuemei ; Tian, Xiaoting ; Zang, Yi</creatorcontrib><description>Sepsis-induced acute lung injury (ALI) presents with significant morbidity and mortality in clinical settings. Tanreqing Injection (TRQI) has been clinically recommended for the treatment of ALI; however, the specific active chemical constituents remain unidentified.
This study aimed to elucidate the potential pharmacologically active components and the underlying mechanisms of TRQI in the treatment of sepsis-induced ALI.
High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) techniques were employed to identify the effective chemical constituents of TRQI. Additionally, an in vitro study was conducted using Raw264.7 macrophage cells stimulated with lipopolysaccharide (LPS) to evaluate the inhibitory effects of TRQI. An acute lung injury model produced by LPS was intraperitoneal injection in mice to assess the ALI-inhibitory effect of TRQI. The lung's pathological characteristics were examined using hematoxylin and eosin staining. Enzyme-linked immunosorbent assay (ELISA) and QPCR were performed to confirm the pharmaceutical effect. Network pharmacology was employed for mechanistic exploration, incorporating GO, and PPI analyses of targets. Src inhibitor and JNK agonist used to investigate the dependence of associated signaling pathways.
Combining pharmacokinetic characteristics, lung first-pass effect and anti-inflammatory effects, the main components of TRQI for treating sepsis induced ALI were narrowed down to seven compounds: chlorogenic acid, scutellarin, wogonoside, oroxyloside, oroxylin A and baicalein. Network pharmacology indicated that Src/JNK signaling pathway, may be the main regulatory pathway for treatment of actue lung injury. Next by using Src inhibitor, Src inhibition partly diminished the protective effects of TRQI in LPS-injected mice. Pretreatment with JNK agonist anisomycin abolished the protective effects of lung injury in vivo.
TRQI is injected, the seven compounds could be presented in vivo, which can improve ALI by inhibiting Src-JNK signaling.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>ISSN: 1872-7573</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2024.118780</identifier><identifier>PMID: 39260706</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Acute Lung Injury - drug therapy ; Acute Lung Injury - metabolism ; Acute respiratory distress syndrome ; agonists ; Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; chlorogenic acid ; Chromatography, High Pressure Liquid ; computer simulation ; Disease Models, Animal ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; enzyme-linked immunosorbent assay ; eosin ; intraperitoneal injection ; lipopolysaccharides ; Lipopolysaccharides - toxicity ; liquid chromatography ; Lung - drug effects ; Lung - metabolism ; Lung - pathology ; Lung first-pass effect ; lungs ; macrophages ; Male ; medicinal properties ; Mice ; Mice, Inbred C57BL ; mortality ; Network Pharmacology ; Pharmacokinetics ; RAW 264.7 Cells ; Sepsis - drug therapy ; Sepsis-associated acute lung injury ; Signal Transduction - drug effects ; src-Family Kinases - antagonists & inhibitors ; src-Family Kinases - metabolism ; Tandem Mass Spectrometry ; Tanreqing injection ; traditional medicine</subject><ispartof>Journal of ethnopharmacology, 2025-01, Vol.337 (Pt 1), p.118780, Article 118780</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-ce44605eba7ba4ccbbaf42c11620645e6389fa715de6f47fa095024275a4883b3</cites><orcidid>0000-0002-3063-8473</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874124010791$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39260706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Bixi</creatorcontrib><creatorcontrib>Xie, Like</creatorcontrib><creatorcontrib>Wang, Yangyang</creatorcontrib><creatorcontrib>Shi, Yulong</creatorcontrib><creatorcontrib>Kan, Weijuan</creatorcontrib><creatorcontrib>Feng, Bo</creatorcontrib><creatorcontrib>Lin, Chenxuan</creatorcontrib><creatorcontrib>Xu, Zhijian</creatorcontrib><creatorcontrib>Zhu, Weiliang</creatorcontrib><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Zhang, Xuemei</creatorcontrib><creatorcontrib>Tian, Xiaoting</creatorcontrib><creatorcontrib>Zang, Yi</creatorcontrib><title>Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Sepsis-induced acute lung injury (ALI) presents with significant morbidity and mortality in clinical settings. Tanreqing Injection (TRQI) has been clinically recommended for the treatment of ALI; however, the specific active chemical constituents remain unidentified.
This study aimed to elucidate the potential pharmacologically active components and the underlying mechanisms of TRQI in the treatment of sepsis-induced ALI.
High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) techniques were employed to identify the effective chemical constituents of TRQI. Additionally, an in vitro study was conducted using Raw264.7 macrophage cells stimulated with lipopolysaccharide (LPS) to evaluate the inhibitory effects of TRQI. An acute lung injury model produced by LPS was intraperitoneal injection in mice to assess the ALI-inhibitory effect of TRQI. The lung's pathological characteristics were examined using hematoxylin and eosin staining. Enzyme-linked immunosorbent assay (ELISA) and QPCR were performed to confirm the pharmaceutical effect. Network pharmacology was employed for mechanistic exploration, incorporating GO, and PPI analyses of targets. Src inhibitor and JNK agonist used to investigate the dependence of associated signaling pathways.
Combining pharmacokinetic characteristics, lung first-pass effect and anti-inflammatory effects, the main components of TRQI for treating sepsis induced ALI were narrowed down to seven compounds: chlorogenic acid, scutellarin, wogonoside, oroxyloside, oroxylin A and baicalein. Network pharmacology indicated that Src/JNK signaling pathway, may be the main regulatory pathway for treatment of actue lung injury. Next by using Src inhibitor, Src inhibition partly diminished the protective effects of TRQI in LPS-injected mice. Pretreatment with JNK agonist anisomycin abolished the protective effects of lung injury in vivo.
TRQI is injected, the seven compounds could be presented in vivo, which can improve ALI by inhibiting Src-JNK signaling.
[Display omitted]</description><subject>Acute Lung Injury - drug therapy</subject><subject>Acute Lung Injury - metabolism</subject><subject>Acute respiratory distress syndrome</subject><subject>agonists</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>chlorogenic acid</subject><subject>Chromatography, High Pressure Liquid</subject><subject>computer simulation</subject><subject>Disease Models, Animal</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>enzyme-linked immunosorbent assay</subject><subject>eosin</subject><subject>intraperitoneal injection</subject><subject>lipopolysaccharides</subject><subject>Lipopolysaccharides - toxicity</subject><subject>liquid chromatography</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung first-pass effect</subject><subject>lungs</subject><subject>macrophages</subject><subject>Male</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>mortality</subject><subject>Network Pharmacology</subject><subject>Pharmacokinetics</subject><subject>RAW 264.7 Cells</subject><subject>Sepsis - drug therapy</subject><subject>Sepsis-associated acute lung injury</subject><subject>Signal Transduction - drug effects</subject><subject>src-Family Kinases - antagonists & inhibitors</subject><subject>src-Family Kinases - metabolism</subject><subject>Tandem Mass Spectrometry</subject><subject>Tanreqing injection</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EotPCA7BBXrIgg_9ie2BVVQUqVWIDa8txrhlHmXhqO6POM_DSOEphiVjdH33nLM5B6A0lW0qo_DBsBzhuGWFiS6lWmjxDmzpZo1rFn6MN4Uo3Wgl6gS5zHgghigryEl3wHZNEEblBv24fj2NMtsR0xgky2OT2OE647AGD9-BKOAF2ezgEZ0fc2Rwyjh4XOyV4CNNPHKZhoarGx4RLAluWt3VzATzOKzGn80d8N-FTOMX39VGXkiK2U78cOYzBxVfohbdjhtdP8wr9-Hz7_eZrc__ty93N9X3jmNSlcSCEJC10VnVWONd11gvmKJWMSNGC5HrnraJtD9IL5S3ZtTUiplortOYdv0LvVt9jig8z5GIOITsYRztBnLPhtOWaU0bof6CEC9HuOK8oXVGXYs4JvDmmcLDpbCgxS11mMLUus9Rl1rqq5u2T_dwdoP-r-NNPBT6tANQ8TgGSyS7A5KAPqYZu-hj-Yf8bDLemsQ</recordid><startdate>20250130</startdate><enddate>20250130</enddate><creator>Tang, Bixi</creator><creator>Xie, Like</creator><creator>Wang, Yangyang</creator><creator>Shi, Yulong</creator><creator>Kan, Weijuan</creator><creator>Feng, Bo</creator><creator>Lin, Chenxuan</creator><creator>Xu, Zhijian</creator><creator>Zhu, Weiliang</creator><creator>Li, Jia</creator><creator>Zhang, Xuemei</creator><creator>Tian, Xiaoting</creator><creator>Zang, Yi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-3063-8473</orcidid></search><sort><creationdate>20250130</creationdate><title>Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico</title><author>Tang, Bixi ; Xie, Like ; Wang, Yangyang ; Shi, Yulong ; Kan, Weijuan ; Feng, Bo ; Lin, Chenxuan ; Xu, Zhijian ; Zhu, Weiliang ; Li, Jia ; Zhang, Xuemei ; Tian, Xiaoting ; Zang, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-ce44605eba7ba4ccbbaf42c11620645e6389fa715de6f47fa095024275a4883b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Acute Lung Injury - drug therapy</topic><topic>Acute Lung Injury - metabolism</topic><topic>Acute respiratory distress syndrome</topic><topic>agonists</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>chlorogenic acid</topic><topic>Chromatography, High Pressure Liquid</topic><topic>computer simulation</topic><topic>Disease Models, Animal</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>enzyme-linked immunosorbent assay</topic><topic>eosin</topic><topic>intraperitoneal injection</topic><topic>lipopolysaccharides</topic><topic>Lipopolysaccharides - toxicity</topic><topic>liquid chromatography</topic><topic>Lung - drug effects</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung first-pass effect</topic><topic>lungs</topic><topic>macrophages</topic><topic>Male</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>mortality</topic><topic>Network Pharmacology</topic><topic>Pharmacokinetics</topic><topic>RAW 264.7 Cells</topic><topic>Sepsis - drug therapy</topic><topic>Sepsis-associated acute lung injury</topic><topic>Signal Transduction - drug effects</topic><topic>src-Family Kinases - antagonists & inhibitors</topic><topic>src-Family Kinases - metabolism</topic><topic>Tandem Mass Spectrometry</topic><topic>Tanreqing injection</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Bixi</creatorcontrib><creatorcontrib>Xie, Like</creatorcontrib><creatorcontrib>Wang, Yangyang</creatorcontrib><creatorcontrib>Shi, Yulong</creatorcontrib><creatorcontrib>Kan, Weijuan</creatorcontrib><creatorcontrib>Feng, Bo</creatorcontrib><creatorcontrib>Lin, Chenxuan</creatorcontrib><creatorcontrib>Xu, Zhijian</creatorcontrib><creatorcontrib>Zhu, Weiliang</creatorcontrib><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Zhang, Xuemei</creatorcontrib><creatorcontrib>Tian, Xiaoting</creatorcontrib><creatorcontrib>Zang, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Bixi</au><au>Xie, Like</au><au>Wang, Yangyang</au><au>Shi, Yulong</au><au>Kan, Weijuan</au><au>Feng, Bo</au><au>Lin, Chenxuan</au><au>Xu, Zhijian</au><au>Zhu, Weiliang</au><au>Li, Jia</au><au>Zhang, Xuemei</au><au>Tian, Xiaoting</au><au>Zang, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2025-01-30</date><risdate>2025</risdate><volume>337</volume><issue>Pt 1</issue><spage>118780</spage><pages>118780-</pages><artnum>118780</artnum><issn>0378-8741</issn><issn>1872-7573</issn><eissn>1872-7573</eissn><abstract>Sepsis-induced acute lung injury (ALI) presents with significant morbidity and mortality in clinical settings. Tanreqing Injection (TRQI) has been clinically recommended for the treatment of ALI; however, the specific active chemical constituents remain unidentified.
This study aimed to elucidate the potential pharmacologically active components and the underlying mechanisms of TRQI in the treatment of sepsis-induced ALI.
High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) techniques were employed to identify the effective chemical constituents of TRQI. Additionally, an in vitro study was conducted using Raw264.7 macrophage cells stimulated with lipopolysaccharide (LPS) to evaluate the inhibitory effects of TRQI. An acute lung injury model produced by LPS was intraperitoneal injection in mice to assess the ALI-inhibitory effect of TRQI. The lung's pathological characteristics were examined using hematoxylin and eosin staining. Enzyme-linked immunosorbent assay (ELISA) and QPCR were performed to confirm the pharmaceutical effect. Network pharmacology was employed for mechanistic exploration, incorporating GO, and PPI analyses of targets. Src inhibitor and JNK agonist used to investigate the dependence of associated signaling pathways.
Combining pharmacokinetic characteristics, lung first-pass effect and anti-inflammatory effects, the main components of TRQI for treating sepsis induced ALI were narrowed down to seven compounds: chlorogenic acid, scutellarin, wogonoside, oroxyloside, oroxylin A and baicalein. Network pharmacology indicated that Src/JNK signaling pathway, may be the main regulatory pathway for treatment of actue lung injury. Next by using Src inhibitor, Src inhibition partly diminished the protective effects of TRQI in LPS-injected mice. Pretreatment with JNK agonist anisomycin abolished the protective effects of lung injury in vivo.
TRQI is injected, the seven compounds could be presented in vivo, which can improve ALI by inhibiting Src-JNK signaling.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>39260706</pmid><doi>10.1016/j.jep.2024.118780</doi><orcidid>https://orcid.org/0000-0002-3063-8473</orcidid></addata></record> |
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| subjects | Acute Lung Injury - drug therapy Acute Lung Injury - metabolism Acute respiratory distress syndrome agonists Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use chlorogenic acid Chromatography, High Pressure Liquid computer simulation Disease Models, Animal Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use enzyme-linked immunosorbent assay eosin intraperitoneal injection lipopolysaccharides Lipopolysaccharides - toxicity liquid chromatography Lung - drug effects Lung - metabolism Lung - pathology Lung first-pass effect lungs macrophages Male medicinal properties Mice Mice, Inbred C57BL mortality Network Pharmacology Pharmacokinetics RAW 264.7 Cells Sepsis - drug therapy Sepsis-associated acute lung injury Signal Transduction - drug effects src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism Tandem Mass Spectrometry Tanreqing injection traditional medicine |
| title | Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico |
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