Macrophage corpses for immunoregulation and targeted drug delivery in treatment of collagen-induced arthritis mice

The role of pro-inflammatory macrophages (M1) in rheumatoid arthritis (RA) is significant, as they produce excessive cytokines. Targeting efferocytosis is a potential manner to repolarize M1 macrophages into pro-resolving M2 phenotype, which restores immune homeostasis by releasing anti-inflammatory...

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Veröffentlicht in:	Biomaterials 2025-03, Vol.314, p.122867, Article 122867
Hauptverfasser:	Li, Yuhuan, Lv, Jiayin, Liu, Shuchen, Wang, Zhuoran, Gao, Yu, Fan, Zheyuan, Huang, Lei, Cui, Jing, Zhang, Boya, Liu, Xinchen, Zhang, Zhuo, Liu, Te, Li, Daowei, Yang, Modi
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated protein kinase Animals Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology biocompatible materials cartilage cytokines drug carriers Drug Delivery Systems drugs Efferocytosis homeostasis Immunometabolism immunomodulation intravenous injection Liquid nitrogen-treated cells liquids Macrophage repolarization macrophages Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL Naphthoquinones - pharmacology Naphthoquinones - therapeutic use oxidative phosphorylation phenotype Rheumatoid arthritis shikonin
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