Refinement and optimisation of Neisseria gonorrhoeae NHBA and MetQ vaccine candidates

Neisseria gonorrhoeae has a significant impact on reproductive health with an estimated 82 million new cases of infection per year worldwide. Due to the ongoing emergence of multidrug-resistant N. gonorrhoeae strains, the high number of asymptomatic cases, and the risk of disease sequelae, the devel...

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Veröffentlicht in:	Vaccine 2024-12, Vol.42 (26), p.126416, Article 126416
Hauptverfasser:	Taha, Eskandari, Sharareh, Slesarenko, Valentin A., Haselhorst, Thomas, Semchenko, Evgeny A., Seib, Kate L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Aluminum hydroxide Amino acids Animals antibacterial properties Antibodies Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Asymptomatic Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Bactericidal activity Blood Bactericidal Activity blood serum Cervix Complications complications (disease) Epithelial cells Epithelium Female Fragments Functional activity Gonococcus Gonorrhea Gonorrhea - immunology Gonorrhea - prevention & control Health risks Heparin Humans Immune response Immunogenicity Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Infection blocking Infections Infertility Methionine Methionine-binding protein (MetQ) Mice Mice, Inbred BALB C Multidrug resistance multiple drug resistance Neisseria gonorrhoeae Neisseria gonorrhoeae - genetics Neisseria gonorrhoeae - immunology Neisseria heparin binding antigen (NHBA) Opsonophagocytic activity Phagocytosis Proteins Public health Reproductive health risk Risk assessment Serum bactericidal activity Vaccine Vaccine development Vaccines Variance analysis
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