Modeling the profibrotic microenvironment in vitro: Model validation

Establishing the molecular and cellular mechanisms of fibrosis requires the development of validated and reproducible models. The complexity of in vivo models challenges the monitoring of an individual cell fate, in some cases making it impossible. However, the set of factors affecting cells in vitr...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-11, Vol.733, p.150574, Article 150574
Hauptverfasser:	Grigorieva, Olga, Basalova, Nataliya, Dyachkova, Uliana, Novoseletskaya, Ekaterina, Vigovskii, Maksim, Arbatskiy, Mikhail, Kulebyakina, Maria, Efimenko, Anastasia
Format:	Artikel
Sprache:	eng
Schlagworte:	actin adipose tissue ascorbic acid bioinformatics Cell Differentiation Cells, Cultured Cellular Microenvironment collagen extracellular matrix Extracellular Matrix - metabolism fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Fibrosis genes hepatocyte growth factor Humans Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism microRNA MicroRNAs - genetics MicroRNAs - metabolism model validation Models, Biological muscles Myofibroblasts - cytology Myofibroblasts - metabolism Myofibroblasts - pathology Osteonectin - genetics Osteonectin - metabolism secretion therapeutics Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology
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