Gamabufotalin loaded micro-nanocomposites for multimodal therapy of metastatic TNBC by efficiently inducing ICD

Gamabufotalin (CS-6), a main active compound derived from Chinese medicine Chansu, exhibits a robust inhibitory effect on programmed death-ligand 1 (PD-L1) in triple-negative breast cancer (TNBC) cells. Despite its potential for tumor therapy, the medical application of CS-6 is constrained by its hy...

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Veröffentlicht in:	Biomaterials 2025-03, Vol.314, p.122851, Article 122851
Hauptverfasser:	Fan, Jialong, Qin, Yan, Qiu, Wensheng, Liang, Jiahao, Xiao, Chang, Xie, Qian, Tong, Chunyi, Yuan, Liqin, Long, Ying, Liu, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients Animals apoptosis Apoptosis - drug effects biocompatible materials breast neoplasms Cell Line, Tumor chemotaxis Combined Modality Therapy drug therapy drugs Female Ferrocyanides - chemistry Ferrocyanides - pharmacology Gamabufotalin Humans hydrophobicity ICD Immunogenic Cell Death - drug effects immunosuppression macrophages metastasis Mice Mice, Inbred BALB C Nanocomposites - chemistry nanomedicine nanoparticles necroptosis neoplasm cells Neoplasm Metastasis neoplasm progression Oriental traditional medicine PD-L1 Photothermal Therapy - methods photothermotherapy PTT S.lux Salmonella Typhimurium TNBC Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - pathology Triple Negative Breast Neoplasms - therapy Xanthones - chemistry Xanthones - pharmacology
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