ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

ATG9A and ATG2A are essential core members of the autophagy machinery. ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer, whereas ATG2A facilitates lipid flow between tethered membranes. Although both have been functionally linked during the formation of autop...

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Veröffentlicht in:	Molecular cell 2022-11, Vol.82 (22), p.4324-4339.e8
Hauptverfasser:	van Vliet, Alexander R., Chiduza, George N., Maslen, Sarah L., Pye, Valerie E., Joshi, Dhira, De Tito, Stefano, Jefferies, Harold B.J., Christodoulou, Evangelos, Roustan, Chloë, Punch, Emma, Hervás, Javier H., O’Reilly, Nicola, Skehel, J. Mark, Cherepanov, Peter, Tooze, Sharon A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AlphaFold autophagosome Autophagosomes Autophagy Biological Assay crosslinking cryo-electron microscopy Cryoelectron Microscopy integrative structure prediction lipid scramblase lipid transfer Lipids mass spectrometry molecular models peptides
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