Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair
Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chit...
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| Veröffentlicht in: | Carbohydrate polymers 2023-04, Vol.305, p.120545-120545, Article 120545 |
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| container_title | Carbohydrate polymers |
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| creator | Cao, Shujun Bi, Zhanjian Li, Qiujing Zhang, Shukun Singh, Moganavelli Chen, Jingdi |
| description | Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through the reduction of Ag+ with tannic acid (TA) as a reducing agent. The CS/CA/Ag cryogel has good mechanical properties and interconnected macroporous structures. The results of hemostasis tests show that CS/CA/Ag cryogel can absorb a large amount of blood and promote blood cell adhesion compared with commercial gelatin sponges and gauze. Meanwhile, CS/CA/Ag cryogel has a good antibacterial ability against S. aureus and E. coli. Furthermore, CS/CA/Ag cryogel significantly promotes wound healing in the full-thickness wound model infected with S. aureus. In conclusion, the cryogel prepared by the simple method has great advantages in rapid hemostasis and promoting wound healing. |
| doi_str_mv | 10.1016/j.carbpol.2023.120545 |
| format | Article |
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Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through the reduction of Ag+ with tannic acid (TA) as a reducing agent. The CS/CA/Ag cryogel has good mechanical properties and interconnected macroporous structures. The results of hemostasis tests show that CS/CA/Ag cryogel can absorb a large amount of blood and promote blood cell adhesion compared with commercial gelatin sponges and gauze. Meanwhile, CS/CA/Ag cryogel has a good antibacterial ability against S. aureus and E. coli. Furthermore, CS/CA/Ag cryogel significantly promotes wound healing in the full-thickness wound model infected with S. aureus. In conclusion, the cryogel prepared by the simple method has great advantages in rapid hemostasis and promoting wound healing.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2023.120545</identifier><identifier>PMID: 36737195</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Ag NPs ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; blood ; cell adhesion ; Chitosan ; Chitosan - chemistry ; Chitosan - pharmacology ; Citric acid ; cryogels ; Cryogels - chemistry ; Escherichia coli ; gelatin ; Hemostasis ; Humans ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - therapeutic use ; nanosilver ; porous media ; Shape memory cryogel ; Silver - chemistry ; Silver - pharmacology ; Soft Tissue Injuries ; Staphylococcus aureus ; tannins ; Wound Healing</subject><ispartof>Carbohydrate polymers, 2023-04, Vol.305, p.120545-120545, Article 120545</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-d778c14033779fcdbc9d055ee6971b0085447ba395179420cde19df444a6d0bc3</citedby><cites>FETCH-LOGICAL-c398t-d778c14033779fcdbc9d055ee6971b0085447ba395179420cde19df444a6d0bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0144861723000097$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36737195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Shujun</creatorcontrib><creatorcontrib>Bi, Zhanjian</creatorcontrib><creatorcontrib>Li, Qiujing</creatorcontrib><creatorcontrib>Zhang, Shukun</creatorcontrib><creatorcontrib>Singh, Moganavelli</creatorcontrib><creatorcontrib>Chen, Jingdi</creatorcontrib><title>Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through the reduction of Ag+ with tannic acid (TA) as a reducing agent. The CS/CA/Ag cryogel has good mechanical properties and interconnected macroporous structures. The results of hemostasis tests show that CS/CA/Ag cryogel can absorb a large amount of blood and promote blood cell adhesion compared with commercial gelatin sponges and gauze. Meanwhile, CS/CA/Ag cryogel has a good antibacterial ability against S. aureus and E. coli. Furthermore, CS/CA/Ag cryogel significantly promotes wound healing in the full-thickness wound model infected with S. aureus. In conclusion, the cryogel prepared by the simple method has great advantages in rapid hemostasis and promoting wound healing.</description><subject>Ag NPs</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>blood</subject><subject>cell adhesion</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - pharmacology</subject><subject>Citric acid</subject><subject>cryogels</subject><subject>Cryogels - chemistry</subject><subject>Escherichia coli</subject><subject>gelatin</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - therapeutic use</subject><subject>nanosilver</subject><subject>porous media</subject><subject>Shape memory cryogel</subject><subject>Silver - chemistry</subject><subject>Silver - pharmacology</subject><subject>Soft Tissue Injuries</subject><subject>Staphylococcus aureus</subject><subject>tannins</subject><subject>Wound Healing</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv2zAMhYWhw5Jl-wkrfOzFqWhJlnUaiqDtBhToYd1pB0GWmEWpbbmS3SD_vs6S9RoCBHn4Hh_AR8g3oEugUF5vl9bEug_NsqAFW0JBBRcfyBwqqXJgnF-QOQXO86oEOSOfU9rSqUqgn8iMlZJJUGJO_vzamB6zFtsQ95np3NSDr40dMHrTZHbjh5BMl9cmocts3Ie_2GQ7P2yyzSRKg0k-_ROmZ99luzBOa8Te-PiFfFybJuHX01yQ33e3T6sf-cPj_c_VzUNumaqG3ElZWeCUMSnV2rraKkeFQCyVhJrSSnAua8OUAKl4Qa1DUG7NOTelo7VlC3J1vNvH8DJiGnTrk8WmMR2GMWkGglWgyhLOooWUDEAodkDFEbUxpBRxrfvoWxP3Gqg-RKC3-hSBPkSgjxFMusuTxVi36N5V_38-Ad-PAE4_efUYdbIeO4vOR7SDdsGfsXgDIFaaFA</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Cao, Shujun</creator><creator>Bi, Zhanjian</creator><creator>Li, Qiujing</creator><creator>Zhang, Shukun</creator><creator>Singh, Moganavelli</creator><creator>Chen, Jingdi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20230401</creationdate><title>Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair</title><author>Cao, Shujun ; Bi, Zhanjian ; Li, Qiujing ; Zhang, Shukun ; Singh, Moganavelli ; Chen, Jingdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-d778c14033779fcdbc9d055ee6971b0085447ba395179420cde19df444a6d0bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ag NPs</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>blood</topic><topic>cell adhesion</topic><topic>Chitosan</topic><topic>Chitosan - chemistry</topic><topic>Chitosan - pharmacology</topic><topic>Citric acid</topic><topic>cryogels</topic><topic>Cryogels - chemistry</topic><topic>Escherichia coli</topic><topic>gelatin</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - therapeutic use</topic><topic>nanosilver</topic><topic>porous media</topic><topic>Shape memory cryogel</topic><topic>Silver - chemistry</topic><topic>Silver - pharmacology</topic><topic>Soft Tissue Injuries</topic><topic>Staphylococcus aureus</topic><topic>tannins</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Shujun</creatorcontrib><creatorcontrib>Bi, Zhanjian</creatorcontrib><creatorcontrib>Li, Qiujing</creatorcontrib><creatorcontrib>Zhang, Shukun</creatorcontrib><creatorcontrib>Singh, Moganavelli</creatorcontrib><creatorcontrib>Chen, Jingdi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Shujun</au><au>Bi, Zhanjian</au><au>Li, Qiujing</au><au>Zhang, Shukun</au><au>Singh, Moganavelli</au><au>Chen, Jingdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>305</volume><spage>120545</spage><epage>120545</epage><pages>120545-120545</pages><artnum>120545</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through the reduction of Ag+ with tannic acid (TA) as a reducing agent. The CS/CA/Ag cryogel has good mechanical properties and interconnected macroporous structures. The results of hemostasis tests show that CS/CA/Ag cryogel can absorb a large amount of blood and promote blood cell adhesion compared with commercial gelatin sponges and gauze. Meanwhile, CS/CA/Ag cryogel has a good antibacterial ability against S. aureus and E. coli. Furthermore, CS/CA/Ag cryogel significantly promotes wound healing in the full-thickness wound model infected with S. aureus. In conclusion, the cryogel prepared by the simple method has great advantages in rapid hemostasis and promoting wound healing.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36737195</pmid><doi>10.1016/j.carbpol.2023.120545</doi><tpages>1</tpages></addata></record> |
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| subjects | Ag NPs Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology blood cell adhesion Chitosan Chitosan - chemistry Chitosan - pharmacology Citric acid cryogels Cryogels - chemistry Escherichia coli gelatin Hemostasis Humans Metal Nanoparticles - chemistry Metal Nanoparticles - therapeutic use nanosilver porous media Shape memory cryogel Silver - chemistry Silver - pharmacology Soft Tissue Injuries Staphylococcus aureus tannins Wound Healing |
| title | Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair |
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