Platform establishment of the Cre-loxP recombination system for genetic manipulation of the Lumpy skin disease virus

Lumpy skin disease virus (LSDV) is a rapidly emerging pathogen in Asia, including China. Genetic manipulation of the LSDV is essential for the elucidation of the pathogenic mechanism and biological function of the LSDV-encoded protein. In this study, we established a platform for the Cre-loxP recomb...

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Veröffentlicht in:	Veterinary microbiology 2024-07, Vol.294, p.110122-110122, Article 110122
Hauptverfasser:	Ren, Shanhui, Zhang, Yuzhe, Gao, Xiaolong, Wang, Xiangwei, Tong, Lina, Wang, Shasha, Sun, Yuefeng, Yin, Xiangping, Chen, Haotai
Format:	Artikel
Sprache:	eng
Schlagworte:	cell lines China Cre-loxP system excision genetic engineering homologous recombination Lumpy skin disease virus MDBK-Cre cell line pathogens Recombinant virus recombinases reporter genes vaccines viruses
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