Reverse genetics based H5N2 vaccine provides clinical protection against H5N1, H5N8 and H9N2 avian influenza infection in chickens

•rgH5N2 vaccine alone is protective against H5N1/H5N8 and reduced replication of H9N2 in chickens.•HA stalk is immunogenic in chicken.•HA stalk is not protective against H5N1 or H5N8 in chicken; It may need an further improvement in its designing.•HA stalk did not have any beneficial effect in combi...

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Veröffentlicht in:	Vaccine 2022-11, Vol.40 (48), p.6998-7008
Hauptverfasser:	Panickan, Sivasankar, Bhatia, Sandeep, Bhat, Sushant, Bhandari, Nisha, Pateriya, Atul Kumar, Kalaiyarasu, Semmannan, Sood, Richa, Tripathi, Meghna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annual reports Antibodies Antibodies, Viral Avian flu avian influenza Challenge infection Chickens Chromatography Combined vaccines Disease Eggs Epidemics Genetics H5N1 H5N8 HA stalk Hemagglutination Immunization Infections Influenza Influenza A virus Influenza A Virus, H5N1 Subtype Influenza A Virus, H5N2 Subtype Influenza A Virus, H5N8 Subtype Influenza A Virus, H9N2 Subtype Influenza in Birds Influenza Vaccines Mice Pathogens Poultry Proteins Reverse Genetics rgH5N2 vaccine Specific pathogen free specific pathogen-free animals Vaccines Viruses
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