Calmodulin-Targeting Molecules from Ageratina grandifolia

Four new natural chemical entities, including 2-hydroxy-α-truxillic acid ( ), (3 ,4 )-2,2-dimethyl-3-hydroxy-4-(1-angeloyloxy)-6-acetyl-7-methoxychromane ( ), -tricosanoyltyramine ( ), and grandifolamide ( ), were isolated along with 11 known compounds ( , - ) from the aerial parts of . The chemical...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2023-11, Vol.86 (11), p.2562-2570
Hauptverfasser:	Gutiérrez-González, José A, Pérez-Vásquez, Araceli, González-Andrade, Martín, Galano, Annia, Villaseñor, José L, Mata, Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageratina Ageratina - chemistry ambient temperature calmodulin Calmodulin - chemistry Calmodulin - metabolism Calmodulin - pharmacology chlorpromazine Chromans - chemistry Chromans - isolation & purification Chromans - pharmacology derivatization Magnetic Resonance Spectroscopy molecular dynamics Molecular Dynamics Simulation Molecular Structure statistical analysis therapeutics
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