Ionotropic receptors mediate olfactory learning and memory in Drosophila
Phenylacetaldehyde (PAH), an aromatic compound, is present in a diverse range of fruits including overripe bananas and prickly pear cactus, the two major host fruits for Drosophila melanogaster. PAH acts as a potent ligand for the ionotropic receptor 84a (IR84a) in the adult fruit fly and it is dete...
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| creator | Ali, Md Zeeshan Anushree Ahsan, Aarif Ola, Mohammad Shamsul Haque, Rizwanul Ahsan, Jawaid |
| description | Phenylacetaldehyde (PAH), an aromatic compound, is present in a diverse range of fruits including overripe bananas and prickly pear cactus, the two major host fruits for Drosophila melanogaster. PAH acts as a potent ligand for the ionotropic receptor 84a (IR84a) in the adult fruit fly and it is detected by the IR84a/IR8a heterotetrameric complex. Its role in the male courtship behavior through IR84a as an environmental aphrodisiac is of additional importance. In D. melanogaster, two distinct kinds of olfactory receptors, that is, odorant receptors (ORs) and ionotropic receptors (IRs), perceive the odorant stimuli. They display unique structural, molecular, and functional characteristics in addition to having different evolutionary origins. Traditionally, olfactory cues detected by the ORs such as ethyl acetate, 1‐butanol, isoamyl acetate, 1‐octanol, 4‐methylcyclohexanol, etc. classified as aliphatic esters and alcohols have been employed in olfactory classical conditioning using fruit flies. This underlines the participation of OR‐activated olfactory pathways in learning and memory formation. Our study elucidates that likewise ethyl acetate (EA) (an OR‐responsive odorant), PAH (an IR‐responsive aromatic compound) too can form learning and memory when associated with an appetitive gustatory reinforcer. The association of PAH with sucrose (PAH/SUC) led to learning and formation of the long‐term memory (LTM). Additionally, the Orco1, Ir84aMI00501, and Ir8a1 mutant flies were used to confirm the exclusive participation of the IR84a/IR8a complex in PAH/SUC olfactory associative conditioning. These results highlight the involvement of IRs via an IR‐activated pathway in facilitating robust olfactory behavior.
Phenylacetaldehyde (an IR84a‐responsive aromatic compound) forms LTM with sucrose. Orco1, Ir84aMI00501, and Ir8a1 confirm exclusivity of IR84a/IR8a in PAH/SUC conditioning. Results underline the involvement of IRs in facilitating a flexible behavior. |
| doi_str_mv | 10.1111/1744-7917.13308 |
| format | Article |
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Phenylacetaldehyde (an IR84a‐responsive aromatic compound) forms LTM with sucrose. Orco1, Ir84aMI00501, and Ir8a1 confirm exclusivity of IR84a/IR8a in PAH/SUC conditioning. Results underline the involvement of IRs in facilitating a flexible behavior.</description><identifier>ISSN: 1672-9609</identifier><identifier>ISSN: 1744-7917</identifier><identifier>EISSN: 1744-7917</identifier><identifier>DOI: 10.1111/1744-7917.13308</identifier><identifier>PMID: 38114448</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>1-Octanol ; Acetic acid ; adults ; Alcohols ; Animals ; aphrodisiacs ; appetitive conditioning ; Aromatic compounds ; Bananas ; Butanol ; Classical conditioning ; Conditioning, Classical ; Courtship ; Drosophila melanogaster ; Drosophila melanogaster - physiology ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Esters ; Ethyl acetate ; Female ; Fruit flies ; Fruits ; Insects ; Ion channels (ligand-gated) ; ionotropic receptors ; Isoamyl acetate ; Learning ; learning and memory ; ligands ; Long term memory ; Male ; males ; Memory ; mutants ; Octanol ; odor compounds ; Odorant receptors ; Odorants ; Olfactory discrimination learning ; Olfactory pathways ; Olfactory stimuli ; Opuntia ; Phenylacetaldehyde ; Receptors ; Receptors, Ionotropic Glutamate - genetics ; Receptors, Ionotropic Glutamate - metabolism ; Receptors, Odorant - genetics ; Receptors, Odorant - metabolism ; Smell ; Structure-function relationships ; Sucrose ; taste</subject><ispartof>Insect science, 2024-08, Vol.31 (4), p.1249-1269</ispartof><rights>2023 Institute of Zoology, Chinese Academy of Sciences.</rights><rights>2024 Institute of Zoology, Chinese Academy of Sciences.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3588-d36d40f7a4b34569145c07b0e7f4403b5f46ff2eeb44a8783c70c431a01e3fd43</cites><orcidid>0000-0002-2977-9922</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1744-7917.13308$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1744-7917.13308$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38114448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, Md Zeeshan</creatorcontrib><creatorcontrib>Anushree</creatorcontrib><creatorcontrib>Ahsan, Aarif</creatorcontrib><creatorcontrib>Ola, Mohammad Shamsul</creatorcontrib><creatorcontrib>Haque, Rizwanul</creatorcontrib><creatorcontrib>Ahsan, Jawaid</creatorcontrib><title>Ionotropic receptors mediate olfactory learning and memory in Drosophila</title><title>Insect science</title><addtitle>Insect Sci</addtitle><description>Phenylacetaldehyde (PAH), an aromatic compound, is present in a diverse range of fruits including overripe bananas and prickly pear cactus, the two major host fruits for Drosophila melanogaster. PAH acts as a potent ligand for the ionotropic receptor 84a (IR84a) in the adult fruit fly and it is detected by the IR84a/IR8a heterotetrameric complex. Its role in the male courtship behavior through IR84a as an environmental aphrodisiac is of additional importance. In D. melanogaster, two distinct kinds of olfactory receptors, that is, odorant receptors (ORs) and ionotropic receptors (IRs), perceive the odorant stimuli. They display unique structural, molecular, and functional characteristics in addition to having different evolutionary origins. Traditionally, olfactory cues detected by the ORs such as ethyl acetate, 1‐butanol, isoamyl acetate, 1‐octanol, 4‐methylcyclohexanol, etc. classified as aliphatic esters and alcohols have been employed in olfactory classical conditioning using fruit flies. This underlines the participation of OR‐activated olfactory pathways in learning and memory formation. Our study elucidates that likewise ethyl acetate (EA) (an OR‐responsive odorant), PAH (an IR‐responsive aromatic compound) too can form learning and memory when associated with an appetitive gustatory reinforcer. The association of PAH with sucrose (PAH/SUC) led to learning and formation of the long‐term memory (LTM). Additionally, the Orco1, Ir84aMI00501, and Ir8a1 mutant flies were used to confirm the exclusive participation of the IR84a/IR8a complex in PAH/SUC olfactory associative conditioning. These results highlight the involvement of IRs via an IR‐activated pathway in facilitating robust olfactory behavior.
Phenylacetaldehyde (an IR84a‐responsive aromatic compound) forms LTM with sucrose. Orco1, Ir84aMI00501, and Ir8a1 confirm exclusivity of IR84a/IR8a in PAH/SUC conditioning. Results underline the involvement of IRs in facilitating a flexible behavior.</description><subject>1-Octanol</subject><subject>Acetic acid</subject><subject>adults</subject><subject>Alcohols</subject><subject>Animals</subject><subject>aphrodisiacs</subject><subject>appetitive conditioning</subject><subject>Aromatic compounds</subject><subject>Bananas</subject><subject>Butanol</subject><subject>Classical conditioning</subject><subject>Conditioning, Classical</subject><subject>Courtship</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Esters</subject><subject>Ethyl acetate</subject><subject>Female</subject><subject>Fruit flies</subject><subject>Fruits</subject><subject>Insects</subject><subject>Ion channels (ligand-gated)</subject><subject>ionotropic receptors</subject><subject>Isoamyl acetate</subject><subject>Learning</subject><subject>learning and memory</subject><subject>ligands</subject><subject>Long term memory</subject><subject>Male</subject><subject>males</subject><subject>Memory</subject><subject>mutants</subject><subject>Octanol</subject><subject>odor compounds</subject><subject>Odorant receptors</subject><subject>Odorants</subject><subject>Olfactory discrimination learning</subject><subject>Olfactory pathways</subject><subject>Olfactory stimuli</subject><subject>Opuntia</subject><subject>Phenylacetaldehyde</subject><subject>Receptors</subject><subject>Receptors, Ionotropic Glutamate - genetics</subject><subject>Receptors, Ionotropic Glutamate - metabolism</subject><subject>Receptors, Odorant - genetics</subject><subject>Receptors, Odorant - metabolism</subject><subject>Smell</subject><subject>Structure-function relationships</subject><subject>Sucrose</subject><subject>taste</subject><issn>1672-9609</issn><issn>1744-7917</issn><issn>1744-7917</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtPwzAUhS0EgvKY2VAkFpa0du5NHI-ovCpVMACz5Tg2pErjYDdC_fe4FBhY6sXWuZ-PdM8h5JzRMYtnwjhiygXjYwZAyz0y-lP247vgWSoKKo7IcQgLSkFkIjskR1AyhojliDzMXOdW3vWNTrzRpl85H5KlqRu1MolrrdJRWSetUb5rurdEdXUcLzda0yU33gXXvzetOiUHVrXBnP3cJ-T17vZl-pDOn-5n0-t5qiEvy7SGokZqucIKMC8Ew1xTXlHDLSKFKrdYWJsZUyGqkpegOdUITFFmwNYIJ-Rq69t79zGYsJLLJmjTtqozbggSWA4l5TnnO9FMUGR5gQVE9PIfunCD7-IiEqjIGIiYZaQmW0rHtYM3Vva-WSq_lozKTR9yk77cpC-_-4g_Ln58hyqG-sf_FhCBfAt8Nq1Z7_KTs8fnrfEXy1yTDg</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Ali, Md Zeeshan</creator><creator>Anushree</creator><creator>Ahsan, Aarif</creator><creator>Ola, Mohammad Shamsul</creator><creator>Haque, Rizwanul</creator><creator>Ahsan, Jawaid</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-2977-9922</orcidid></search><sort><creationdate>202408</creationdate><title>Ionotropic receptors mediate olfactory learning and memory in Drosophila</title><author>Ali, Md Zeeshan ; Anushree ; Ahsan, Aarif ; Ola, Mohammad Shamsul ; Haque, Rizwanul ; Ahsan, Jawaid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3588-d36d40f7a4b34569145c07b0e7f4403b5f46ff2eeb44a8783c70c431a01e3fd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>1-Octanol</topic><topic>Acetic acid</topic><topic>adults</topic><topic>Alcohols</topic><topic>Animals</topic><topic>aphrodisiacs</topic><topic>appetitive conditioning</topic><topic>Aromatic compounds</topic><topic>Bananas</topic><topic>Butanol</topic><topic>Classical conditioning</topic><topic>Conditioning, Classical</topic><topic>Courtship</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Esters</topic><topic>Ethyl acetate</topic><topic>Female</topic><topic>Fruit flies</topic><topic>Fruits</topic><topic>Insects</topic><topic>Ion channels (ligand-gated)</topic><topic>ionotropic receptors</topic><topic>Isoamyl acetate</topic><topic>Learning</topic><topic>learning and memory</topic><topic>ligands</topic><topic>Long term memory</topic><topic>Male</topic><topic>males</topic><topic>Memory</topic><topic>mutants</topic><topic>Octanol</topic><topic>odor compounds</topic><topic>Odorant receptors</topic><topic>Odorants</topic><topic>Olfactory discrimination learning</topic><topic>Olfactory pathways</topic><topic>Olfactory stimuli</topic><topic>Opuntia</topic><topic>Phenylacetaldehyde</topic><topic>Receptors</topic><topic>Receptors, Ionotropic Glutamate - genetics</topic><topic>Receptors, Ionotropic Glutamate - metabolism</topic><topic>Receptors, Odorant - genetics</topic><topic>Receptors, Odorant - metabolism</topic><topic>Smell</topic><topic>Structure-function relationships</topic><topic>Sucrose</topic><topic>taste</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ali, Md Zeeshan</creatorcontrib><creatorcontrib>Anushree</creatorcontrib><creatorcontrib>Ahsan, Aarif</creatorcontrib><creatorcontrib>Ola, Mohammad Shamsul</creatorcontrib><creatorcontrib>Haque, Rizwanul</creatorcontrib><creatorcontrib>Ahsan, Jawaid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Insect science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, Md Zeeshan</au><au>Anushree</au><au>Ahsan, Aarif</au><au>Ola, Mohammad Shamsul</au><au>Haque, Rizwanul</au><au>Ahsan, Jawaid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ionotropic receptors mediate olfactory learning and memory in Drosophila</atitle><jtitle>Insect science</jtitle><addtitle>Insect Sci</addtitle><date>2024-08</date><risdate>2024</risdate><volume>31</volume><issue>4</issue><spage>1249</spage><epage>1269</epage><pages>1249-1269</pages><issn>1672-9609</issn><issn>1744-7917</issn><eissn>1744-7917</eissn><abstract>Phenylacetaldehyde (PAH), an aromatic compound, is present in a diverse range of fruits including overripe bananas and prickly pear cactus, the two major host fruits for Drosophila melanogaster. PAH acts as a potent ligand for the ionotropic receptor 84a (IR84a) in the adult fruit fly and it is detected by the IR84a/IR8a heterotetrameric complex. Its role in the male courtship behavior through IR84a as an environmental aphrodisiac is of additional importance. In D. melanogaster, two distinct kinds of olfactory receptors, that is, odorant receptors (ORs) and ionotropic receptors (IRs), perceive the odorant stimuli. They display unique structural, molecular, and functional characteristics in addition to having different evolutionary origins. Traditionally, olfactory cues detected by the ORs such as ethyl acetate, 1‐butanol, isoamyl acetate, 1‐octanol, 4‐methylcyclohexanol, etc. classified as aliphatic esters and alcohols have been employed in olfactory classical conditioning using fruit flies. This underlines the participation of OR‐activated olfactory pathways in learning and memory formation. Our study elucidates that likewise ethyl acetate (EA) (an OR‐responsive odorant), PAH (an IR‐responsive aromatic compound) too can form learning and memory when associated with an appetitive gustatory reinforcer. The association of PAH with sucrose (PAH/SUC) led to learning and formation of the long‐term memory (LTM). Additionally, the Orco1, Ir84aMI00501, and Ir8a1 mutant flies were used to confirm the exclusive participation of the IR84a/IR8a complex in PAH/SUC olfactory associative conditioning. These results highlight the involvement of IRs via an IR‐activated pathway in facilitating robust olfactory behavior.
Phenylacetaldehyde (an IR84a‐responsive aromatic compound) forms LTM with sucrose. Orco1, Ir84aMI00501, and Ir8a1 confirm exclusivity of IR84a/IR8a in PAH/SUC conditioning. Results underline the involvement of IRs in facilitating a flexible behavior.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38114448</pmid><doi>10.1111/1744-7917.13308</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-2977-9922</orcidid></addata></record> |
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| subjects | 1-Octanol Acetic acid adults Alcohols Animals aphrodisiacs appetitive conditioning Aromatic compounds Bananas Butanol Classical conditioning Conditioning, Classical Courtship Drosophila melanogaster Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Esters Ethyl acetate Female Fruit flies Fruits Insects Ion channels (ligand-gated) ionotropic receptors Isoamyl acetate Learning learning and memory ligands Long term memory Male males Memory mutants Octanol odor compounds Odorant receptors Odorants Olfactory discrimination learning Olfactory pathways Olfactory stimuli Opuntia Phenylacetaldehyde Receptors Receptors, Ionotropic Glutamate - genetics Receptors, Ionotropic Glutamate - metabolism Receptors, Odorant - genetics Receptors, Odorant - metabolism Smell Structure-function relationships Sucrose taste |
| title | Ionotropic receptors mediate olfactory learning and memory in Drosophila |
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