Carryover analysis by liquid chromatography mass spectrometry in a multiproduct resin reuse context

The reuse of the same chromatography resin to purify multiple products is of high economic and ecologic interest in the pharmaceutical industry. An effective cleaning program to ensure no product carryover from one product to the subsequent is key to enable a multi-product use strategy. The methods...

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Veröffentlicht in:	Process biochemistry (1991) 2024-11, Vol.146, p.547-559
Hauptverfasser:	Helle, Stanislas, Santos da Silva, Francisco Vitor, McAvinue, Jodie, Coffey, Laura, Arthur, Aisling, Cawley, Jonathan, Brophy, Mark, O’Neill, Amie, Sheehy, Mary, Kelly, Ronan M., Ahern, Theresa, Osborne, Matthew D., Horgan, Conor P., Foley, Derek, Hayes, Ronan, Monaghan, Donal, O'Brien, Pamela, Mahon, James, Hudson, Sarah P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity chromatography biochemistry bioinformatics Biopharmaceutics capillary electrophoresis liquid chromatography Mass-spectrometry Multiproduct pharmaceutical industry Protein A Resin Resin reuse
Online-Zugang:	Volltext
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