Efficacy of Silkworm Pupae Extract on Muscle Strength and Mass in Middle-Aged and Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial
Objectives We investigated the efficacy and safety of silkworm pupae extract (SWP) consumption for 12 weeks on muscle mass and strength in middle-aged and older individuals with relatively low skeletal muscle mass who do regular low-intensity exercise. Design A randomized double-blinded placebo-cont...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2023-07, Vol.27 (7), p.578-585 |
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| creator | Choi, J. I. Kweon, H. Y. Lee, Y. L. Lee, J. H. Lee, Sang Yeoup |
| description | Objectives
We investigated the efficacy and safety of silkworm pupae extract (SWP) consumption for 12 weeks on muscle mass and strength in middle-aged and older individuals with relatively low skeletal muscle mass who do regular low-intensity exercise.
Design
A randomized double-blinded placebo-controlled trial.
Participants
The study was conducted with 54 participants with relatively low skeletal muscle mass (SMM) (64.4 ± 6.1 years; body mass index, 23.8 ± 2.4 kg/m
2
).
Intervention and Measurements
Participants were randomly assigned to one of two groups: 1000 mg of SWP/day plus regular exercise (SWP group, n=27) or placebo plus regular exercise (placebo group, n=27). All participants were required to engage in 30–60 minutes/day of walking for ≥3 days/week for 12 weeks. The primary outcome was knee extension/flexion strength (Nm), measured at the velocity of 60°/s. Secondary outcomes included body composition, biomarkers (creatine kinase and creatinine), handgrip strength, and quality of life questionnaire.
Results
Both the intention-to-treat (ITT) and per-protocol (PP) analyses revealed no significant impact of SWP on knee strength compared to the placebo group over 12 weeks. On the other hand, the SWP group had significantly greater increases in right-handgrip strength by 1.94 kg (95% CI: 0.08–3.79; p = 0.041) and left-handgrip strength by 1.83 kg (0.25–3.41; p = 0.024) compared to the placebo group in the ITT population, after 12 weeks. Moreover, in the PP population, the SWP group revealed an even greater increase in right-handgrip strength by 2.07 kg (0.15–3. 98; p = 0.035) and left-handgrip strength by 2.21 kg (0.60–3.83; p = 0.008) for the 12-week period. However, this study resulted in a failure to detect significant differences in the body composition, biomarkers, quality of life questionnaire, physical activity, and caloric intake between the groups. None of the participants in the SWP group experienced any significant adverse events. In the placebo group, two participants experienced urticaria and allergic side effects, leading to their withdrawal from the study and two exhibited elevated levels of liver enzyme and increased diastolic blood pressure, respectively at 12 weeks.
Conclusion
SWP, in addition to low-intensity exercise, may enhance handgrip strengths in middle-aged and older adults with relatively lower SMM. Future studies need to use a large sample size over longer periods to validate our findings. This trial was registered at clini |
| doi_str_mv | 10.1007/s12603-023-1942-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153805342</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153805342</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-459a7dfe526c799b3e6a5d7cb9cf9dac019769251614c0b0d1d4a333e2f7dea43</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhSMEoqXwAGyQJTYsMPgvccxuGAao1KoVLevIsW8GF8ce7AQob8Lb4jAFJCTEyj_nO-fq6lTVQ0qeUULk80xZQzgmjGOqBMPqVnVIZUOwkG17u9yZVFhKIg-qezlfESJq1TZ3qwMuhWopqQ-r75thcEabaxQHdOH8xy8xjeh83mlAm69T0mZCMaDTORsP6GJKELbTB6SDRac6Z-SK5qz1gFdbsD__z7yFhI6DdZ-dnbXPL9AKvStKHN03sE_Rqzj3xfDSu1Be514b6CNexzCl6H1JuUxO-_vVnaGY4cHNeVS9f725XL_FJ2dvjterE2yEaCdcVtLSDlCzxkileg6Nrq00vTKDstoQqmSjWE0bKgzpiaVWaM45sEFa0IIfVU_2ubsUP82Qp2502YD3OkCcc8dpzVtSc8H-i7JWcMIFlwv6-C_0Ks4plEUWirGWUqoKRfeUSTHnBEO3S27U6bqjpFsq7vYVd6Xibqm4WzyPbpLnfgT72_Gr0wKwPZCLFLaQ_oz-d-oPhXawng</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2842281119</pqid></control><display><type>article</type><title>Efficacy of Silkworm Pupae Extract on Muscle Strength and Mass in Middle-Aged and Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Alma/SFX Local Collection</source><creator>Choi, J. I. ; Kweon, H. Y. ; Lee, Y. L. ; Lee, J. H. ; Lee, Sang Yeoup</creator><creatorcontrib>Choi, J. I. ; Kweon, H. Y. ; Lee, Y. L. ; Lee, J. H. ; Lee, Sang Yeoup</creatorcontrib><description>Objectives
We investigated the efficacy and safety of silkworm pupae extract (SWP) consumption for 12 weeks on muscle mass and strength in middle-aged and older individuals with relatively low skeletal muscle mass who do regular low-intensity exercise.
Design
A randomized double-blinded placebo-controlled trial.
Participants
The study was conducted with 54 participants with relatively low skeletal muscle mass (SMM) (64.4 ± 6.1 years; body mass index, 23.8 ± 2.4 kg/m
2
).
Intervention and Measurements
Participants were randomly assigned to one of two groups: 1000 mg of SWP/day plus regular exercise (SWP group, n=27) or placebo plus regular exercise (placebo group, n=27). All participants were required to engage in 30–60 minutes/day of walking for ≥3 days/week for 12 weeks. The primary outcome was knee extension/flexion strength (Nm), measured at the velocity of 60°/s. Secondary outcomes included body composition, biomarkers (creatine kinase and creatinine), handgrip strength, and quality of life questionnaire.
Results
Both the intention-to-treat (ITT) and per-protocol (PP) analyses revealed no significant impact of SWP on knee strength compared to the placebo group over 12 weeks. On the other hand, the SWP group had significantly greater increases in right-handgrip strength by 1.94 kg (95% CI: 0.08–3.79; p = 0.041) and left-handgrip strength by 1.83 kg (0.25–3.41; p = 0.024) compared to the placebo group in the ITT population, after 12 weeks. Moreover, in the PP population, the SWP group revealed an even greater increase in right-handgrip strength by 2.07 kg (0.15–3. 98; p = 0.035) and left-handgrip strength by 2.21 kg (0.60–3.83; p = 0.008) for the 12-week period. However, this study resulted in a failure to detect significant differences in the body composition, biomarkers, quality of life questionnaire, physical activity, and caloric intake between the groups. None of the participants in the SWP group experienced any significant adverse events. In the placebo group, two participants experienced urticaria and allergic side effects, leading to their withdrawal from the study and two exhibited elevated levels of liver enzyme and increased diastolic blood pressure, respectively at 12 weeks.
Conclusion
SWP, in addition to low-intensity exercise, may enhance handgrip strengths in middle-aged and older adults with relatively lower SMM. Future studies need to use a large sample size over longer periods to validate our findings. This trial was registered at clinicaltrials.gov as NCT04994054.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-023-1942-9</identifier><identifier>PMID: 37498105</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Aged ; Aging ; Animals ; Biomarkers ; Body composition ; body mass index ; Bombyx ; creatine kinase ; creatinine ; diastolic blood pressure ; Dietary Supplements ; Double-Blind Method ; Double-blind studies ; energy intake ; Exercise ; Geriatrics/Gerontology ; Hand Strength ; Humans ; Kinases ; liver ; Medicine ; Medicine & Public Health ; Middle age ; Middle Aged ; Muscle Strength ; Muscle, Skeletal - physiology ; Musculoskeletal system ; Neurosciences ; Nutrition ; Older people ; Original Research ; Physical fitness ; placebos ; Primary Care Medicine ; Pupa ; Quality of Life ; Quality of Life Research ; Questionnaires ; sample size ; Sarcopenia ; silkworms ; skeletal muscle ; urticaria</subject><ispartof>The Journal of nutrition, health & aging, 2023-07, Vol.27 (7), p.578-585</ispartof><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2023</rights><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2023.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-459a7dfe526c799b3e6a5d7cb9cf9dac019769251614c0b0d1d4a333e2f7dea43</citedby><cites>FETCH-LOGICAL-c448t-459a7dfe526c799b3e6a5d7cb9cf9dac019769251614c0b0d1d4a333e2f7dea43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-023-1942-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-023-1942-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37498105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, J. I.</creatorcontrib><creatorcontrib>Kweon, H. Y.</creatorcontrib><creatorcontrib>Lee, Y. L.</creatorcontrib><creatorcontrib>Lee, J. H.</creatorcontrib><creatorcontrib>Lee, Sang Yeoup</creatorcontrib><title>Efficacy of Silkworm Pupae Extract on Muscle Strength and Mass in Middle-Aged and Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Objectives
We investigated the efficacy and safety of silkworm pupae extract (SWP) consumption for 12 weeks on muscle mass and strength in middle-aged and older individuals with relatively low skeletal muscle mass who do regular low-intensity exercise.
Design
A randomized double-blinded placebo-controlled trial.
Participants
The study was conducted with 54 participants with relatively low skeletal muscle mass (SMM) (64.4 ± 6.1 years; body mass index, 23.8 ± 2.4 kg/m
2
).
Intervention and Measurements
Participants were randomly assigned to one of two groups: 1000 mg of SWP/day plus regular exercise (SWP group, n=27) or placebo plus regular exercise (placebo group, n=27). All participants were required to engage in 30–60 minutes/day of walking for ≥3 days/week for 12 weeks. The primary outcome was knee extension/flexion strength (Nm), measured at the velocity of 60°/s. Secondary outcomes included body composition, biomarkers (creatine kinase and creatinine), handgrip strength, and quality of life questionnaire.
Results
Both the intention-to-treat (ITT) and per-protocol (PP) analyses revealed no significant impact of SWP on knee strength compared to the placebo group over 12 weeks. On the other hand, the SWP group had significantly greater increases in right-handgrip strength by 1.94 kg (95% CI: 0.08–3.79; p = 0.041) and left-handgrip strength by 1.83 kg (0.25–3.41; p = 0.024) compared to the placebo group in the ITT population, after 12 weeks. Moreover, in the PP population, the SWP group revealed an even greater increase in right-handgrip strength by 2.07 kg (0.15–3. 98; p = 0.035) and left-handgrip strength by 2.21 kg (0.60–3.83; p = 0.008) for the 12-week period. However, this study resulted in a failure to detect significant differences in the body composition, biomarkers, quality of life questionnaire, physical activity, and caloric intake between the groups. None of the participants in the SWP group experienced any significant adverse events. In the placebo group, two participants experienced urticaria and allergic side effects, leading to their withdrawal from the study and two exhibited elevated levels of liver enzyme and increased diastolic blood pressure, respectively at 12 weeks.
Conclusion
SWP, in addition to low-intensity exercise, may enhance handgrip strengths in middle-aged and older adults with relatively lower SMM. Future studies need to use a large sample size over longer periods to validate our findings. This trial was registered at clinicaltrials.gov as NCT04994054.</description><subject>Aged</subject><subject>Aging</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Body composition</subject><subject>body mass index</subject><subject>Bombyx</subject><subject>creatine kinase</subject><subject>creatinine</subject><subject>diastolic blood pressure</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>energy intake</subject><subject>Exercise</subject><subject>Geriatrics/Gerontology</subject><subject>Hand Strength</subject><subject>Humans</subject><subject>Kinases</subject><subject>liver</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - physiology</subject><subject>Musculoskeletal system</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Older people</subject><subject>Original Research</subject><subject>Physical fitness</subject><subject>placebos</subject><subject>Primary Care Medicine</subject><subject>Pupa</subject><subject>Quality of Life</subject><subject>Quality of Life Research</subject><subject>Questionnaires</subject><subject>sample size</subject><subject>Sarcopenia</subject><subject>silkworms</subject><subject>skeletal muscle</subject><subject>urticaria</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1u1DAUhSMEoqXwAGyQJTYsMPgvccxuGAao1KoVLevIsW8GF8ce7AQob8Lb4jAFJCTEyj_nO-fq6lTVQ0qeUULk80xZQzgmjGOqBMPqVnVIZUOwkG17u9yZVFhKIg-qezlfESJq1TZ3qwMuhWopqQ-r75thcEabaxQHdOH8xy8xjeh83mlAm69T0mZCMaDTORsP6GJKELbTB6SDRac6Z-SK5qz1gFdbsD__z7yFhI6DdZ-dnbXPL9AKvStKHN03sE_Rqzj3xfDSu1Be514b6CNexzCl6H1JuUxO-_vVnaGY4cHNeVS9f725XL_FJ2dvjterE2yEaCdcVtLSDlCzxkileg6Nrq00vTKDstoQqmSjWE0bKgzpiaVWaM45sEFa0IIfVU_2ubsUP82Qp2502YD3OkCcc8dpzVtSc8H-i7JWcMIFlwv6-C_0Ks4plEUWirGWUqoKRfeUSTHnBEO3S27U6bqjpFsq7vYVd6Xibqm4WzyPbpLnfgT72_Gr0wKwPZCLFLaQ_oz-d-oPhXawng</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Choi, J. I.</creator><creator>Kweon, H. Y.</creator><creator>Lee, Y. L.</creator><creator>Lee, J. H.</creator><creator>Lee, Sang Yeoup</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20230701</creationdate><title>Efficacy of Silkworm Pupae Extract on Muscle Strength and Mass in Middle-Aged and Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial</title><author>Choi, J. I. ; Kweon, H. Y. ; Lee, Y. L. ; Lee, J. H. ; Lee, Sang Yeoup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-459a7dfe526c799b3e6a5d7cb9cf9dac019769251614c0b0d1d4a333e2f7dea43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Body composition</topic><topic>body mass index</topic><topic>Bombyx</topic><topic>creatine kinase</topic><topic>creatinine</topic><topic>diastolic blood pressure</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>energy intake</topic><topic>Exercise</topic><topic>Geriatrics/Gerontology</topic><topic>Hand Strength</topic><topic>Humans</topic><topic>Kinases</topic><topic>liver</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - physiology</topic><topic>Musculoskeletal system</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Older people</topic><topic>Original Research</topic><topic>Physical fitness</topic><topic>placebos</topic><topic>Primary Care Medicine</topic><topic>Pupa</topic><topic>Quality of Life</topic><topic>Quality of Life Research</topic><topic>Questionnaires</topic><topic>sample size</topic><topic>Sarcopenia</topic><topic>silkworms</topic><topic>skeletal muscle</topic><topic>urticaria</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, J. I.</creatorcontrib><creatorcontrib>Kweon, H. Y.</creatorcontrib><creatorcontrib>Lee, Y. L.</creatorcontrib><creatorcontrib>Lee, J. H.</creatorcontrib><creatorcontrib>Lee, Sang Yeoup</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, J. I.</au><au>Kweon, H. Y.</au><au>Lee, Y. L.</au><au>Lee, J. H.</au><au>Lee, Sang Yeoup</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Silkworm Pupae Extract on Muscle Strength and Mass in Middle-Aged and Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>27</volume><issue>7</issue><spage>578</spage><epage>585</epage><pages>578-585</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Objectives
We investigated the efficacy and safety of silkworm pupae extract (SWP) consumption for 12 weeks on muscle mass and strength in middle-aged and older individuals with relatively low skeletal muscle mass who do regular low-intensity exercise.
Design
A randomized double-blinded placebo-controlled trial.
Participants
The study was conducted with 54 participants with relatively low skeletal muscle mass (SMM) (64.4 ± 6.1 years; body mass index, 23.8 ± 2.4 kg/m
2
).
Intervention and Measurements
Participants were randomly assigned to one of two groups: 1000 mg of SWP/day plus regular exercise (SWP group, n=27) or placebo plus regular exercise (placebo group, n=27). All participants were required to engage in 30–60 minutes/day of walking for ≥3 days/week for 12 weeks. The primary outcome was knee extension/flexion strength (Nm), measured at the velocity of 60°/s. Secondary outcomes included body composition, biomarkers (creatine kinase and creatinine), handgrip strength, and quality of life questionnaire.
Results
Both the intention-to-treat (ITT) and per-protocol (PP) analyses revealed no significant impact of SWP on knee strength compared to the placebo group over 12 weeks. On the other hand, the SWP group had significantly greater increases in right-handgrip strength by 1.94 kg (95% CI: 0.08–3.79; p = 0.041) and left-handgrip strength by 1.83 kg (0.25–3.41; p = 0.024) compared to the placebo group in the ITT population, after 12 weeks. Moreover, in the PP population, the SWP group revealed an even greater increase in right-handgrip strength by 2.07 kg (0.15–3. 98; p = 0.035) and left-handgrip strength by 2.21 kg (0.60–3.83; p = 0.008) for the 12-week period. However, this study resulted in a failure to detect significant differences in the body composition, biomarkers, quality of life questionnaire, physical activity, and caloric intake between the groups. None of the participants in the SWP group experienced any significant adverse events. In the placebo group, two participants experienced urticaria and allergic side effects, leading to their withdrawal from the study and two exhibited elevated levels of liver enzyme and increased diastolic blood pressure, respectively at 12 weeks.
Conclusion
SWP, in addition to low-intensity exercise, may enhance handgrip strengths in middle-aged and older adults with relatively lower SMM. Future studies need to use a large sample size over longer periods to validate our findings. This trial was registered at clinicaltrials.gov as NCT04994054.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>37498105</pmid><doi>10.1007/s12603-023-1942-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, health & aging, 2023-07, Vol.27 (7), p.578-585 |
| issn | 1279-7707 1760-4788 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Alma/SFX Local Collection |
| subjects | Aged Aging Animals Biomarkers Body composition body mass index Bombyx creatine kinase creatinine diastolic blood pressure Dietary Supplements Double-Blind Method Double-blind studies energy intake Exercise Geriatrics/Gerontology Hand Strength Humans Kinases liver Medicine Medicine & Public Health Middle age Middle Aged Muscle Strength Muscle, Skeletal - physiology Musculoskeletal system Neurosciences Nutrition Older people Original Research Physical fitness placebos Primary Care Medicine Pupa Quality of Life Quality of Life Research Questionnaires sample size Sarcopenia silkworms skeletal muscle urticaria |
| title | Efficacy of Silkworm Pupae Extract on Muscle Strength and Mass in Middle-Aged and Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial |
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