TMT-Based Quantitative Proteomics Revealed the Antibacterial Mechanism of Cinnamaldehyde against MRSA

Natural plant extracts have demonstrated significant potential in alternative antibiotic therapies. Cinnamaldehyde (CA) has garnered considerable attention as a natural antibacterial agent. In this study, Tandem mass tag (TMT) quantitative proteomics combined with Western blot and RT-qPCR methods we...

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Veröffentlicht in:	Journal of proteome research 2024-10, Vol.23 (10), p.4637-4647
Hauptverfasser:	Chen, Xiaohui, Liu, Panpan, Wang, Jingge, He, Xiaoqiang, Wang, Jianchong, Chen, Haorong, Wang, Guiqin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - analogs & derivatives Acrolein - pharmacology Anti-Bacterial Agents - pharmacology antibiotics Bacterial Proteins - genetics Bacterial Proteins - metabolism biosynthesis cell membranes cell walls dairy cows gene expression regulation Gene Expression Regulation, Bacterial - drug effects homeostasis mastitis methicillin-resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics protein content protein synthesis proteome proteomics Proteomics - methods pyruvic acid recombinant proteins Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Tandem Mass Spectrometry teichoic acids thermal stability virulence Western blotting
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