Enteral nutrition in the management of acute pancreatitis: Modulates gut microbiome and alleviates inflammation
Enteral nutrition (EN) represents a fundamental and efficacious therapeutic approach in acute pancreatitis (AP). Our objective is to investigate the modulation of gut microbiota through enteral nutrition. This prospective observational study enrolled 35 AP patients and implemented timely enteral nut...
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| Veröffentlicht in: | Food bioscience 2024-06, Vol.59, p.103962, Article 103962 |
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| creator | Yang, Fang-Yuan Cai, Yi-Jing Niu, Xiao-Ying Wang, Shun-Fu Wang, Yu-Qi Esmie, Sabola Eluby Chen, Rui-Cong Dai, Sheng-Jie Kong, Hong-Ru Sun, Hong-Wei Shi, Ke-Qing |
| description | Enteral nutrition (EN) represents a fundamental and efficacious therapeutic approach in acute pancreatitis (AP). Our objective is to investigate the modulation of gut microbiota through enteral nutrition.
This prospective observational study enrolled 35 AP patients and implemented timely enteral nutrition intervention. Inflammatory markers, including C-reactive protein (CRP), were assessed before and after EN, while the dynamic alterations in gut microbiota were analyzed using 16S rDNA sequencing technology.
Following EN, CRP significantly decreased, effectively mitigating the inflammatory response. Due to inter-individual variations in post-enteral nutrition inflammatory status, patients were further stratified into H group (CRP≥50 mg/L) and L group (CRP |
| doi_str_mv | 10.1016/j.fbio.2024.103962 |
| format | Article |
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This prospective observational study enrolled 35 AP patients and implemented timely enteral nutrition intervention. Inflammatory markers, including C-reactive protein (CRP), were assessed before and after EN, while the dynamic alterations in gut microbiota were analyzed using 16S rDNA sequencing technology.
Following EN, CRP significantly decreased, effectively mitigating the inflammatory response. Due to inter-individual variations in post-enteral nutrition inflammatory status, patients were further stratified into H group (CRP≥50 mg/L) and L group (CRP<50 mg/L) for subsequent analysis. Comparative evaluation of clinical characteristics between the two groups revealed that the H group exhibited a significantly higher risk of adverse prognosis including respiratory dysfunction and infectious complications. Dynamic monitoring of gut microbiota demonstrated a substantial increase in microbial diversity after EN accompanied by a decrease in opportunistic pathogens such as Enterococcus, Escherella-Shigella, and Klebsiella, along with an augmentation of beneficial bacteria including Bacteroides and Fusobacterium. The composition of gut microbiota varied according to the levels of inflammation among AP patients: Shigella predominated within Group H, while Actinomyces and Enterococcus constituted the dominant bacterial population within Group L. Furthermore, Spearman correlation analysis revealed significant associations between specific microbial communities within the gut and inflammatory markers such as neutrophil to albumin ratio (NAR) and lymphocyte to C-reactive protein ratio (LCR).
EN can modify gut microbiota and alleviate inflammation, thereby affecting the severity and prognosis of AP patients.
[Display omitted]
•Enteral nutrition provides essential nutrients and energy to gut microbiome.•Enteral nutrition enhances the intestinal microecology and alleviates inflammation.•Dynamic alterations in the composition of gut microbiota during acute pancreatitis.•A significant correlation exists between gut microbiota and inflammation.</description><identifier>ISSN: 2212-4292</identifier><identifier>DOI: 10.1016/j.fbio.2024.103962</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Actinomyces ; albumins ; Bacteroides ; C-reactive protein ; digestive system ; enteral feeding ; Enterococcus ; Fusobacterium ; Gut microbiota ; inflammation ; Inflammatory responses ; intestinal microorganisms ; Klebsiella ; neutrophils ; Nutrition ; nutritional intervention ; observational studies ; Pancreas ; pancreatitis ; Prognosis ; risk ; Shigella</subject><ispartof>Food bioscience, 2024-06, Vol.59, p.103962, Article 103962</ispartof><rights>2024 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-d667d55a1928c27dfeb69619b0b7fa918ff7193164a1b18650218e654d6ffea93</cites><orcidid>0009-0005-4111-5271 ; 0009-0005-7578-7885 ; 0000-0002-5070-3834 ; 0009-0001-1414-4588</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Yang, Fang-Yuan</creatorcontrib><creatorcontrib>Cai, Yi-Jing</creatorcontrib><creatorcontrib>Niu, Xiao-Ying</creatorcontrib><creatorcontrib>Wang, Shun-Fu</creatorcontrib><creatorcontrib>Wang, Yu-Qi</creatorcontrib><creatorcontrib>Esmie, Sabola Eluby</creatorcontrib><creatorcontrib>Chen, Rui-Cong</creatorcontrib><creatorcontrib>Dai, Sheng-Jie</creatorcontrib><creatorcontrib>Kong, Hong-Ru</creatorcontrib><creatorcontrib>Sun, Hong-Wei</creatorcontrib><creatorcontrib>Shi, Ke-Qing</creatorcontrib><title>Enteral nutrition in the management of acute pancreatitis: Modulates gut microbiome and alleviates inflammation</title><title>Food bioscience</title><description>Enteral nutrition (EN) represents a fundamental and efficacious therapeutic approach in acute pancreatitis (AP). Our objective is to investigate the modulation of gut microbiota through enteral nutrition.
This prospective observational study enrolled 35 AP patients and implemented timely enteral nutrition intervention. Inflammatory markers, including C-reactive protein (CRP), were assessed before and after EN, while the dynamic alterations in gut microbiota were analyzed using 16S rDNA sequencing technology.
Following EN, CRP significantly decreased, effectively mitigating the inflammatory response. Due to inter-individual variations in post-enteral nutrition inflammatory status, patients were further stratified into H group (CRP≥50 mg/L) and L group (CRP<50 mg/L) for subsequent analysis. Comparative evaluation of clinical characteristics between the two groups revealed that the H group exhibited a significantly higher risk of adverse prognosis including respiratory dysfunction and infectious complications. Dynamic monitoring of gut microbiota demonstrated a substantial increase in microbial diversity after EN accompanied by a decrease in opportunistic pathogens such as Enterococcus, Escherella-Shigella, and Klebsiella, along with an augmentation of beneficial bacteria including Bacteroides and Fusobacterium. The composition of gut microbiota varied according to the levels of inflammation among AP patients: Shigella predominated within Group H, while Actinomyces and Enterococcus constituted the dominant bacterial population within Group L. Furthermore, Spearman correlation analysis revealed significant associations between specific microbial communities within the gut and inflammatory markers such as neutrophil to albumin ratio (NAR) and lymphocyte to C-reactive protein ratio (LCR).
EN can modify gut microbiota and alleviate inflammation, thereby affecting the severity and prognosis of AP patients.
[Display omitted]
•Enteral nutrition provides essential nutrients and energy to gut microbiome.•Enteral nutrition enhances the intestinal microecology and alleviates inflammation.•Dynamic alterations in the composition of gut microbiota during acute pancreatitis.•A significant correlation exists between gut microbiota and inflammation.</description><subject>Actinomyces</subject><subject>albumins</subject><subject>Bacteroides</subject><subject>C-reactive protein</subject><subject>digestive system</subject><subject>enteral feeding</subject><subject>Enterococcus</subject><subject>Fusobacterium</subject><subject>Gut microbiota</subject><subject>inflammation</subject><subject>Inflammatory responses</subject><subject>intestinal microorganisms</subject><subject>Klebsiella</subject><subject>neutrophils</subject><subject>Nutrition</subject><subject>nutritional intervention</subject><subject>observational studies</subject><subject>Pancreas</subject><subject>pancreatitis</subject><subject>Prognosis</subject><subject>risk</subject><subject>Shigella</subject><issn>2212-4292</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhjOARFX6B5g8sqTETuLEiAVV5UMCscBsXZxzcZXYxXYq8e9xKDO3nHT3vvfxZNkVLda0oPxmv9adcWtWsCoVSsHZWbZgjLK8YoJdZKsQ9kUK0ZRFWS8yt7URPQzETtGbaJwlxpL4iWQECzsc0UbiNAE1RSQHsMojxCQMt-TV9dMAEQPZTZGMRnmXdo9IwPYEhgGP5rdrrB5gHGGefpmdaxgCrv7yMvt42L5vnvKXt8fnzf1LrlhbxbznvOnrGqhgrWJNr7HjglPRFV2jQdBW64aKkvIKaEdbXheMtsjrqudaI4hymV2f5h68-5owRDmaoHAYwKKbgixpXTZtK-oySdlJmu4PwaOWB29G8N-SFnKGKvdyhipnqPIENZnuTiZMTxwNehmUQauwNx5VlL0z_9l_AKgsg6g</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Yang, Fang-Yuan</creator><creator>Cai, Yi-Jing</creator><creator>Niu, Xiao-Ying</creator><creator>Wang, Shun-Fu</creator><creator>Wang, Yu-Qi</creator><creator>Esmie, Sabola Eluby</creator><creator>Chen, Rui-Cong</creator><creator>Dai, Sheng-Jie</creator><creator>Kong, Hong-Ru</creator><creator>Sun, Hong-Wei</creator><creator>Shi, Ke-Qing</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0009-0005-4111-5271</orcidid><orcidid>https://orcid.org/0009-0005-7578-7885</orcidid><orcidid>https://orcid.org/0000-0002-5070-3834</orcidid><orcidid>https://orcid.org/0009-0001-1414-4588</orcidid></search><sort><creationdate>202406</creationdate><title>Enteral nutrition in the management of acute pancreatitis: Modulates gut microbiome and alleviates inflammation</title><author>Yang, Fang-Yuan ; Cai, Yi-Jing ; Niu, Xiao-Ying ; Wang, Shun-Fu ; Wang, Yu-Qi ; Esmie, Sabola Eluby ; Chen, Rui-Cong ; Dai, Sheng-Jie ; Kong, Hong-Ru ; Sun, Hong-Wei ; Shi, Ke-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-d667d55a1928c27dfeb69619b0b7fa918ff7193164a1b18650218e654d6ffea93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Actinomyces</topic><topic>albumins</topic><topic>Bacteroides</topic><topic>C-reactive protein</topic><topic>digestive system</topic><topic>enteral feeding</topic><topic>Enterococcus</topic><topic>Fusobacterium</topic><topic>Gut microbiota</topic><topic>inflammation</topic><topic>Inflammatory responses</topic><topic>intestinal microorganisms</topic><topic>Klebsiella</topic><topic>neutrophils</topic><topic>Nutrition</topic><topic>nutritional intervention</topic><topic>observational studies</topic><topic>Pancreas</topic><topic>pancreatitis</topic><topic>Prognosis</topic><topic>risk</topic><topic>Shigella</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Fang-Yuan</creatorcontrib><creatorcontrib>Cai, Yi-Jing</creatorcontrib><creatorcontrib>Niu, Xiao-Ying</creatorcontrib><creatorcontrib>Wang, Shun-Fu</creatorcontrib><creatorcontrib>Wang, Yu-Qi</creatorcontrib><creatorcontrib>Esmie, Sabola Eluby</creatorcontrib><creatorcontrib>Chen, Rui-Cong</creatorcontrib><creatorcontrib>Dai, Sheng-Jie</creatorcontrib><creatorcontrib>Kong, Hong-Ru</creatorcontrib><creatorcontrib>Sun, Hong-Wei</creatorcontrib><creatorcontrib>Shi, Ke-Qing</creatorcontrib><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Food bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Fang-Yuan</au><au>Cai, Yi-Jing</au><au>Niu, Xiao-Ying</au><au>Wang, Shun-Fu</au><au>Wang, Yu-Qi</au><au>Esmie, Sabola Eluby</au><au>Chen, Rui-Cong</au><au>Dai, Sheng-Jie</au><au>Kong, Hong-Ru</au><au>Sun, Hong-Wei</au><au>Shi, Ke-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enteral nutrition in the management of acute pancreatitis: Modulates gut microbiome and alleviates inflammation</atitle><jtitle>Food bioscience</jtitle><date>2024-06</date><risdate>2024</risdate><volume>59</volume><spage>103962</spage><pages>103962-</pages><artnum>103962</artnum><issn>2212-4292</issn><abstract>Enteral nutrition (EN) represents a fundamental and efficacious therapeutic approach in acute pancreatitis (AP). Our objective is to investigate the modulation of gut microbiota through enteral nutrition.
This prospective observational study enrolled 35 AP patients and implemented timely enteral nutrition intervention. Inflammatory markers, including C-reactive protein (CRP), were assessed before and after EN, while the dynamic alterations in gut microbiota were analyzed using 16S rDNA sequencing technology.
Following EN, CRP significantly decreased, effectively mitigating the inflammatory response. Due to inter-individual variations in post-enteral nutrition inflammatory status, patients were further stratified into H group (CRP≥50 mg/L) and L group (CRP<50 mg/L) for subsequent analysis. Comparative evaluation of clinical characteristics between the two groups revealed that the H group exhibited a significantly higher risk of adverse prognosis including respiratory dysfunction and infectious complications. Dynamic monitoring of gut microbiota demonstrated a substantial increase in microbial diversity after EN accompanied by a decrease in opportunistic pathogens such as Enterococcus, Escherella-Shigella, and Klebsiella, along with an augmentation of beneficial bacteria including Bacteroides and Fusobacterium. The composition of gut microbiota varied according to the levels of inflammation among AP patients: Shigella predominated within Group H, while Actinomyces and Enterococcus constituted the dominant bacterial population within Group L. Furthermore, Spearman correlation analysis revealed significant associations between specific microbial communities within the gut and inflammatory markers such as neutrophil to albumin ratio (NAR) and lymphocyte to C-reactive protein ratio (LCR).
EN can modify gut microbiota and alleviate inflammation, thereby affecting the severity and prognosis of AP patients.
[Display omitted]
•Enteral nutrition provides essential nutrients and energy to gut microbiome.•Enteral nutrition enhances the intestinal microecology and alleviates inflammation.•Dynamic alterations in the composition of gut microbiota during acute pancreatitis.•A significant correlation exists between gut microbiota and inflammation.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.fbio.2024.103962</doi><orcidid>https://orcid.org/0009-0005-4111-5271</orcidid><orcidid>https://orcid.org/0009-0005-7578-7885</orcidid><orcidid>https://orcid.org/0000-0002-5070-3834</orcidid><orcidid>https://orcid.org/0009-0001-1414-4588</orcidid></addata></record> |
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| subjects | Actinomyces albumins Bacteroides C-reactive protein digestive system enteral feeding Enterococcus Fusobacterium Gut microbiota inflammation Inflammatory responses intestinal microorganisms Klebsiella neutrophils Nutrition nutritional intervention observational studies Pancreas pancreatitis Prognosis risk Shigella |
| title | Enteral nutrition in the management of acute pancreatitis: Modulates gut microbiome and alleviates inflammation |
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