Kellerin alleviates cerebral ischemic injury by inhibiting ferroptosis via targeting Akt-mediated transcriptional activation of Nrf2

Ischemic stroke (IS) is characterized as a detrimental cerebrovascular disease with high mortality and disability. Ferroptosis is a novel mechanism involved in neuronal death. There is a close connection between IS and ferroptosis, and inhibiting ferroptosis may provide an effective strategy for tre...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-06, Vol.128, p.155406-155406, Article 155406
Hauptverfasser:	Mi, Yan, Wang, Yongping, Liu, Yeshu, Dang, Wen, Xu, Libin, Tan, Shaowen, Liu, Linge, Chen, Gang, Liu, Yueyang, Li, Ning, Hou, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients Akt Animals antioxidants Brain Ischemia - drug therapy Cell Line, Tumor death drugs edema ferroptosis Ferroptosis - drug effects Ferula sinkiangensis Humans infarction Infarction, Middle Cerebral Artery - drug therapy ischemia Ischemic stroke Kellerin, Ferroptosis Male Mice Mice, Inbred C57BL mitochondria Mitochondria ROS Molecular Docking Simulation mortality neurons Neuroprotective Agents - pharmacology NF-E2-Related Factor 2 - metabolism Nrf2 phosphorylation Proto-Oncogene Proteins c-akt - metabolism Reperfusion Injury - drug therapy Signal Transduction - drug effects stroke therapeutics transcriptional activation Transcriptional Activation - drug effects
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