Dual-Level Reactive Oxygen Species Amplifier for Enhanced Photothermal–Chemodynamic Therapy
Chemodynamic therapy is an appealing modality in cancer treatment. However, its therapeutic effectiveness is impeded by insufficient catalytic efficiency and overexpression of glutathione (GSH) at the tumor site. In this study, a poly(o-phenylenediamine) (PoPD)@copper sulfide (CuS) nanoplatform was...
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| Veröffentlicht in: | Langmuir 2024-09, Vol.40 (36), p.19125-19133 |
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| creator | Sun, Xiaohuan Zhang, Qing Bao, Yanli Ye, Qianyun Han, Jie Guo, Rong |
| description | Chemodynamic therapy is an appealing modality in cancer treatment. However, its therapeutic effectiveness is impeded by insufficient catalytic efficiency and overexpression of glutathione (GSH) at the tumor site. In this study, a poly(o-phenylenediamine) (PoPD)@copper sulfide (CuS) nanoplatform was developed as dual-level reactive oxygen species (ROS) amplifier for enhanced photothermal–chemodynamic therapy. The PoPD@CuS nanoplatform exhibited photothermal performance, chemodynamic performance, and GSH-depleting capability. Alongside its improved photothermal conversion efficiency with tumor pH-responsiveness, the photothermal behavior of PoPD@CuS could elevate chemodynamic activity by regulating the temperature spatiotemporally, leading to increased ROS production. Moreover, GSH depletion of PoPD@CuS could suppress ROS scavenging, further enhancing oxidative stress in the tumor region. Consequently, functioning as a dual-level ROS amplifier, PoPD@CuS showcased remarkable effectiveness in photothermal–chemodynamic combination therapy. |
| doi_str_mv | 10.1021/acs.langmuir.4c02245 |
| format | Article |
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However, its therapeutic effectiveness is impeded by insufficient catalytic efficiency and overexpression of glutathione (GSH) at the tumor site. In this study, a poly(o-phenylenediamine) (PoPD)@copper sulfide (CuS) nanoplatform was developed as dual-level reactive oxygen species (ROS) amplifier for enhanced photothermal–chemodynamic therapy. The PoPD@CuS nanoplatform exhibited photothermal performance, chemodynamic performance, and GSH-depleting capability. Alongside its improved photothermal conversion efficiency with tumor pH-responsiveness, the photothermal behavior of PoPD@CuS could elevate chemodynamic activity by regulating the temperature spatiotemporally, leading to increased ROS production. Moreover, GSH depletion of PoPD@CuS could suppress ROS scavenging, further enhancing oxidative stress in the tumor region. 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However, its therapeutic effectiveness is impeded by insufficient catalytic efficiency and overexpression of glutathione (GSH) at the tumor site. In this study, a poly(o-phenylenediamine) (PoPD)@copper sulfide (CuS) nanoplatform was developed as dual-level reactive oxygen species (ROS) amplifier for enhanced photothermal–chemodynamic therapy. The PoPD@CuS nanoplatform exhibited photothermal performance, chemodynamic performance, and GSH-depleting capability. Alongside its improved photothermal conversion efficiency with tumor pH-responsiveness, the photothermal behavior of PoPD@CuS could elevate chemodynamic activity by regulating the temperature spatiotemporally, leading to increased ROS production. Moreover, GSH depletion of PoPD@CuS could suppress ROS scavenging, further enhancing oxidative stress in the tumor region. Consequently, functioning as a dual-level ROS amplifier, PoPD@CuS showcased remarkable effectiveness in photothermal–chemodynamic combination therapy.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>cancer therapy</subject><subject>catalytic activity</subject><subject>Cell Line, Tumor</subject><subject>Copper - chemistry</subject><subject>Copper - pharmacology</subject><subject>glutathione</subject><subject>Glutathione - chemistry</subject><subject>Glutathione - metabolism</subject><subject>Humans</subject><subject>Mice</subject><subject>neoplasms</subject><subject>oxidative stress</subject><subject>Phenylenediamines - chemistry</subject><subject>Phenylenediamines - pharmacology</subject><subject>Phototherapy - methods</subject><subject>Photothermal Therapy</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>sulfides</subject><subject>temperature</subject><issn>0743-7463</issn><issn>1520-5827</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxEAQRRtRdHz8gUiWbjJWd7rTyVLG8QEDIzouJVQ6FSeSl92JODv_wT_0S4zM6FJXBcW5VXAPY8ccxhwEP0PjxiXWT1Vf2LE0IIRUW2zElQBfRUJvsxFoGfhahsEe23fuGQDiQMa7bC-IeQxK8RF7vOix9Gf0SqV3R2i64pW8-dvqiWrvviVTkPPOq7Ys8oKslzfWm9ZLrA1l3u2y6ZpuSbbC8vP9Y7KkqslWNVaF8RbDGtvVIdvJsXR0tJkH7OFyuphc-7P51c3kfOajCKHzhYlERCACJXSmFUqegQ5TmaOJwhBMjphGGjWqTBIXqQSkXEcmT-M0FnEWHLDT9d3WNi89uS6pCmeoHPqhpndJwFWgI6U5_x-FeCA5aDWgco0a2zhnKU9aW1RoVwmH5NtBMjhIfhwkGwdD7GTzoU8ryn5DP6UPAKyB7_hz09t66Obvm1_En5gh</recordid><startdate>20240910</startdate><enddate>20240910</enddate><creator>Sun, Xiaohuan</creator><creator>Zhang, Qing</creator><creator>Bao, Yanli</creator><creator>Ye, Qianyun</creator><creator>Han, Jie</creator><creator>Guo, Rong</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-0050-7509</orcidid><orcidid>https://orcid.org/0000-0002-0807-1490</orcidid><orcidid>https://orcid.org/0000-0001-5655-131X</orcidid></search><sort><creationdate>20240910</creationdate><title>Dual-Level Reactive Oxygen Species Amplifier for Enhanced Photothermal–Chemodynamic Therapy</title><author>Sun, Xiaohuan ; Zhang, Qing ; Bao, Yanli ; Ye, Qianyun ; Han, Jie ; Guo, Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a260t-2c828e023527d75a41d076b4fac8660cfaab87a7a5d4e12b40aef78cfb9b929d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>cancer therapy</topic><topic>catalytic activity</topic><topic>Cell Line, Tumor</topic><topic>Copper - chemistry</topic><topic>Copper - pharmacology</topic><topic>glutathione</topic><topic>Glutathione - chemistry</topic><topic>Glutathione - metabolism</topic><topic>Humans</topic><topic>Mice</topic><topic>neoplasms</topic><topic>oxidative stress</topic><topic>Phenylenediamines - chemistry</topic><topic>Phenylenediamines - pharmacology</topic><topic>Phototherapy - methods</topic><topic>Photothermal Therapy</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>sulfides</topic><topic>temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Xiaohuan</creatorcontrib><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Bao, Yanli</creatorcontrib><creatorcontrib>Ye, Qianyun</creatorcontrib><creatorcontrib>Han, Jie</creatorcontrib><creatorcontrib>Guo, Rong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Xiaohuan</au><au>Zhang, Qing</au><au>Bao, Yanli</au><au>Ye, Qianyun</au><au>Han, Jie</au><au>Guo, Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual-Level Reactive Oxygen Species Amplifier for Enhanced Photothermal–Chemodynamic Therapy</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2024-09-10</date><risdate>2024</risdate><volume>40</volume><issue>36</issue><spage>19125</spage><epage>19133</epage><pages>19125-19133</pages><issn>0743-7463</issn><issn>1520-5827</issn><eissn>1520-5827</eissn><abstract>Chemodynamic therapy is an appealing modality in cancer treatment. However, its therapeutic effectiveness is impeded by insufficient catalytic efficiency and overexpression of glutathione (GSH) at the tumor site. In this study, a poly(o-phenylenediamine) (PoPD)@copper sulfide (CuS) nanoplatform was developed as dual-level reactive oxygen species (ROS) amplifier for enhanced photothermal–chemodynamic therapy. The PoPD@CuS nanoplatform exhibited photothermal performance, chemodynamic performance, and GSH-depleting capability. Alongside its improved photothermal conversion efficiency with tumor pH-responsiveness, the photothermal behavior of PoPD@CuS could elevate chemodynamic activity by regulating the temperature spatiotemporally, leading to increased ROS production. Moreover, GSH depletion of PoPD@CuS could suppress ROS scavenging, further enhancing oxidative stress in the tumor region. Consequently, functioning as a dual-level ROS amplifier, PoPD@CuS showcased remarkable effectiveness in photothermal–chemodynamic combination therapy.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>39190551</pmid><doi>10.1021/acs.langmuir.4c02245</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0050-7509</orcidid><orcidid>https://orcid.org/0000-0002-0807-1490</orcidid><orcidid>https://orcid.org/0000-0001-5655-131X</orcidid></addata></record> |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology cancer therapy catalytic activity Cell Line, Tumor Copper - chemistry Copper - pharmacology glutathione Glutathione - chemistry Glutathione - metabolism Humans Mice neoplasms oxidative stress Phenylenediamines - chemistry Phenylenediamines - pharmacology Phototherapy - methods Photothermal Therapy reactive oxygen species Reactive Oxygen Species - metabolism sulfides temperature |
| title | Dual-Level Reactive Oxygen Species Amplifier for Enhanced Photothermal–Chemodynamic Therapy |
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