Effect of Pentaclethra macrophyla Benth. Leaf on expression of P53, IRS, HsD17β2, FTO, and CYP11a genes in letrozole-induced polycystic ovarian syndrome rats

Hyperandrogenism and menstruation difficulties are the hallmarks of polycystic ovarian syndrome (PCOS), a disorder affecting women in their reproductive years. The purpose of this study is to determine if Pentaclethra macrophylla leaf extract is beneficial in treating letrozole-induced PCOS rats. To...

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Veröffentlicht in:	Comparative clinical pathology 2024-06, Vol.33 (3), p.355-366
Hauptverfasser:	Ogunlakin, Akingbolabo Daniel, Ojo, Oluwafemi Adeleke, Osagie, Precious Oreoluwa, Ubogu, Oghenetega, Adegoke, Adeyemi Abdullahi, Ogunlakin, Oluwaseun A.
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol blood Body fat cell biology Cholesterol monooxygenase (side-chain-cleaving) citrates Clomiphene Cytology Enzyme-linked immunosorbent assay estradiol Follicle-stimulating hormone follicular development Gene expression Genes Hematology Hydroxyl radicals hyperandrogenism insulin receptor substrate proteins leaf extracts Leaves Luteinizing hormone Medicine Medicine & Public Health Menstruation methanol Oncology Original Article Ovaries Pathology Pentaclethra macrophylla Plant extracts Polycystic ovary syndrome Testosterone therapeutics
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