Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing
Bacterial infection, hyperinflammation and hypoxia, which can lead to amputation in severe cases, are frequently observed in diabetic wounds, and this has been a critical issue facing the repair of chronic skin injuries. In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (T...
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| Veröffentlicht in: | International journal of biological macromolecules 2024-05, Vol.268 (Pt 2), p.131670-131670, Article 131670 |
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| creator | Chai, Guodong Wang, Ning Xu, Meiling Ma, Lina Liu, Xinglong Ding, Qiteng Zhang, Shuai Li, Anning Xia, Guofeng Zhao, Yingchun Liu, Wencong Liang, Dadong Ding, Chuanbo |
| description | Bacterial infection, hyperinflammation and hypoxia, which can lead to amputation in severe cases, are frequently observed in diabetic wounds, and this has been a critical issue facing the repair of chronic skin injuries. In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (TAX) with a drug loading of 41.94 ± 2.60 % was prepared. In addition, it has excellent catalase activity, and by constructing an oxygen-releasing hydrogel (PTH) system with calcium peroxide (CaO2), it can be used as a nano-enzyme to promote the generation of oxygen from hydrogen peroxide (H2O2) to provide sufficient oxygen to the wound, and at the same time, solve the problem of the oxidative stress damage caused by excess H2O2 to the cells during the oxygen-releasing process. On the other hand, TAX and HKUST-1 in PTH synergistically promoted antimicrobial and anti-oxidative stress properties, and the bacterial inhibition rate against Staphylococcus aureus and Escherichia coli reached 90 %. In vivo experiments have shown that PTH hydrogel is able to treat diabetic skin repair by inhibiting the expression of inflammation-related proteins and promoting epidermal neogenesis, angiogenesis and collagen deposition. |
| doi_str_mv | 10.1016/j.ijbiomac.2024.131670 |
| format | Article |
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In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (TAX) with a drug loading of 41.94 ± 2.60 % was prepared. In addition, it has excellent catalase activity, and by constructing an oxygen-releasing hydrogel (PTH) system with calcium peroxide (CaO2), it can be used as a nano-enzyme to promote the generation of oxygen from hydrogen peroxide (H2O2) to provide sufficient oxygen to the wound, and at the same time, solve the problem of the oxidative stress damage caused by excess H2O2 to the cells during the oxygen-releasing process. On the other hand, TAX and HKUST-1 in PTH synergistically promoted antimicrobial and anti-oxidative stress properties, and the bacterial inhibition rate against Staphylococcus aureus and Escherichia coli reached 90 %. In vivo experiments have shown that PTH hydrogel is able to treat diabetic skin repair by inhibiting the expression of inflammation-related proteins and promoting epidermal neogenesis, angiogenesis and collagen deposition.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2024.131670</identifier><identifier>PMID: 38643919</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>alginates ; Alginates - chemistry ; Alginates - pharmacology ; amputation ; angiogenesis ; Animals ; Anti-bacteria ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Anti-inflammation ; bacterial infections ; calcium peroxide ; catalase ; chitosan ; Chitosan - analogs & derivatives ; Chitosan - chemistry ; Chitosan - pharmacology ; collagen ; copper ; Diabetes Mellitus, Experimental - drug therapy ; Diabetic wound ; drugs ; Escherichia coli ; Escherichia coli - drug effects ; Humans ; hydrogels ; Hydrogels - chemistry ; Hydrogels - pharmacology ; hydrogen peroxide ; hypoxia ; Mice ; Multifunctional hydrogel ; Nano enzyme ; oxidative stress ; Oxidative Stress - drug effects ; oxygen ; Oxygen-releasing ; Polyvinyl Alcohol - chemistry ; Quercetin - analogs & derivatives ; Quercetin - chemistry ; Quercetin - pharmacology ; Rats ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; taxifolin ; Wound Healing - drug effects</subject><ispartof>International journal of biological macromolecules, 2024-05, Vol.268 (Pt 2), p.131670-131670, Article 131670</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c348t-ae6dafd633886a067879fa1f2efa3493d8b663118e543332dc47412bffb8e72a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141813024024759$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38643919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chai, Guodong</creatorcontrib><creatorcontrib>Wang, Ning</creatorcontrib><creatorcontrib>Xu, Meiling</creatorcontrib><creatorcontrib>Ma, Lina</creatorcontrib><creatorcontrib>Liu, Xinglong</creatorcontrib><creatorcontrib>Ding, Qiteng</creatorcontrib><creatorcontrib>Zhang, Shuai</creatorcontrib><creatorcontrib>Li, Anning</creatorcontrib><creatorcontrib>Xia, Guofeng</creatorcontrib><creatorcontrib>Zhao, Yingchun</creatorcontrib><creatorcontrib>Liu, Wencong</creatorcontrib><creatorcontrib>Liang, Dadong</creatorcontrib><creatorcontrib>Ding, Chuanbo</creatorcontrib><title>Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Bacterial infection, hyperinflammation and hypoxia, which can lead to amputation in severe cases, are frequently observed in diabetic wounds, and this has been a critical issue facing the repair of chronic skin injuries. In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (TAX) with a drug loading of 41.94 ± 2.60 % was prepared. In addition, it has excellent catalase activity, and by constructing an oxygen-releasing hydrogel (PTH) system with calcium peroxide (CaO2), it can be used as a nano-enzyme to promote the generation of oxygen from hydrogen peroxide (H2O2) to provide sufficient oxygen to the wound, and at the same time, solve the problem of the oxidative stress damage caused by excess H2O2 to the cells during the oxygen-releasing process. On the other hand, TAX and HKUST-1 in PTH synergistically promoted antimicrobial and anti-oxidative stress properties, and the bacterial inhibition rate against Staphylococcus aureus and Escherichia coli reached 90 %. In vivo experiments have shown that PTH hydrogel is able to treat diabetic skin repair by inhibiting the expression of inflammation-related proteins and promoting epidermal neogenesis, angiogenesis and collagen deposition.</description><subject>alginates</subject><subject>Alginates - chemistry</subject><subject>Alginates - pharmacology</subject><subject>amputation</subject><subject>angiogenesis</subject><subject>Animals</subject><subject>Anti-bacteria</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-inflammation</subject><subject>bacterial infections</subject><subject>calcium peroxide</subject><subject>catalase</subject><subject>chitosan</subject><subject>Chitosan - analogs & derivatives</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - pharmacology</subject><subject>collagen</subject><subject>copper</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetic wound</subject><subject>drugs</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Humans</subject><subject>hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogels - pharmacology</subject><subject>hydrogen peroxide</subject><subject>hypoxia</subject><subject>Mice</subject><subject>Multifunctional hydrogel</subject><subject>Nano enzyme</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>oxygen</subject><subject>Oxygen-releasing</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Quercetin - analogs & derivatives</subject><subject>Quercetin - chemistry</subject><subject>Quercetin - pharmacology</subject><subject>Rats</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>taxifolin</subject><subject>Wound Healing - drug effects</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQQC1ERZeWX6h8LIfs2nHWcW6gqlBEJSq1PVuOPd545djFTgrhF_hpXG3LtafRjN7MaOYhdEbJmhLKN_u12_cujkqva1I3a8oob8kbtKKi7SpCCHuLVoQ2tBKUkWP0Pud9qfItFe_QMRO8YR3tVujvTfQLPn90YfFYeR2H6D9ucjRuHku-c0FNsNEq9fH3MsI0FEwPbopZBTzOfnJ2DnpyMSiPh8WkuAOPfVTGhR2--n5_e1dRHFSIEP6UARnbmLBxqofJafwrzsHgAZQv-Ck6sspn-PAcT9D9l8u7i6vq-sfXbxefryvNGjFVCrhR1nDGhOCK8LZcbBW1NVjFmo4Z0XPOKBWwbRhjtdFN29C6t7YX0NaKnaDzw9yHFH_OkCc5uqzBexUgzlkyumWtqMtHX0dJw9q2q0VXUH5AdYo5J7DyIblRpUVSIp-cyb18cSafnMmDs9J49rxj7kcw_9teJBXg0wGA8pRHB0lm7SBoMC6BnqSJ7rUd_wCY3q3D</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Chai, Guodong</creator><creator>Wang, Ning</creator><creator>Xu, Meiling</creator><creator>Ma, Lina</creator><creator>Liu, Xinglong</creator><creator>Ding, Qiteng</creator><creator>Zhang, Shuai</creator><creator>Li, Anning</creator><creator>Xia, Guofeng</creator><creator>Zhao, Yingchun</creator><creator>Liu, Wencong</creator><creator>Liang, Dadong</creator><creator>Ding, Chuanbo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202405</creationdate><title>Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing</title><author>Chai, Guodong ; Wang, Ning ; Xu, Meiling ; Ma, Lina ; Liu, Xinglong ; Ding, Qiteng ; Zhang, Shuai ; Li, Anning ; Xia, Guofeng ; Zhao, Yingchun ; Liu, Wencong ; Liang, Dadong ; Ding, Chuanbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-ae6dafd633886a067879fa1f2efa3493d8b663118e543332dc47412bffb8e72a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>alginates</topic><topic>Alginates - chemistry</topic><topic>Alginates - pharmacology</topic><topic>amputation</topic><topic>angiogenesis</topic><topic>Animals</topic><topic>Anti-bacteria</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-inflammation</topic><topic>bacterial infections</topic><topic>calcium peroxide</topic><topic>catalase</topic><topic>chitosan</topic><topic>Chitosan - analogs & derivatives</topic><topic>Chitosan - chemistry</topic><topic>Chitosan - pharmacology</topic><topic>collagen</topic><topic>copper</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetic wound</topic><topic>drugs</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Humans</topic><topic>hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogels - pharmacology</topic><topic>hydrogen peroxide</topic><topic>hypoxia</topic><topic>Mice</topic><topic>Multifunctional hydrogel</topic><topic>Nano enzyme</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>oxygen</topic><topic>Oxygen-releasing</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Quercetin - analogs & derivatives</topic><topic>Quercetin - chemistry</topic><topic>Quercetin - pharmacology</topic><topic>Rats</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>taxifolin</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chai, Guodong</creatorcontrib><creatorcontrib>Wang, Ning</creatorcontrib><creatorcontrib>Xu, Meiling</creatorcontrib><creatorcontrib>Ma, Lina</creatorcontrib><creatorcontrib>Liu, Xinglong</creatorcontrib><creatorcontrib>Ding, Qiteng</creatorcontrib><creatorcontrib>Zhang, Shuai</creatorcontrib><creatorcontrib>Li, Anning</creatorcontrib><creatorcontrib>Xia, Guofeng</creatorcontrib><creatorcontrib>Zhao, Yingchun</creatorcontrib><creatorcontrib>Liu, Wencong</creatorcontrib><creatorcontrib>Liang, Dadong</creatorcontrib><creatorcontrib>Ding, Chuanbo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chai, Guodong</au><au>Wang, Ning</au><au>Xu, Meiling</au><au>Ma, Lina</au><au>Liu, Xinglong</au><au>Ding, Qiteng</au><au>Zhang, Shuai</au><au>Li, Anning</au><au>Xia, Guofeng</au><au>Zhao, Yingchun</au><au>Liu, Wencong</au><au>Liang, Dadong</au><au>Ding, Chuanbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2024-05</date><risdate>2024</risdate><volume>268</volume><issue>Pt 2</issue><spage>131670</spage><epage>131670</epage><pages>131670-131670</pages><artnum>131670</artnum><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Bacterial infection, hyperinflammation and hypoxia, which can lead to amputation in severe cases, are frequently observed in diabetic wounds, and this has been a critical issue facing the repair of chronic skin injuries. In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (TAX) with a drug loading of 41.94 ± 2.60 % was prepared. In addition, it has excellent catalase activity, and by constructing an oxygen-releasing hydrogel (PTH) system with calcium peroxide (CaO2), it can be used as a nano-enzyme to promote the generation of oxygen from hydrogen peroxide (H2O2) to provide sufficient oxygen to the wound, and at the same time, solve the problem of the oxidative stress damage caused by excess H2O2 to the cells during the oxygen-releasing process. On the other hand, TAX and HKUST-1 in PTH synergistically promoted antimicrobial and anti-oxidative stress properties, and the bacterial inhibition rate against Staphylococcus aureus and Escherichia coli reached 90 %. In vivo experiments have shown that PTH hydrogel is able to treat diabetic skin repair by inhibiting the expression of inflammation-related proteins and promoting epidermal neogenesis, angiogenesis and collagen deposition.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38643919</pmid><doi>10.1016/j.ijbiomac.2024.131670</doi><tpages>1</tpages></addata></record> |
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| subjects | alginates Alginates - chemistry Alginates - pharmacology amputation angiogenesis Animals Anti-bacteria Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-inflammation bacterial infections calcium peroxide catalase chitosan Chitosan - analogs & derivatives Chitosan - chemistry Chitosan - pharmacology collagen copper Diabetes Mellitus, Experimental - drug therapy Diabetic wound drugs Escherichia coli Escherichia coli - drug effects Humans hydrogels Hydrogels - chemistry Hydrogels - pharmacology hydrogen peroxide hypoxia Mice Multifunctional hydrogel Nano enzyme oxidative stress Oxidative Stress - drug effects oxygen Oxygen-releasing Polyvinyl Alcohol - chemistry Quercetin - analogs & derivatives Quercetin - chemistry Quercetin - pharmacology Rats Staphylococcus aureus Staphylococcus aureus - drug effects taxifolin Wound Healing - drug effects |
| title | Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing |
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