A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies

Plasmodium vivax malaria is increasingly recognized as a major global health problem and the socio-economic impact of P.vivax-induced burden is huge. Vaccine development against P. vivax malaria has been hampered by the lack of an in vitro culture system and poor access to P. vivax sporozoites. The...

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Veröffentlicht in:	Vaccine 2024-03, Vol.42 (7), p.1785-1792
Hauptverfasser:	Faber, Bart W., Yeoh, Lee M., Kurtovic, Liriye, Mol, Wim E.M., Poelert, Martin, Smits, Elly, Rodriguez Garcia, Roberto, Mandalawi-Van der Eijk, Marjolein, van der Werff, Nicole, Voorberg-van der Wel, Annemarie, Remarque, Edmond J., Beeson, James G., Kocken, Clemens H.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients Adjuvants Adjuvants, Immunologic Alleles Animals Antibodies Antibodies, Protozoan Antigens Antigens, Protozoan - genetics blood Delayed response Economic impact Esterification fatty acids Genes Global health humoral immunity Immune response Immune response (humoral) Immune system Immunization Impact analysis Infections Laboratory animals Malaria Malaria Vaccines Malaria, Falciparum - prevention & control Malaria, Vivax - prevention & control Membrane Proteins - genetics Mixtures Mortality Parasites Plasmodium falciparum Plasmodium vivax Polymorphism Proteins Protozoan Proteins - genetics Public health Rabbits Raffinose socioeconomic factors Sporozoites Sulfates Vaccine development Vaccines Vector-borne diseases
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