Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials
Several experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive. Therefore, this study aimed to explore the impact of N. sativa supplementation on the lipid profile of...
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| Veröffentlicht in: | Clinical nutrition ESPEN 2024-06, Vol.61, p.168-180 |
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| container_title | Clinical nutrition ESPEN |
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| creator | Rounagh, Mahsa Musazadeh, Vali Hosseininejad-Mohebati, Ali Falahatzadeh, Maryam Kavyani, Zeynab Rostami, Reza Bijan Vajdi, Mahdi |
| description | Several experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive. Therefore, this study aimed to explore the impact of N. sativa supplementation on the lipid profile of adult participants.
We searched Scopus, Web of Science, PubMed, Cochrane, and Web of Science databases until December 2022. Random effects models were used, and pooled data were determined as standardized mean differences with a 95% confidence interval.
The findings of 34 studies with 2278 participants revealed that N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: −1.78; 95% CI: −2.20, −1.37, p |
| doi_str_mv | 10.1016/j.clnesp.2024.03.020 |
| format | Article |
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We searched Scopus, Web of Science, PubMed, Cochrane, and Web of Science databases until December 2022. Random effects models were used, and pooled data were determined as standardized mean differences with a 95% confidence interval.
The findings of 34 studies with 2278 participants revealed that N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: −1.78; 95% CI: −2.20, −1.37, p < 0.001), triglycerides (TG) (SMD: −1.2725; 95% CI: −1.67, −0.83, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD: −2.45; 95% CI: −3.06, −1.85; p < 0.001) compared to control groups. However, a significant increase was found in high-density lipoprotein cholesterol (HDL-C) (SMD: 0.79; 95% CI: 0.38, 1.20, p < 0.001).
N. sativa has improved effects on TG, LDL-C, TC, and HDL-C levels. Overall, N. sativa may be suggested as an adjuvant anti-hyperlipidemic agent.</description><identifier>ISSN: 2405-4577</identifier><identifier>EISSN: 2405-4577</identifier><identifier>DOI: 10.1016/j.clnesp.2024.03.020</identifier><identifier>PMID: 38777430</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>adjuvants ; Adult ; adults ; Blood lipids ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; clinical nutrition ; confidence interval ; Dietary Supplements ; high density lipoprotein cholesterol ; Humans ; Hyperlipidemia ; lipid composition ; Lipids - blood ; low density lipoprotein cholesterol ; Meta-analysis ; Nigella sativa ; Nigella sativa - chemistry ; Randomized Controlled Trials as Topic ; Systematic review ; Triglycerides - blood</subject><ispartof>Clinical nutrition ESPEN, 2024-06, Vol.61, p.168-180</ispartof><rights>2024 European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c259t-61aa62ec08745b4d8a62accec2d7742fbe1450af9e967ade67b497a4ffd041553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38777430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rounagh, Mahsa</creatorcontrib><creatorcontrib>Musazadeh, Vali</creatorcontrib><creatorcontrib>Hosseininejad-Mohebati, Ali</creatorcontrib><creatorcontrib>Falahatzadeh, Maryam</creatorcontrib><creatorcontrib>Kavyani, Zeynab</creatorcontrib><creatorcontrib>Rostami, Reza Bijan</creatorcontrib><creatorcontrib>Vajdi, Mahdi</creatorcontrib><title>Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials</title><title>Clinical nutrition ESPEN</title><addtitle>Clin Nutr ESPEN</addtitle><description>Several experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive. Therefore, this study aimed to explore the impact of N. sativa supplementation on the lipid profile of adult participants.
We searched Scopus, Web of Science, PubMed, Cochrane, and Web of Science databases until December 2022. Random effects models were used, and pooled data were determined as standardized mean differences with a 95% confidence interval.
The findings of 34 studies with 2278 participants revealed that N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: −1.78; 95% CI: −2.20, −1.37, p < 0.001), triglycerides (TG) (SMD: −1.2725; 95% CI: −1.67, −0.83, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD: −2.45; 95% CI: −3.06, −1.85; p < 0.001) compared to control groups. However, a significant increase was found in high-density lipoprotein cholesterol (HDL-C) (SMD: 0.79; 95% CI: 0.38, 1.20, p < 0.001).
N. sativa has improved effects on TG, LDL-C, TC, and HDL-C levels. Overall, N. sativa may be suggested as an adjuvant anti-hyperlipidemic agent.</description><subject>adjuvants</subject><subject>Adult</subject><subject>adults</subject><subject>Blood lipids</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>clinical nutrition</subject><subject>confidence interval</subject><subject>Dietary Supplements</subject><subject>high density lipoprotein cholesterol</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>lipid composition</subject><subject>Lipids - blood</subject><subject>low density lipoprotein cholesterol</subject><subject>Meta-analysis</subject><subject>Nigella sativa</subject><subject>Nigella sativa - chemistry</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Systematic review</subject><subject>Triglycerides - blood</subject><issn>2405-4577</issn><issn>2405-4577</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1rFTEUHcRiS9t_IJKlmxnzOXnjQiilfkDRTbsOecmN5JFJxiRTef0f_l_zfFVcKQTuveGce7jndN1LggeCyfhmN5gQoSwDxZQPmA2Y4mfdGeVY9FxI-fyv_rS7LGWHceNNEyf4RXfKNlJKzvBZ9-PGOTC1oOTQZ_8VQtCo6OofWlmXJcAMsbY5RdRe8Iu3aMnJ-QAF-Yi0XUMtb9FVROtidQWLyr5UmBvHoAwPHr4jHS2aoepeRx32xf9Sy-03zf6xMUyKNacQWluz16FcdCeuFbh8qufd_fubu-uP_e2XD5-ur257Q8VU-5FoPVIweCO52HK7aZM2Bgy17TzqtkC4wNpNMI1SWxjllk9Sc-cs5kQIdt69Pu5tJ31boVQ1-2IOJkRIa1GMCCY3hAn2fygWExWCysNWfoSanErJ4NSS_azzXhGsDvGpnTrGpw7xKcxUi6_RXj0prNsZ7B_S77Aa4N0RAM2SZmxWxXiIBqzPLUNlk_-3wk_GOrCs</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Rounagh, Mahsa</creator><creator>Musazadeh, Vali</creator><creator>Hosseininejad-Mohebati, Ali</creator><creator>Falahatzadeh, Maryam</creator><creator>Kavyani, Zeynab</creator><creator>Rostami, Reza Bijan</creator><creator>Vajdi, Mahdi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202406</creationdate><title>Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials</title><author>Rounagh, Mahsa ; Musazadeh, Vali ; Hosseininejad-Mohebati, Ali ; Falahatzadeh, Maryam ; Kavyani, Zeynab ; Rostami, Reza Bijan ; Vajdi, Mahdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-61aa62ec08745b4d8a62accec2d7742fbe1450af9e967ade67b497a4ffd041553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>adjuvants</topic><topic>Adult</topic><topic>adults</topic><topic>Blood lipids</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>clinical nutrition</topic><topic>confidence interval</topic><topic>Dietary Supplements</topic><topic>high density lipoprotein cholesterol</topic><topic>Humans</topic><topic>Hyperlipidemia</topic><topic>lipid composition</topic><topic>Lipids - blood</topic><topic>low density lipoprotein cholesterol</topic><topic>Meta-analysis</topic><topic>Nigella sativa</topic><topic>Nigella sativa - chemistry</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Systematic review</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rounagh, Mahsa</creatorcontrib><creatorcontrib>Musazadeh, Vali</creatorcontrib><creatorcontrib>Hosseininejad-Mohebati, Ali</creatorcontrib><creatorcontrib>Falahatzadeh, Maryam</creatorcontrib><creatorcontrib>Kavyani, Zeynab</creatorcontrib><creatorcontrib>Rostami, Reza Bijan</creatorcontrib><creatorcontrib>Vajdi, Mahdi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical nutrition ESPEN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rounagh, Mahsa</au><au>Musazadeh, Vali</au><au>Hosseininejad-Mohebati, Ali</au><au>Falahatzadeh, Maryam</au><au>Kavyani, Zeynab</au><au>Rostami, Reza Bijan</au><au>Vajdi, Mahdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials</atitle><jtitle>Clinical nutrition ESPEN</jtitle><addtitle>Clin Nutr ESPEN</addtitle><date>2024-06</date><risdate>2024</risdate><volume>61</volume><spage>168</spage><epage>180</epage><pages>168-180</pages><issn>2405-4577</issn><eissn>2405-4577</eissn><abstract>Several experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive. Therefore, this study aimed to explore the impact of N. sativa supplementation on the lipid profile of adult participants.
We searched Scopus, Web of Science, PubMed, Cochrane, and Web of Science databases until December 2022. Random effects models were used, and pooled data were determined as standardized mean differences with a 95% confidence interval.
The findings of 34 studies with 2278 participants revealed that N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: −1.78; 95% CI: −2.20, −1.37, p < 0.001), triglycerides (TG) (SMD: −1.2725; 95% CI: −1.67, −0.83, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD: −2.45; 95% CI: −3.06, −1.85; p < 0.001) compared to control groups. However, a significant increase was found in high-density lipoprotein cholesterol (HDL-C) (SMD: 0.79; 95% CI: 0.38, 1.20, p < 0.001).
N. sativa has improved effects on TG, LDL-C, TC, and HDL-C levels. Overall, N. sativa may be suggested as an adjuvant anti-hyperlipidemic agent.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38777430</pmid><doi>10.1016/j.clnesp.2024.03.020</doi><tpages>13</tpages></addata></record> |
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| subjects | adjuvants Adult adults Blood lipids Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood clinical nutrition confidence interval Dietary Supplements high density lipoprotein cholesterol Humans Hyperlipidemia lipid composition Lipids - blood low density lipoprotein cholesterol Meta-analysis Nigella sativa Nigella sativa - chemistry Randomized Controlled Trials as Topic Systematic review Triglycerides - blood |
| title | Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials |
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