A population-based, province-wide, record-linkage interrupted time series analysis of impact of the universal seasonal influenza vaccination policy on seasonal influenza vaccine uptake among 5–64-year-olds in the province of Manitoba, Canada
•An interrupted time series analysis of impact of USIVP in Manitoba.•Increased absolute change in SIV uptake percentage in the lowest income quintiles and with less healthcare utilization among 5–17-year-olds.•An upward annual trend in SIV uptake percentage among 5–17-year-olds.•A downward annual tr...
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| Veröffentlicht in: | Vaccine 2024-03, Vol.42 (7), p.1571-1581 |
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| creator | Okoli, George N. Righolt, Christiaan H. Zhang, Geng Van Caeseele, Paul Kuo, I fan Alessi-Severini, Silvia Mahmud, Salaheddin M. |
| description | •An interrupted time series analysis of impact of USIVP in Manitoba.•Increased absolute change in SIV uptake percentage in the lowest income quintiles and with less healthcare utilization among 5–17-year-olds.•An upward annual trend in SIV uptake percentage among 5–17-year-olds.•A downward annual trend in SIV uptake percentage among 45–64-year-olds.•A downward annual trend across all strata of assessed population characteristics within all age groups in Northern Manitoba.
Universal seasonal influenza vaccination policy (USIVP) was introduced in Manitoba, Canada in 2010. Its impact on seasonal influenza vaccine (SIV) uptake remains underexplored.
We used population-wide data from Manitoba to assess the impact of the USIVP on SIV uptake. The study covered twenty influenza seasons (2000/01–2019/20). We summarized SIV uptake for influenza seasons before and after the USIVP. Utilizing a single-group interrupted time series analysis and appropriately accounting for autocorrelation, we estimated absolute change and annual trend in SIV uptake percentages among 5–17-, 18–44-, and 45–64-year-olds across strata of certain population socioeconomic and health-related characteristics following the USIVP.
Average SIV uptake percentage in all age groups was significantly higher after compared with before the USIVP. Following the USIVP, there was no significant absolute change in SIV uptake percentage among 18–44- and 45–64-year-olds overall; however, a significant decrease was observed among 18–44-year-old males in the higher income quintiles, across healthcare utilization, and in some regions of residence. A significant increase was observed among 5–17-year-olds in the lowest income quintiles, in Northern Manitoba, and among those with less healthcare utilization, and no chronic disease. Overall, there was mostly no significant annual trend in SIV uptake percentage among 18–44-year-olds, and while a significant upward and downward trend was observed among 5–17-year-olds and 45–64-year-olds, respectively, a significant downward trend was observed across all strata of population characteristics within all age groups in Northern Manitoba.
The USIVP in Manitoba was followed by an absolute increase in SIV uptake percentage only in some socioeconomically disadvantaged subpopulations among 5–17-year-olds. While there was mostly an upward annual trend in SIV uptake percentage among 5–17-year-olds, a downward trend was observed among 45–64-year-olds and across all age groups and |
| doi_str_mv | 10.1016/j.vaccine.2024.01.079 |
| format | Article |
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Universal seasonal influenza vaccination policy (USIVP) was introduced in Manitoba, Canada in 2010. Its impact on seasonal influenza vaccine (SIV) uptake remains underexplored.
We used population-wide data from Manitoba to assess the impact of the USIVP on SIV uptake. The study covered twenty influenza seasons (2000/01–2019/20). We summarized SIV uptake for influenza seasons before and after the USIVP. Utilizing a single-group interrupted time series analysis and appropriately accounting for autocorrelation, we estimated absolute change and annual trend in SIV uptake percentages among 5–17-, 18–44-, and 45–64-year-olds across strata of certain population socioeconomic and health-related characteristics following the USIVP.
Average SIV uptake percentage in all age groups was significantly higher after compared with before the USIVP. Following the USIVP, there was no significant absolute change in SIV uptake percentage among 18–44- and 45–64-year-olds overall; however, a significant decrease was observed among 18–44-year-old males in the higher income quintiles, across healthcare utilization, and in some regions of residence. A significant increase was observed among 5–17-year-olds in the lowest income quintiles, in Northern Manitoba, and among those with less healthcare utilization, and no chronic disease. Overall, there was mostly no significant annual trend in SIV uptake percentage among 18–44-year-olds, and while a significant upward and downward trend was observed among 5–17-year-olds and 45–64-year-olds, respectively, a significant downward trend was observed across all strata of population characteristics within all age groups in Northern Manitoba.
The USIVP in Manitoba was followed by an absolute increase in SIV uptake percentage only in some socioeconomically disadvantaged subpopulations among 5–17-year-olds. While there was mostly an upward annual trend in SIV uptake percentage among 5–17-year-olds, a downward trend was observed among 45–64-year-olds and across all age groups and subpopulations in socioeconomically disadvantaged Northern Manitoba. These findings are novel for Manitoba and require investigation and public health attention.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2024.01.079</identifier><identifier>PMID: 38360473</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Age ; Age groups ; autocorrelation ; Canada ; Censuses ; chronic diseases ; Chronic illnesses ; Committees ; Health care ; Health insurance ; health services ; Immunization ; Impact ; Impact analysis ; income ; Influenza ; influenza vaccination ; influenza vaccines ; Interrupted time series ; Intervention ; issues and policy ; Linkage analysis ; Logistics ; Manitoba ; Personal health ; Policy ; Population ; Population characteristics ; Pregnancy ; Primary care ; Public health ; Regression analysis ; Seasonal influenza ; Seasons ; Subpopulations ; Time series ; time series analysis ; Trends ; Vaccination ; Vaccines</subject><ispartof>Vaccine, 2024-03, Vol.42 (7), p.1571-1581</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><rights>2024. The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-8edd9232f8fbbd8100df2818fb232a327631eb496f46c6f88e2025fb40c8443c3</citedby><cites>FETCH-LOGICAL-c473t-8edd9232f8fbbd8100df2818fb232a327631eb496f46c6f88e2025fb40c8443c3</cites><orcidid>0000-0002-6543-7719 ; 0000-0002-8472-932X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X2400104X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38360473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okoli, George N.</creatorcontrib><creatorcontrib>Righolt, Christiaan H.</creatorcontrib><creatorcontrib>Zhang, Geng</creatorcontrib><creatorcontrib>Van Caeseele, Paul</creatorcontrib><creatorcontrib>Kuo, I fan</creatorcontrib><creatorcontrib>Alessi-Severini, Silvia</creatorcontrib><creatorcontrib>Mahmud, Salaheddin M.</creatorcontrib><title>A population-based, province-wide, record-linkage interrupted time series analysis of impact of the universal seasonal influenza vaccination policy on seasonal influenza vaccine uptake among 5–64-year-olds in the province of Manitoba, Canada</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>•An interrupted time series analysis of impact of USIVP in Manitoba.•Increased absolute change in SIV uptake percentage in the lowest income quintiles and with less healthcare utilization among 5–17-year-olds.•An upward annual trend in SIV uptake percentage among 5–17-year-olds.•A downward annual trend in SIV uptake percentage among 45–64-year-olds.•A downward annual trend across all strata of assessed population characteristics within all age groups in Northern Manitoba.
Universal seasonal influenza vaccination policy (USIVP) was introduced in Manitoba, Canada in 2010. Its impact on seasonal influenza vaccine (SIV) uptake remains underexplored.
We used population-wide data from Manitoba to assess the impact of the USIVP on SIV uptake. The study covered twenty influenza seasons (2000/01–2019/20). We summarized SIV uptake for influenza seasons before and after the USIVP. Utilizing a single-group interrupted time series analysis and appropriately accounting for autocorrelation, we estimated absolute change and annual trend in SIV uptake percentages among 5–17-, 18–44-, and 45–64-year-olds across strata of certain population socioeconomic and health-related characteristics following the USIVP.
Average SIV uptake percentage in all age groups was significantly higher after compared with before the USIVP. Following the USIVP, there was no significant absolute change in SIV uptake percentage among 18–44- and 45–64-year-olds overall; however, a significant decrease was observed among 18–44-year-old males in the higher income quintiles, across healthcare utilization, and in some regions of residence. A significant increase was observed among 5–17-year-olds in the lowest income quintiles, in Northern Manitoba, and among those with less healthcare utilization, and no chronic disease. Overall, there was mostly no significant annual trend in SIV uptake percentage among 18–44-year-olds, and while a significant upward and downward trend was observed among 5–17-year-olds and 45–64-year-olds, respectively, a significant downward trend was observed across all strata of population characteristics within all age groups in Northern Manitoba.
The USIVP in Manitoba was followed by an absolute increase in SIV uptake percentage only in some socioeconomically disadvantaged subpopulations among 5–17-year-olds. While there was mostly an upward annual trend in SIV uptake percentage among 5–17-year-olds, a downward trend was observed among 45–64-year-olds and across all age groups and subpopulations in socioeconomically disadvantaged Northern Manitoba. These findings are novel for Manitoba and require investigation and public health attention.</description><subject>Age</subject><subject>Age groups</subject><subject>autocorrelation</subject><subject>Canada</subject><subject>Censuses</subject><subject>chronic diseases</subject><subject>Chronic illnesses</subject><subject>Committees</subject><subject>Health care</subject><subject>Health insurance</subject><subject>health services</subject><subject>Immunization</subject><subject>Impact</subject><subject>Impact analysis</subject><subject>income</subject><subject>Influenza</subject><subject>influenza vaccination</subject><subject>influenza vaccines</subject><subject>Interrupted time series</subject><subject>Intervention</subject><subject>issues and policy</subject><subject>Linkage analysis</subject><subject>Logistics</subject><subject>Manitoba</subject><subject>Personal health</subject><subject>Policy</subject><subject>Population</subject><subject>Population characteristics</subject><subject>Pregnancy</subject><subject>Primary care</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Seasonal influenza</subject><subject>Seasons</subject><subject>Subpopulations</subject><subject>Time series</subject><subject>time series 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population-based, province-wide, record-linkage interrupted time series analysis of impact of the universal seasonal influenza vaccination policy on seasonal influenza vaccine uptake among 5–64-year-olds in the province of Manitoba, Canada</title><author>Okoli, George N. ; Righolt, Christiaan H. ; Zhang, Geng ; Van Caeseele, Paul ; Kuo, I fan ; Alessi-Severini, Silvia ; Mahmud, Salaheddin M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-8edd9232f8fbbd8100df2818fb232a327631eb496f46c6f88e2025fb40c8443c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Age groups</topic><topic>autocorrelation</topic><topic>Canada</topic><topic>Censuses</topic><topic>chronic diseases</topic><topic>Chronic illnesses</topic><topic>Committees</topic><topic>Health care</topic><topic>Health insurance</topic><topic>health services</topic><topic>Immunization</topic><topic>Impact</topic><topic>Impact analysis</topic><topic>income</topic><topic>Influenza</topic><topic>influenza vaccination</topic><topic>influenza vaccines</topic><topic>Interrupted time series</topic><topic>Intervention</topic><topic>issues and policy</topic><topic>Linkage analysis</topic><topic>Logistics</topic><topic>Manitoba</topic><topic>Personal health</topic><topic>Policy</topic><topic>Population</topic><topic>Population characteristics</topic><topic>Pregnancy</topic><topic>Primary care</topic><topic>Public health</topic><topic>Regression analysis</topic><topic>Seasonal influenza</topic><topic>Seasons</topic><topic>Subpopulations</topic><topic>Time series</topic><topic>time series analysis</topic><topic>Trends</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okoli, George N.</creatorcontrib><creatorcontrib>Righolt, Christiaan 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analysis of impact of the universal seasonal influenza vaccination policy on seasonal influenza vaccine uptake among 5–64-year-olds in the province of Manitoba, Canada</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2024-03-07</date><risdate>2024</risdate><volume>42</volume><issue>7</issue><spage>1571</spage><epage>1581</epage><pages>1571-1581</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>•An interrupted time series analysis of impact of USIVP in Manitoba.•Increased absolute change in SIV uptake percentage in the lowest income quintiles and with less healthcare utilization among 5–17-year-olds.•An upward annual trend in SIV uptake percentage among 5–17-year-olds.•A downward annual trend in SIV uptake percentage among 45–64-year-olds.•A downward annual trend across all strata of assessed population characteristics within all age groups in Northern Manitoba.
Universal seasonal influenza vaccination policy (USIVP) was introduced in Manitoba, Canada in 2010. Its impact on seasonal influenza vaccine (SIV) uptake remains underexplored.
We used population-wide data from Manitoba to assess the impact of the USIVP on SIV uptake. The study covered twenty influenza seasons (2000/01–2019/20). We summarized SIV uptake for influenza seasons before and after the USIVP. Utilizing a single-group interrupted time series analysis and appropriately accounting for autocorrelation, we estimated absolute change and annual trend in SIV uptake percentages among 5–17-, 18–44-, and 45–64-year-olds across strata of certain population socioeconomic and health-related characteristics following the USIVP.
Average SIV uptake percentage in all age groups was significantly higher after compared with before the USIVP. Following the USIVP, there was no significant absolute change in SIV uptake percentage among 18–44- and 45–64-year-olds overall; however, a significant decrease was observed among 18–44-year-old males in the higher income quintiles, across healthcare utilization, and in some regions of residence. A significant increase was observed among 5–17-year-olds in the lowest income quintiles, in Northern Manitoba, and among those with less healthcare utilization, and no chronic disease. Overall, there was mostly no significant annual trend in SIV uptake percentage among 18–44-year-olds, and while a significant upward and downward trend was observed among 5–17-year-olds and 45–64-year-olds, respectively, a significant downward trend was observed across all strata of population characteristics within all age groups in Northern Manitoba.
The USIVP in Manitoba was followed by an absolute increase in SIV uptake percentage only in some socioeconomically disadvantaged subpopulations among 5–17-year-olds. While there was mostly an upward annual trend in SIV uptake percentage among 5–17-year-olds, a downward trend was observed among 45–64-year-olds and across all age groups and subpopulations in socioeconomically disadvantaged Northern Manitoba. These findings are novel for Manitoba and require investigation and public health attention.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>38360473</pmid><doi>10.1016/j.vaccine.2024.01.079</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6543-7719</orcidid><orcidid>https://orcid.org/0000-0002-8472-932X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2024-03, Vol.42 (7), p.1571-1581 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3153779767 |
| source | Elsevier ScienceDirect Journals |
| subjects | Age Age groups autocorrelation Canada Censuses chronic diseases Chronic illnesses Committees Health care Health insurance health services Immunization Impact Impact analysis income Influenza influenza vaccination influenza vaccines Interrupted time series Intervention issues and policy Linkage analysis Logistics Manitoba Personal health Policy Population Population characteristics Pregnancy Primary care Public health Regression analysis Seasonal influenza Seasons Subpopulations Time series time series analysis Trends Vaccination Vaccines |
| title | A population-based, province-wide, record-linkage interrupted time series analysis of impact of the universal seasonal influenza vaccination policy on seasonal influenza vaccine uptake among 5–64-year-olds in the province of Manitoba, Canada |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T20%3A16%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20population-based,%20province-wide,%20record-linkage%20interrupted%20time%20series%20analysis%20of%20impact%20of%20the%20universal%20seasonal%20influenza%20vaccination%20policy%20on%20seasonal%20influenza%20vaccine%20uptake%20among%205%E2%80%9364-year-olds%20in%20the%20province%20of%20Manitoba,%20Canada&rft.jtitle=Vaccine&rft.au=Okoli,%20George%20N.&rft.date=2024-03-07&rft.volume=42&rft.issue=7&rft.spage=1571&rft.epage=1581&rft.pages=1571-1581&rft.issn=0264-410X&rft.eissn=1873-2518&rft_id=info:doi/10.1016/j.vaccine.2024.01.079&rft_dat=%3Cproquest_cross%3E2956165818%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2956165818&rft_id=info:pmid/38360473&rft_els_id=S0264410X2400104X&rfr_iscdi=true |