All-stage targeted red blood cell membrane-coated docetaxel nanocrystals for glioma treatment
Challenges for glioma treatment with nanomedicines include physio-anatomical barriers (the blood-brain barrier and blood-brain tumor barrier), low drug loading capacity, and limited circulation time. Here, a red blood cell membrane-coated docetaxel drug nanocrystal (pV-RBCm-NC(DTX)), modified with p...
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| Veröffentlicht in: | Journal of controlled release 2024-05, Vol.369, p.325-334 |
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| container_title | Journal of controlled release |
| container_volume | 369 |
| creator | Ding, Yuan Xu, Qianzhu Chai, Zhilan Wu, Sunyi Xu, Weixia Wang, Jun Zhou, Jianfen Luo, Zimiao Liu, Yu Xie, Cao Lu, Linwei Lu, Weiyue |
| description | Challenges for glioma treatment with nanomedicines include physio-anatomical barriers (the blood-brain barrier and blood-brain tumor barrier), low drug loading capacity, and limited circulation time. Here, a red blood cell membrane-coated docetaxel drug nanocrystal (pV-RBCm-NC(DTX)), modified with pHA-VAP (pV) for all-stage targeting of glioma, was designed. The NC(DTX) core exhibited a high drug loading capacity but low in vivo stability, and the RBCm coating significantly enhanced the stability and prolonged in vivo circulation. Moreover, the Y-shaped targeting ligand pV was modified by a mild avidin-biotin interaction, which endowed RBCm-NC(DTX) with superior barrier-crossing ability and therapeutic efficacy. The integration of nanocrystal technology, cell membrane coating, and the avidin-biotin insertion method into this active targeting biomimetic formulation represents a promising drug delivery strategy for glioma.
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| doi_str_mv | 10.1016/j.jconrel.2024.03.055 |
| format | Article |
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[Display omitted]</description><subject>All-stage targeted therapy</subject><subject>biomimetics</subject><subject>blood-brain barrier</subject><subject>cell membranes</subject><subject>Docetaxel</subject><subject>Drug nanocrystals</subject><subject>drugs</subject><subject>erythrocytes</subject><subject>Glioma</subject><subject>ligands</subject><subject>nanocrystals</subject><subject>nanomedicine</subject><subject>Red blood cell membrane coating</subject><subject>therapeutics</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU1PwzAMhiMEYmPwE0A9cmnJx5K2JzRNfEmTuMARRUnqTp3SZiQZYv-eVBtcOVhx5Oe1Lb8IXRNcEEzE3abYGDd4sAXFdF5gVmDOT9CUVCXL53XNT9E0cVXOBK8n6CKEDcaYs3l5jias4oKzmk_Rx8LaPES1hiwqv4YITeZTaOtckxmwNuuh114NkBunxnLjDET1DTYb1OCM3ye5DVnrfLa2netVFj2o2MMQL9FZm2pwdXxn6P3x4W35nK9en16Wi1Vu2FzEvBUt0abGHAymFGuljWqbWkOtS1VSUtFGAYgKV1QpY1grSqPHRKSvrgibodtD3613nzsIUfZdGJdPa7tdkIxwVpapNf0fxYwIQTkRCeUH1HgXgodWbn3XK7-XBMvRBLmRRxPkaILETCYTku7mOGKne2j-VL9XT8D9AYB0k68OvAymg8FA03kwUTau-2fEDw3VnYI</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Ding, Yuan</creator><creator>Xu, Qianzhu</creator><creator>Chai, Zhilan</creator><creator>Wu, Sunyi</creator><creator>Xu, Weixia</creator><creator>Wang, Jun</creator><creator>Zhou, Jianfen</creator><creator>Luo, Zimiao</creator><creator>Liu, Yu</creator><creator>Xie, Cao</creator><creator>Lu, Linwei</creator><creator>Lu, Weiyue</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20240501</creationdate><title>All-stage targeted red blood cell membrane-coated docetaxel nanocrystals for glioma treatment</title><author>Ding, Yuan ; Xu, Qianzhu ; Chai, Zhilan ; Wu, Sunyi ; Xu, Weixia ; Wang, Jun ; Zhou, Jianfen ; Luo, Zimiao ; Liu, Yu ; Xie, Cao ; Lu, Linwei ; Lu, Weiyue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-f6f1bc905ec0220babcafd9be9b7a72182daee68082aacc3f67cbacc36aacb813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>All-stage targeted therapy</topic><topic>biomimetics</topic><topic>blood-brain barrier</topic><topic>cell membranes</topic><topic>Docetaxel</topic><topic>Drug nanocrystals</topic><topic>drugs</topic><topic>erythrocytes</topic><topic>Glioma</topic><topic>ligands</topic><topic>nanocrystals</topic><topic>nanomedicine</topic><topic>Red blood cell membrane coating</topic><topic>therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Yuan</creatorcontrib><creatorcontrib>Xu, Qianzhu</creatorcontrib><creatorcontrib>Chai, Zhilan</creatorcontrib><creatorcontrib>Wu, Sunyi</creatorcontrib><creatorcontrib>Xu, Weixia</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Zhou, Jianfen</creatorcontrib><creatorcontrib>Luo, Zimiao</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Xie, Cao</creatorcontrib><creatorcontrib>Lu, Linwei</creatorcontrib><creatorcontrib>Lu, Weiyue</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Yuan</au><au>Xu, Qianzhu</au><au>Chai, Zhilan</au><au>Wu, Sunyi</au><au>Xu, Weixia</au><au>Wang, Jun</au><au>Zhou, Jianfen</au><au>Luo, Zimiao</au><au>Liu, Yu</au><au>Xie, Cao</au><au>Lu, Linwei</au><au>Lu, Weiyue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>All-stage targeted red blood cell membrane-coated docetaxel nanocrystals for glioma treatment</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>369</volume><spage>325</spage><epage>334</epage><pages>325-334</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><abstract>Challenges for glioma treatment with nanomedicines include physio-anatomical barriers (the blood-brain barrier and blood-brain tumor barrier), low drug loading capacity, and limited circulation time. Here, a red blood cell membrane-coated docetaxel drug nanocrystal (pV-RBCm-NC(DTX)), modified with pHA-VAP (pV) for all-stage targeting of glioma, was designed. The NC(DTX) core exhibited a high drug loading capacity but low in vivo stability, and the RBCm coating significantly enhanced the stability and prolonged in vivo circulation. Moreover, the Y-shaped targeting ligand pV was modified by a mild avidin-biotin interaction, which endowed RBCm-NC(DTX) with superior barrier-crossing ability and therapeutic efficacy. The integration of nanocrystal technology, cell membrane coating, and the avidin-biotin insertion method into this active targeting biomimetic formulation represents a promising drug delivery strategy for glioma.
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| source | Elsevier ScienceDirect Journals |
| subjects | All-stage targeted therapy biomimetics blood-brain barrier cell membranes Docetaxel Drug nanocrystals drugs erythrocytes Glioma ligands nanocrystals nanomedicine Red blood cell membrane coating therapeutics |
| title | All-stage targeted red blood cell membrane-coated docetaxel nanocrystals for glioma treatment |
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