Multixenobiotic defence mechanism in native and exotic freshwater snails as a biomarker for land uses-changes

Human activities such as agriculture and urbanization generate a large number of substances like personal care products, pharmaceutical compounds, and pesticides, which often reach aquatic environments and represent a threat to biodiversity. Many organisms have developed different evolutionary strat...

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Veröffentlicht in:Comparative biochemistry and physiology. Toxicology & pharmacology 2023-05, Vol.267, p.109580-109580, Article 109580
Hauptverfasser: Horak, Cristina Natalia, Miserendino, María Laura, Assef, Yanina Andrea
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container_title Comparative biochemistry and physiology. Toxicology & pharmacology
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creator Horak, Cristina Natalia
Miserendino, María Laura
Assef, Yanina Andrea
description Human activities such as agriculture and urbanization generate a large number of substances like personal care products, pharmaceutical compounds, and pesticides, which often reach aquatic environments and represent a threat to biodiversity. Many organisms have developed different evolutionary strategies to remove pervasive substances from their bodies, allowing them to persist even in polluted environments, and one of these is the multixenobiotic resistance (MXR) mechanism associated with the expression of membrane proteins like P-glycoprotein (P-gp). Numerous chemical compounds with diverse functions and structures can modulate this mechanism, which can be employed as a pollution biomarker. We examined the MXR activity in two species of snails that inhabit Patagonian freshwaters. Functional assay measurements of MXR were conducted on the native Chilina dombeiana and the exotic Physella acuta in stream reaches affected by anthropogenic impacts. Results indicated that at agricultural sites, C. dombeiana snails had a more active MXR system than organisms sampled at reference and moderately disturbed urban sites, whereas P. acuta snails from agricultural and highly disturbed urban sites showed better detoxifying activity than organisms from reference sites. Only in exotic snails, part of this activity was due to the action of P-gp. The most important environmental variables explaining MXR activity were ammonium, nitrate and nitrite, phosphates, and electrical conductivity. These results show the promise of measuring MXR activity in native and exotic snails, as a biomarker in the environmental monitoring of Patagonian freshwaters. [Display omitted] •MXR activity and P-gp action assessed in native snail Chilina dombeiana and exotic snail Physella acuta.•C. dombeiana and P. acuta from anthropogenic sites showed higher MXR activity than from reference.•The detoxification activity has a differential response by species in relation to land use.•Native species have more restricted ecological requirements appears important for integrated biomonitoring programs.
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source MEDLINE; Elsevier ScienceDirect Journals
subjects ammonium
biodiversity
Biomarkers
Biomonitoring
Chilina
electrical conductivity
Fresh Water
freshwater
Freshwater toxicology
Humans
Membrane Proteins
MXR
nitrates
nitrites
P-glycoproteins
Patagonia
Physella acuta
physiology
pollution
species
streams
urbanization
Water Pollutants, Chemical - analysis
Water Pollutants, Chemical - toxicity
Xenobiotics - metabolism
title Multixenobiotic defence mechanism in native and exotic freshwater snails as a biomarker for land uses-changes
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