Multixenobiotic defence mechanism in native and exotic freshwater snails as a biomarker for land uses-changes
Human activities such as agriculture and urbanization generate a large number of substances like personal care products, pharmaceutical compounds, and pesticides, which often reach aquatic environments and represent a threat to biodiversity. Many organisms have developed different evolutionary strat...
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container_title | Comparative biochemistry and physiology. Toxicology & pharmacology |
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creator | Horak, Cristina Natalia Miserendino, María Laura Assef, Yanina Andrea |
description | Human activities such as agriculture and urbanization generate a large number of substances like personal care products, pharmaceutical compounds, and pesticides, which often reach aquatic environments and represent a threat to biodiversity. Many organisms have developed different evolutionary strategies to remove pervasive substances from their bodies, allowing them to persist even in polluted environments, and one of these is the multixenobiotic resistance (MXR) mechanism associated with the expression of membrane proteins like P-glycoprotein (P-gp). Numerous chemical compounds with diverse functions and structures can modulate this mechanism, which can be employed as a pollution biomarker. We examined the MXR activity in two species of snails that inhabit Patagonian freshwaters. Functional assay measurements of MXR were conducted on the native Chilina dombeiana and the exotic Physella acuta in stream reaches affected by anthropogenic impacts. Results indicated that at agricultural sites, C. dombeiana snails had a more active MXR system than organisms sampled at reference and moderately disturbed urban sites, whereas P. acuta snails from agricultural and highly disturbed urban sites showed better detoxifying activity than organisms from reference sites. Only in exotic snails, part of this activity was due to the action of P-gp. The most important environmental variables explaining MXR activity were ammonium, nitrate and nitrite, phosphates, and electrical conductivity. These results show the promise of measuring MXR activity in native and exotic snails, as a biomarker in the environmental monitoring of Patagonian freshwaters.
[Display omitted]
•MXR activity and P-gp action assessed in native snail Chilina dombeiana and exotic snail Physella acuta.•C. dombeiana and P. acuta from anthropogenic sites showed higher MXR activity than from reference.•The detoxification activity has a differential response by species in relation to land use.•Native species have more restricted ecological requirements appears important for integrated biomonitoring programs. |
doi_str_mv | 10.1016/j.cbpc.2023.109580 |
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[Display omitted]
•MXR activity and P-gp action assessed in native snail Chilina dombeiana and exotic snail Physella acuta.•C. dombeiana and P. acuta from anthropogenic sites showed higher MXR activity than from reference.•The detoxification activity has a differential response by species in relation to land use.•Native species have more restricted ecological requirements appears important for integrated biomonitoring programs.</description><identifier>ISSN: 1532-0456</identifier><identifier>EISSN: 1878-1659</identifier><identifier>DOI: 10.1016/j.cbpc.2023.109580</identifier><identifier>PMID: 36822297</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ammonium ; biodiversity ; Biomarkers ; Biomonitoring ; Chilina ; electrical conductivity ; Fresh Water ; freshwater ; Freshwater toxicology ; Humans ; Membrane Proteins ; MXR ; nitrates ; nitrites ; P-glycoproteins ; Patagonia ; Physella acuta ; physiology ; pollution ; species ; streams ; urbanization ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - toxicity ; Xenobiotics - metabolism</subject><ispartof>Comparative biochemistry and physiology. Toxicology & pharmacology, 2023-05, Vol.267, p.109580-109580, Article 109580</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c340t-42d7439ad7aa37c9a5d63b64ba35f79ae54ce2b5300d0d612d129478c45cd6bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1532045623000352$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36822297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horak, Cristina Natalia</creatorcontrib><creatorcontrib>Miserendino, María Laura</creatorcontrib><creatorcontrib>Assef, Yanina Andrea</creatorcontrib><title>Multixenobiotic defence mechanism in native and exotic freshwater snails as a biomarker for land uses-changes</title><title>Comparative biochemistry and physiology. Toxicology & pharmacology</title><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><description>Human activities such as agriculture and urbanization generate a large number of substances like personal care products, pharmaceutical compounds, and pesticides, which often reach aquatic environments and represent a threat to biodiversity. Many organisms have developed different evolutionary strategies to remove pervasive substances from their bodies, allowing them to persist even in polluted environments, and one of these is the multixenobiotic resistance (MXR) mechanism associated with the expression of membrane proteins like P-glycoprotein (P-gp). Numerous chemical compounds with diverse functions and structures can modulate this mechanism, which can be employed as a pollution biomarker. We examined the MXR activity in two species of snails that inhabit Patagonian freshwaters. Functional assay measurements of MXR were conducted on the native Chilina dombeiana and the exotic Physella acuta in stream reaches affected by anthropogenic impacts. Results indicated that at agricultural sites, C. dombeiana snails had a more active MXR system than organisms sampled at reference and moderately disturbed urban sites, whereas P. acuta snails from agricultural and highly disturbed urban sites showed better detoxifying activity than organisms from reference sites. Only in exotic snails, part of this activity was due to the action of P-gp. The most important environmental variables explaining MXR activity were ammonium, nitrate and nitrite, phosphates, and electrical conductivity. These results show the promise of measuring MXR activity in native and exotic snails, as a biomarker in the environmental monitoring of Patagonian freshwaters.
[Display omitted]
•MXR activity and P-gp action assessed in native snail Chilina dombeiana and exotic snail Physella acuta.•C. dombeiana and P. acuta from anthropogenic sites showed higher MXR activity than from reference.•The detoxification activity has a differential response by species in relation to land use.•Native species have more restricted ecological requirements appears important for integrated biomonitoring programs.</description><subject>ammonium</subject><subject>biodiversity</subject><subject>Biomarkers</subject><subject>Biomonitoring</subject><subject>Chilina</subject><subject>electrical conductivity</subject><subject>Fresh Water</subject><subject>freshwater</subject><subject>Freshwater toxicology</subject><subject>Humans</subject><subject>Membrane Proteins</subject><subject>MXR</subject><subject>nitrates</subject><subject>nitrites</subject><subject>P-glycoproteins</subject><subject>Patagonia</subject><subject>Physella acuta</subject><subject>physiology</subject><subject>pollution</subject><subject>species</subject><subject>streams</subject><subject>urbanization</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Xenobiotics - metabolism</subject><issn>1532-0456</issn><issn>1878-1659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3DAURi1UBNOBP9BF5WU3mfrtRGJTIaBIg9jA2nLsG_A0j8FOePx7HGbaZZEs2bo699P1PQh9o2RFCVU_NytXb92KEcZzoZIlOUALWuqyoEpWX_JbclYQIdUx-prShhAiBVVH6JirkjFW6QXqbqZ2DK_QD3UYxuCwhwZ6B7gD92j7kDocetzbMTwDtr3H8PqBNRHS44sdIeLU29AmbPPBOaSz8U-uNkPE7dwwJUjFnPUA6QQdNrZNcLq_l-j-8uLu_Hexvr26Pv-1LhwXZCwE81rwynptLdeustIrXitRWy4bXVmQwgGrJSfEE68o85RVQpdOSOdVXfMl-rHL3cbhaYI0mi4kB20eCIYpGZ43o5WWUnyKMl0SoktOVUbZDnVxSClCY7Yx5O--GUrMbMRszGzEzEbMzkhu-r7Pn-oO_L-WvwoycLYDIC_kOUA0yYVZgQ8R3Gj8EP6X_w7dLp1J</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Horak, Cristina Natalia</creator><creator>Miserendino, María Laura</creator><creator>Assef, Yanina Andrea</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202305</creationdate><title>Multixenobiotic defence mechanism in native and exotic freshwater snails as a biomarker for land uses-changes</title><author>Horak, Cristina Natalia ; Miserendino, María Laura ; Assef, Yanina Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-42d7439ad7aa37c9a5d63b64ba35f79ae54ce2b5300d0d612d129478c45cd6bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ammonium</topic><topic>biodiversity</topic><topic>Biomarkers</topic><topic>Biomonitoring</topic><topic>Chilina</topic><topic>electrical conductivity</topic><topic>Fresh Water</topic><topic>freshwater</topic><topic>Freshwater toxicology</topic><topic>Humans</topic><topic>Membrane Proteins</topic><topic>MXR</topic><topic>nitrates</topic><topic>nitrites</topic><topic>P-glycoproteins</topic><topic>Patagonia</topic><topic>Physella acuta</topic><topic>physiology</topic><topic>pollution</topic><topic>species</topic><topic>streams</topic><topic>urbanization</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Xenobiotics - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horak, Cristina Natalia</creatorcontrib><creatorcontrib>Miserendino, María Laura</creatorcontrib><creatorcontrib>Assef, Yanina Andrea</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Comparative biochemistry and physiology. Toxicology & pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horak, Cristina Natalia</au><au>Miserendino, María Laura</au><au>Assef, Yanina Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multixenobiotic defence mechanism in native and exotic freshwater snails as a biomarker for land uses-changes</atitle><jtitle>Comparative biochemistry and physiology. Toxicology & pharmacology</jtitle><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><date>2023-05</date><risdate>2023</risdate><volume>267</volume><spage>109580</spage><epage>109580</epage><pages>109580-109580</pages><artnum>109580</artnum><issn>1532-0456</issn><eissn>1878-1659</eissn><abstract>Human activities such as agriculture and urbanization generate a large number of substances like personal care products, pharmaceutical compounds, and pesticides, which often reach aquatic environments and represent a threat to biodiversity. Many organisms have developed different evolutionary strategies to remove pervasive substances from their bodies, allowing them to persist even in polluted environments, and one of these is the multixenobiotic resistance (MXR) mechanism associated with the expression of membrane proteins like P-glycoprotein (P-gp). Numerous chemical compounds with diverse functions and structures can modulate this mechanism, which can be employed as a pollution biomarker. We examined the MXR activity in two species of snails that inhabit Patagonian freshwaters. Functional assay measurements of MXR were conducted on the native Chilina dombeiana and the exotic Physella acuta in stream reaches affected by anthropogenic impacts. Results indicated that at agricultural sites, C. dombeiana snails had a more active MXR system than organisms sampled at reference and moderately disturbed urban sites, whereas P. acuta snails from agricultural and highly disturbed urban sites showed better detoxifying activity than organisms from reference sites. Only in exotic snails, part of this activity was due to the action of P-gp. The most important environmental variables explaining MXR activity were ammonium, nitrate and nitrite, phosphates, and electrical conductivity. These results show the promise of measuring MXR activity in native and exotic snails, as a biomarker in the environmental monitoring of Patagonian freshwaters.
[Display omitted]
•MXR activity and P-gp action assessed in native snail Chilina dombeiana and exotic snail Physella acuta.•C. dombeiana and P. acuta from anthropogenic sites showed higher MXR activity than from reference.•The detoxification activity has a differential response by species in relation to land use.•Native species have more restricted ecological requirements appears important for integrated biomonitoring programs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36822297</pmid><doi>10.1016/j.cbpc.2023.109580</doi><tpages>1</tpages></addata></record> |
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subjects | ammonium biodiversity Biomarkers Biomonitoring Chilina electrical conductivity Fresh Water freshwater Freshwater toxicology Humans Membrane Proteins MXR nitrates nitrites P-glycoproteins Patagonia Physella acuta physiology pollution species streams urbanization Water Pollutants, Chemical - analysis Water Pollutants, Chemical - toxicity Xenobiotics - metabolism |
title | Multixenobiotic defence mechanism in native and exotic freshwater snails as a biomarker for land uses-changes |
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