Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes

Novel cytochrome P450 3A5 (CYP3A5) cDNA in tree shrews (which are non-rodent primate-like species) and pig CYP3A227 cDNA were identified, along with known pig CYP3A22, CYP3A29, and CYP3A46 cDNAs. All five cDNAs contained open reading frames encoding a polypeptide of 503 amino acids that shared high...

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Veröffentlicht in:	Comparative biochemistry and physiology. Toxicology & pharmacology 2023-05, Vol.267, p.109579-109579, Article 109579
Hauptverfasser:	Uno, Yasuhiro, Jikuya, Shiori, Noda, Yutaro, Oguchi, Asuka, Murayama, Norie, Kawaguchi, Hiroaki, Tsukiyama-Kohara, Kyoko, Yamazaki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CYP3A227 CYP3A5 cytochrome P-450 Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism DNA, Complementary - genetics Escherichia coli genomics Humans jejunum liver Midazolam multigene family Phylogeny physiology polypeptides Rats RNA, Messenger - genetics Scandentia sequence analysis species Swine trees Tupaia Tupaia - genetics Tupaia - metabolism Tupaiidae - genetics Tupaiidae - metabolism
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