Therapeutic potential of aquatic Stevia extract in alleviating endoplasmic reticulum stress and liver damage in streptozotocin-induced diabetic rats

Background Misfolded proteins accumulate in the liver due to endoplasmic reticulum stress (ERS) caused by high blood glucose levels in diabetes. This triggers the unfolded protein response (UPR), which if persistently activated, results in cellular dysfunction. Chronic ER stress increases inflammati...

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Veröffentlicht in:	Molecular biology reports 2024-12, Vol.51 (1), p.993-993, Article 993
Hauptverfasser:	Saadi, Hediye Fahandezh, Zamani, Mozhdeh, Koohpeyma, Farhad, Raeisi, Alireza, Amirahmadi, Zahra, Rezaei, Narges, Joolidehpoor, Zahra, Shams, Mesbah, Dastghaib, Sanaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Animals Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Aquatic plants Biomedical and Life Sciences blood glucose Blood Glucose - drug effects Blood Glucose - metabolism Blood levels Body weight Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Endoplasmic reticulum endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Gene expression Histology Hyperglycemia Hypoglycemic Agents - pharmacology Inflammation Insulin resistance intraperitoneal injection Life Sciences Liver Liver - drug effects Liver - metabolism Liver - pathology Male Medicinal plants Metformin Morphology Original Article Oxidative stress Oxidative Stress - drug effects Plant extracts Plant Extracts - pharmacology Protein folding Rats Stevia Stevia - chemistry Streptozocin streptozotocin traditional medicine unfolded protein response Unfolded Protein Response - drug effects
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