l‑Theanine Alleviates Ulcerative Colitis by Regulating Colon Immunity via the Gut Microbiota in an MHC-II-Dependent Manner

Alterations to the gut microbiota are associated with ulcerative colitis (UC), whereas restoration of normobiosis can effectively alleviate UC. l-Theanine has been shown to reshape the gut microbiota and regulate gut immunity. To investigate the mechanisms by which l-theanine alleviates UC, we used...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2024-09, Vol.72 (36), p.19852-19868
Hauptverfasser:	Xu, Wei, Liu, Ao-Xiang, Liu, Ke-Hong, Zhang, Sheng, Gong, Zhi-Hua, Xiao, Wen-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria - classification Bacteria - drug effects Bacteria - genetics Bacteria - immunology Bacteria - isolation & purification bile acids Bioactive Constituents, Metabolites, and Functions Colitis, Ulcerative - drug therapy Colitis, Ulcerative - immunology Colitis, Ulcerative - microbiology colon Colon - drug effects Colon - immunology Colon - microbiology Feces - microbiology flow cytometry food chemistry Gastrointestinal Microbiome - drug effects Glutamates - administration & dosage Glutamates - pharmacology Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Humans inflammation innate immunity intestinal microorganisms macrophages Macrophages - drug effects Macrophages - immunology Male Mice Mice, Inbred C57BL monocytes short chain fatty acids T-Lymphocytes - drug effects T-Lymphocytes - immunology tryptophan ulcerative colitis
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