Cu-Catalyzed Three-Component Alkene Carboamination: Mechanistic Insights and Rational Design to Overcome Limitations

Herein, we report mechanistic investigations into the Cu-catalyzed three-component carboamination of alkenes with α-halo carbonyls and aryl amines via an oxocarbenium intermediate. Monitoring the reaction reveals the formation of transient atom transfer radical addition (ATRA) intermediates with bot...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-09, Vol.146 (36), p.25176-25189
Hauptverfasser:	Ho, Tam D., Lee, Byung Joo, Buchanan, Travis L., Heikes, Micah E., Steinert, Ryan M., Milem, E. Grace, Goralski, Sean T., Wang, Ya-Nong, Lee, SangHyun, Lynch, Vincent M., Rose, Michael J., Mitchell-Koch, Katie R., Hull, Kami L.
Format:	Artikel
Sprache:	eng
Schlagworte:	alkenes aromatic hydrocarbons catalysts density functional theory Lewis bases regioselectivity
Online-Zugang:	Volltext
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