Altered S‐AdenosylMethionine availability impacts dNTP pools in Saccharomyces cerevisiae

Saccharomyces cerevisiae has long been used as a model organism to study genome instability. The SAM1 and SAM2 genes encode AdoMet synthetases, which generate S‐AdenosylMethionine (AdoMet) from Methionine (Met) and ATP. Previous work from our group has shown that deletions of the SAM1 and SAM2 genes...

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Veröffentlicht in:	Yeast (Chichester, England) England), 2024-08, Vol.41 (8), p.513-524
Hauptverfasser:	Panmanee, Warunya, Tran, Men T. H., Seye, Serigne N., Strome, Erin D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine AdoMet synthetases cell growth Deoxyribonucleotides Deoxyribonucleotides - metabolism Detoxification DNA damage DNA methylation Folic acid genetic instability Genomes Genomic Instability Glutathione Hydroxyurea ligases Lipid metabolism metabolism Methionine Methionine - metabolism methyl cycle methylation Nucleotides - metabolism polyamines Reactive oxygen species S-adenosylmethionine S-Adenosylmethionine - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism S‐adenosylmethionine (AdoMet) Yeast yeast genetics yeasts
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