Development of a baculoviral CRISPR/Cas9 vector system for beta-2-microglobulin knockout in human pluripotent stem cells

Derivation of hypoimmunogenic human cells from genetically manipulated pluripotent stem cells holds great promise for future transplantation medicine and adoptive immunotherapy. Disruption of beta-2-microglobulin ( B2M ) in pluripotent stem cells followed by differentiation into specialized cell typ...

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Veröffentlicht in:	Molecular genetics and genomics : MGG 2024-12, Vol.299 (1), p.74-74, Article 74
Hauptverfasser:	Xiang, Zaiying, Ye, Qiaoyuan, Zhao, Zihan, Wang, Naian, Li, Jinrong, Zou, Minghai, Lau, Cia-Hin, Zhu, Haibao, Wang, Shu, Ding, Yuanlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive immunotherapy Animal Genetics and Genomics Animals B2m gene Baculoviridae Baculoviridae - genetics beta 2-Microglobulin - genetics Biochemistry Biomedical and Life Sciences Cell differentiation Cell Differentiation - genetics Cell surface Cell therapy class coculture CRISPR CRISPR-Cas Systems Embryo cells Embryogenesis Enzyme-linked immunosorbent assay Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gene Editing - methods Gene Knockout Techniques - methods gene targeting genes Genetic engineering Genetic Vectors - genetics Genome editing genomics Histocompatibility antigen HLA HLA antigens Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism Human Genetics Humans Immunotherapy Leukocytes (mononuclear) Life Sciences loci medicine Mice Microbial Genetics and Genomics Original Article Peripheral blood mononuclear cells Plant Genetics and Genomics Pluripotency Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Stem cells β2 Microglobulin
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