Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis
The isolation, structure determination, and biological evaluation of constituents from the organic extract of Turraea delphinensis Wahlert (Meliaceae) resulted in the isolation of 51 secondary metabolites, including 14 new terpenoids (six cycloartanes, four tirucallanes/euphanes, three limonoids, an...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2024-07, Vol.87 (7), p.1763-1777 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 87 |
| creator | Kouno, Hayato Amuti, Saidanxia Saito, Yohei Fukuyoshi, Shuichi Miyake, Katsunori Goto, Masuo Newman, David J. O’Keefe, Barry R. Lee, Kuo-Hsiung Nakagawa-Goto, Kyoko |
| description | The isolation, structure determination, and biological evaluation of constituents from the organic extract of Turraea delphinensis Wahlert (Meliaceae) resulted in the isolation of 51 secondary metabolites, including 14 new terpenoids (six cycloartanes, four tirucallanes/euphanes, three limonoids, and a 7-keto sterol). Among the new compounds, 1 is the first triterpenoid with a trioxaspiro[4.4]nonane side chain, while 11–13 are the first 17-γ-lactone tetranortriterpenoids with four oxygenated functional groups at C-1, -3, -6, and -7. The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a vinblastine-resistant cell line. |
| doi_str_mv | 10.1021/acs.jnatprod.4c00313 |
| format | Article |
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The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a vinblastine-resistant cell line.</description><subject>biological assessment</subject><subject>cell lines</subject><subject>limonoids</subject><subject>Meliaceae</subject><subject>neoplasm cells</subject><subject>secondary metabolites</subject><subject>sterols</subject><subject>tropical plants</subject><issn>0163-3864</issn><issn>1520-6025</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EotuPf4CQjxzI1t9JjqtVgUqV4LCco6kz1rrK2sF2KrW_HtPdcoTTSKPnnfH4IeQDZ2vOBL8Gm9cPAcqc4rhWljHJ5Ruy4lqwxjCh35IV40Y2sjPqjJzn_MAqw3r9npzJrm-ZZmpFHm9znKD4GD7T7R4S2ILJP586EEa6CcXXHZN3mGr7EenG1uLLE42O7jDNGKIfM3UpHmjZI92lOHsLE_0xQSh0t6QECHTEad77gCH7fEneOZgyXp3qBfn55Wa3_dbcff96u93cNSAMK43pOYy8Bad6p0Gr0QkltNNOKqNsZ5x1qLnsoO1GycBwFNiDY8gt03DfyQvy6Ti3XvBrwVyGg88Wp_owjEseJNeyVaJV5v8oa40SQmlZUXVEbYo5J3TDnPwB0tPA2fBHzlDlDK9yhpOcGvt42rDcH3D8G3q1UQF2BF7icUmh_s2_Z_4GvO-g2A</recordid><startdate>20240726</startdate><enddate>20240726</enddate><creator>Kouno, Hayato</creator><creator>Amuti, Saidanxia</creator><creator>Saito, Yohei</creator><creator>Fukuyoshi, Shuichi</creator><creator>Miyake, Katsunori</creator><creator>Goto, Masuo</creator><creator>Newman, David J.</creator><creator>O’Keefe, Barry R.</creator><creator>Lee, Kuo-Hsiung</creator><creator>Nakagawa-Goto, Kyoko</creator><general>American Chemical Society and American Society of Pharmacognosy</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-9659-1460</orcidid><orcidid>https://orcid.org/0000-0003-0772-4856</orcidid><orcidid>https://orcid.org/0000-0002-4959-2428</orcidid><orcidid>https://orcid.org/0000-0002-6562-0070</orcidid><orcidid>https://orcid.org/0000-0002-1642-6538</orcidid></search><sort><creationdate>20240726</creationdate><title>Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis</title><author>Kouno, Hayato ; Amuti, Saidanxia ; Saito, Yohei ; Fukuyoshi, Shuichi ; Miyake, Katsunori ; Goto, Masuo ; Newman, David J. ; O’Keefe, Barry R. ; Lee, Kuo-Hsiung ; Nakagawa-Goto, Kyoko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a260t-691ad17af49f5a54df2425f5f3464c86fcfe5138a78d30a61e2e9af0e1c05ab83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>biological assessment</topic><topic>cell lines</topic><topic>limonoids</topic><topic>Meliaceae</topic><topic>neoplasm cells</topic><topic>secondary metabolites</topic><topic>sterols</topic><topic>tropical plants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kouno, Hayato</creatorcontrib><creatorcontrib>Amuti, Saidanxia</creatorcontrib><creatorcontrib>Saito, Yohei</creatorcontrib><creatorcontrib>Fukuyoshi, Shuichi</creatorcontrib><creatorcontrib>Miyake, Katsunori</creatorcontrib><creatorcontrib>Goto, Masuo</creatorcontrib><creatorcontrib>Newman, David J.</creatorcontrib><creatorcontrib>O’Keefe, Barry R.</creatorcontrib><creatorcontrib>Lee, Kuo-Hsiung</creatorcontrib><creatorcontrib>Nakagawa-Goto, Kyoko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kouno, Hayato</au><au>Amuti, Saidanxia</au><au>Saito, Yohei</au><au>Fukuyoshi, Shuichi</au><au>Miyake, Katsunori</au><au>Goto, Masuo</au><au>Newman, David J.</au><au>O’Keefe, Barry R.</au><au>Lee, Kuo-Hsiung</au><au>Nakagawa-Goto, Kyoko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. 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| subjects | biological assessment cell lines limonoids Meliaceae neoplasm cells secondary metabolites sterols tropical plants |
| title | Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis |
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