Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function

INTS11 and CPSF73 are metal-dependent endonucleases for Integrator and pre-mRNA 3′-end processing, respectively. Here, we show that the INTS11 binding partner BRAT1/CG7044, a factor important for neuronal fitness, stabilizes INTS11 in the cytoplasm and is required for Integrator function in the nucl...

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Veröffentlicht in:	Molecular cell 2024-08, Vol.84 (15), p.2900-2917.e10
Hauptverfasser:	Lin, Min-Han, Jensen, Madeline K., Elrod, Nathan D., Chu, Hsu-Feng, Haseley, MaryClaire, Beam, Alissa C., Huang, Kai-Lieh, Chiang, Wesley, Russell, William K., Williams, Kelsey, Pröschel, Christoph, Wagner, Eric J., Tong, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	3′-end processing active sites Animals Catalytic Domain Cell Nucleus - metabolism chaperone Cleavage And Polyadenylation Specificity Factor - genetics Cleavage And Polyadenylation Specificity Factor - metabolism cysteine cytoplasm Cytoplasm - metabolism Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism endonuclease Endonucleases - genetics Endonucleases - metabolism HEK293 Cells Humans Integrator Neurogenesis - genetics neurons organoids Protein Binding transcription termination transcriptomics Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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