Effect of RNAi-Mediated Survivin and Hypoxia-Inducible Factor 1α Gene Silencing on Proliferation, Invasion, Migration and Apoptosis of Gastric Cancer BGC-823 Cells

In order to investigate the effects of RNAi-mediated survivin and hypoxia-inducible factor 1α (HIF-1α) gene silencing on the proliferation and apoptosis of gastric cancer BGC-823 cells, small interfering RNAs (siRNAs) targeting survivin and HIF-1α mRNAs, respectively, as well as scrambled siRNAs (SC...

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Veröffentlicht in:	Molecular biotechnology 2024-08, Vol.66 (8), p.1872-1882
Hauptverfasser:	Li, Yupeng, Liu, Yongchao, Chang, Mingzhu, Mu, Runhong, Zhu, Jianyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral agents Apoptosis Apoptosis - genetics Biochemistry Biological Techniques Biotechnology Cancer therapies Cell Biology Cell Line, Tumor Cell migration Cell Movement Cell proliferation Cell Proliferation - genetics Chemistry Chemistry and Materials Science Gastric cancer Gene disruption Gene expression Gene Expression Regulation, Neoplastic Gene Silencing gene targeting genes Highly active antiretroviral therapy Human Genetics Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a neoplasm cells Neoplasm Invasiveness - genetics Original Paper pro-apoptotic proteins Protein Science RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-mediated interference siRNA stomach neoplasms Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Survival Survivin Survivin - genetics Survivin - metabolism therapeutics Transfection Western blotting
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