Laggera alata Attenuates Inflammatory Response by Regulating Macrophage Polarization in Rheumatoid Arthritis Mice
Rheumatoid arthritis (RA) is a type of joint injury, which can induce the activation of inflammatory factors and polarization of tissue macrophages. Total phenolics from Laggera alata (TPLA) has been reported to exhibit anti-inflammatory effect in various diseases. However, its specific function in...
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| Veröffentlicht in: | Molecular biotechnology 2024-08, Vol.66 (8), p.1934-1941 |
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| creator | Wei, Jiangcun Tang, Yunli Qin, Suhong Ma, Xiumei Zhong, Wen Yang, Peng Deng, Qingmei Ma, Jiabao |
| description | Rheumatoid arthritis (RA) is a type of joint injury, which can induce the activation of inflammatory factors and polarization of tissue macrophages. Total phenolics from
Laggera alata
(TPLA) has been reported to exhibit anti-inflammatory effect in various diseases. However, its specific function in RA is still unknown. Here, the protective properties of TPLA were studied in collagen-induced arthritis (CIA)-induced RA mice. RA mouse model was established through the CIA induction. Arthritis score, hind paw thickness, and the body weight of the RA mice were evaluated in each group. H&E staining was conducted in hind paw and joint tissues for histopathological staining. The distal femur was analyzed by microCT, and bone loss-related indicators were assessed. The expression of macrophage polarization markers was detected by immunofluorescence staining in RA mice. The serum levels of inflammatory markers were determined by enzyme-linked immunosorbent assay (ELISA). TPLA reduced the CIA-induced arthritis score and hind paw thickness in mice. The body weight of the CIA mouse was significantly increased by TPLA treatment. TPLA improved the CIA-induced histopathological changes in the hind paw and joint tissues from the mice. TPLA inhibited the bone loss and alleviated bone destruction in CIA mouse model. TPLA altered the macrophage phenotype from M1 macrophages into M2 in CIA mice. TPLA suppressed the levels of inflammatory markers both in the serum and joint tissues of the CIA mice. TPLA mitigated RA development by suppressing inflammatory reaction through the inhibition of M1 microphage polarization. |
| doi_str_mv | 10.1007/s12033-023-00808-w |
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Laggera alata
(TPLA) has been reported to exhibit anti-inflammatory effect in various diseases. However, its specific function in RA is still unknown. Here, the protective properties of TPLA were studied in collagen-induced arthritis (CIA)-induced RA mice. RA mouse model was established through the CIA induction. Arthritis score, hind paw thickness, and the body weight of the RA mice were evaluated in each group. H&E staining was conducted in hind paw and joint tissues for histopathological staining. The distal femur was analyzed by microCT, and bone loss-related indicators were assessed. The expression of macrophage polarization markers was detected by immunofluorescence staining in RA mice. The serum levels of inflammatory markers were determined by enzyme-linked immunosorbent assay (ELISA). TPLA reduced the CIA-induced arthritis score and hind paw thickness in mice. The body weight of the CIA mouse was significantly increased by TPLA treatment. TPLA improved the CIA-induced histopathological changes in the hind paw and joint tissues from the mice. TPLA inhibited the bone loss and alleviated bone destruction in CIA mouse model. TPLA altered the macrophage phenotype from M1 macrophages into M2 in CIA mice. TPLA suppressed the levels of inflammatory markers both in the serum and joint tissues of the CIA mice. TPLA mitigated RA development by suppressing inflammatory reaction through the inhibition of M1 microphage polarization.</description><identifier>ISSN: 1073-6085</identifier><identifier>ISSN: 1559-0305</identifier><identifier>EISSN: 1559-0305</identifier><identifier>DOI: 10.1007/s12033-023-00808-w</identifier><identifier>PMID: 37493934</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents - pharmacology ; Arthritis ; Arthritis, Experimental - pathology ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Autoimmune diseases ; Biochemistry ; Biological Techniques ; Biotechnology ; blood serum ; Body weight ; Bone loss ; bone resorption ; Cell activation ; Cell Biology ; Chemistry ; Chemistry and Materials Science ; Computed tomography ; Disease Models, Animal ; Enzyme-linked immunosorbent assay ; Femur ; fluorescent antibody technique ; histopathology ; Human Genetics ; Immunofluorescence ; inflammation ; Inflammation - pathology ; Inflammatory response ; Joints (anatomy) ; Laggera ; Laggera alata ; Macrophages ; Macrophages - immunology ; Male ; Mice ; Mice, Inbred DBA ; micro-computed tomography ; Original Paper ; phenolic compounds ; Phenols ; phenotype ; Phenotypes ; Plant Extracts - pharmacology ; Polarization ; Protein Science ; Rheumatoid arthritis ; Serum levels ; Staining ; Thickness</subject><ispartof>Molecular biotechnology, 2024-08, Vol.66 (8), p.1934-1941</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-eb03431466c542db8196a781df2eaff9a457437a3cd803b148f140a8be6a99ac3</cites><orcidid>0000-0002-5441-7608</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12033-023-00808-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12033-023-00808-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37493934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Jiangcun</creatorcontrib><creatorcontrib>Tang, Yunli</creatorcontrib><creatorcontrib>Qin, Suhong</creatorcontrib><creatorcontrib>Ma, Xiumei</creatorcontrib><creatorcontrib>Zhong, Wen</creatorcontrib><creatorcontrib>Yang, Peng</creatorcontrib><creatorcontrib>Deng, Qingmei</creatorcontrib><creatorcontrib>Ma, Jiabao</creatorcontrib><title>Laggera alata Attenuates Inflammatory Response by Regulating Macrophage Polarization in Rheumatoid Arthritis Mice</title><title>Molecular biotechnology</title><addtitle>Mol Biotechnol</addtitle><addtitle>Mol Biotechnol</addtitle><description>Rheumatoid arthritis (RA) is a type of joint injury, which can induce the activation of inflammatory factors and polarization of tissue macrophages. Total phenolics from
Laggera alata
(TPLA) has been reported to exhibit anti-inflammatory effect in various diseases. However, its specific function in RA is still unknown. Here, the protective properties of TPLA were studied in collagen-induced arthritis (CIA)-induced RA mice. RA mouse model was established through the CIA induction. Arthritis score, hind paw thickness, and the body weight of the RA mice were evaluated in each group. H&E staining was conducted in hind paw and joint tissues for histopathological staining. The distal femur was analyzed by microCT, and bone loss-related indicators were assessed. The expression of macrophage polarization markers was detected by immunofluorescence staining in RA mice. The serum levels of inflammatory markers were determined by enzyme-linked immunosorbent assay (ELISA). TPLA reduced the CIA-induced arthritis score and hind paw thickness in mice. The body weight of the CIA mouse was significantly increased by TPLA treatment. TPLA improved the CIA-induced histopathological changes in the hind paw and joint tissues from the mice. TPLA inhibited the bone loss and alleviated bone destruction in CIA mouse model. TPLA altered the macrophage phenotype from M1 macrophages into M2 in CIA mice. TPLA suppressed the levels of inflammatory markers both in the serum and joint tissues of the CIA mice. TPLA mitigated RA development by suppressing inflammatory reaction through the inhibition of M1 microphage polarization.</description><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Arthritis</subject><subject>Arthritis, Experimental - pathology</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Autoimmune diseases</subject><subject>Biochemistry</subject><subject>Biological Techniques</subject><subject>Biotechnology</subject><subject>blood serum</subject><subject>Body weight</subject><subject>Bone loss</subject><subject>bone resorption</subject><subject>Cell activation</subject><subject>Cell Biology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Computed tomography</subject><subject>Disease Models, Animal</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Femur</subject><subject>fluorescent antibody technique</subject><subject>histopathology</subject><subject>Human Genetics</subject><subject>Immunofluorescence</subject><subject>inflammation</subject><subject>Inflammation - pathology</subject><subject>Inflammatory response</subject><subject>Joints (anatomy)</subject><subject>Laggera</subject><subject>Laggera alata</subject><subject>Macrophages</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>micro-computed tomography</subject><subject>Original Paper</subject><subject>phenolic compounds</subject><subject>Phenols</subject><subject>phenotype</subject><subject>Phenotypes</subject><subject>Plant Extracts - pharmacology</subject><subject>Polarization</subject><subject>Protein Science</subject><subject>Rheumatoid arthritis</subject><subject>Serum levels</subject><subject>Staining</subject><subject>Thickness</subject><issn>1073-6085</issn><issn>1559-0305</issn><issn>1559-0305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEUxydGY2v1C3gwJF68jAIPBjhuGrVNttE0eiZvZphZmhlmC0ya-ullu1UTD3ogvMDv_V_gV1WvGX3PKFUfEuMUoKa8LKqpru-eVKdMSlNToPJpqamCuqFanlQvUrqhlDMp4Hl1AkoYMCBOq9stjqOLSHDCjGSTswsrZpfIZRgmnGfMS7wn1y7tl5AcaQ_1uBbYh5FcYReX_Q5HR74uE0b_o5wvgfhArnduPTT7nmxi3kWffSJXvnMvq2cDTsm9etzPqu-fPn47v6i3Xz5fnm-2dQfS5Nq1FAQw0TSdFLxvNTMNKs36gTscBoNCKgEKoes1hZYJPTBBUbeuQWOwg7Pq3TF3H5fb1aVsZ586N00Y3LImC0yCAhDK_BflWnAhOReioG__Qm-WNYbyEAtUC6NUUVEofqTK96QU3WD30c8Y7y2j9uDOHt3Z4s4-uLN3penNY_Tazq7_3fJLVgHgCKRyFYq1P7P_EfsTeC2lVg</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Wei, Jiangcun</creator><creator>Tang, Yunli</creator><creator>Qin, Suhong</creator><creator>Ma, Xiumei</creator><creator>Zhong, Wen</creator><creator>Yang, Peng</creator><creator>Deng, Qingmei</creator><creator>Ma, Jiabao</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-5441-7608</orcidid></search><sort><creationdate>20240801</creationdate><title>Laggera alata Attenuates Inflammatory Response by Regulating Macrophage Polarization in Rheumatoid Arthritis Mice</title><author>Wei, Jiangcun ; Tang, Yunli ; Qin, Suhong ; Ma, Xiumei ; Zhong, Wen ; Yang, Peng ; Deng, Qingmei ; Ma, Jiabao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-eb03431466c542db8196a781df2eaff9a457437a3cd803b148f140a8be6a99ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Arthritis</topic><topic>Arthritis, Experimental - pathology</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Autoimmune diseases</topic><topic>Biochemistry</topic><topic>Biological Techniques</topic><topic>Biotechnology</topic><topic>blood serum</topic><topic>Body weight</topic><topic>Bone loss</topic><topic>bone resorption</topic><topic>Cell activation</topic><topic>Cell Biology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Computed tomography</topic><topic>Disease Models, Animal</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Femur</topic><topic>fluorescent antibody technique</topic><topic>histopathology</topic><topic>Human Genetics</topic><topic>Immunofluorescence</topic><topic>inflammation</topic><topic>Inflammation - pathology</topic><topic>Inflammatory response</topic><topic>Joints (anatomy)</topic><topic>Laggera</topic><topic>Laggera alata</topic><topic>Macrophages</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>micro-computed tomography</topic><topic>Original Paper</topic><topic>phenolic compounds</topic><topic>Phenols</topic><topic>phenotype</topic><topic>Phenotypes</topic><topic>Plant Extracts - pharmacology</topic><topic>Polarization</topic><topic>Protein Science</topic><topic>Rheumatoid arthritis</topic><topic>Serum levels</topic><topic>Staining</topic><topic>Thickness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Jiangcun</creatorcontrib><creatorcontrib>Tang, Yunli</creatorcontrib><creatorcontrib>Qin, Suhong</creatorcontrib><creatorcontrib>Ma, Xiumei</creatorcontrib><creatorcontrib>Zhong, Wen</creatorcontrib><creatorcontrib>Yang, Peng</creatorcontrib><creatorcontrib>Deng, Qingmei</creatorcontrib><creatorcontrib>Ma, Jiabao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Molecular biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Jiangcun</au><au>Tang, Yunli</au><au>Qin, Suhong</au><au>Ma, Xiumei</au><au>Zhong, Wen</au><au>Yang, Peng</au><au>Deng, Qingmei</au><au>Ma, Jiabao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laggera alata Attenuates Inflammatory Response by Regulating Macrophage Polarization in Rheumatoid Arthritis Mice</atitle><jtitle>Molecular biotechnology</jtitle><stitle>Mol Biotechnol</stitle><addtitle>Mol Biotechnol</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>66</volume><issue>8</issue><spage>1934</spage><epage>1941</epage><pages>1934-1941</pages><issn>1073-6085</issn><issn>1559-0305</issn><eissn>1559-0305</eissn><abstract>Rheumatoid arthritis (RA) is a type of joint injury, which can induce the activation of inflammatory factors and polarization of tissue macrophages. Total phenolics from
Laggera alata
(TPLA) has been reported to exhibit anti-inflammatory effect in various diseases. However, its specific function in RA is still unknown. Here, the protective properties of TPLA were studied in collagen-induced arthritis (CIA)-induced RA mice. RA mouse model was established through the CIA induction. Arthritis score, hind paw thickness, and the body weight of the RA mice were evaluated in each group. H&E staining was conducted in hind paw and joint tissues for histopathological staining. The distal femur was analyzed by microCT, and bone loss-related indicators were assessed. The expression of macrophage polarization markers was detected by immunofluorescence staining in RA mice. The serum levels of inflammatory markers were determined by enzyme-linked immunosorbent assay (ELISA). TPLA reduced the CIA-induced arthritis score and hind paw thickness in mice. The body weight of the CIA mouse was significantly increased by TPLA treatment. TPLA improved the CIA-induced histopathological changes in the hind paw and joint tissues from the mice. TPLA inhibited the bone loss and alleviated bone destruction in CIA mouse model. TPLA altered the macrophage phenotype from M1 macrophages into M2 in CIA mice. TPLA suppressed the levels of inflammatory markers both in the serum and joint tissues of the CIA mice. TPLA mitigated RA development by suppressing inflammatory reaction through the inhibition of M1 microphage polarization.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37493934</pmid><doi>10.1007/s12033-023-00808-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5441-7608</orcidid></addata></record> |
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| subjects | Animals anti-inflammatory activity Anti-Inflammatory Agents - pharmacology Arthritis Arthritis, Experimental - pathology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoimmune diseases Biochemistry Biological Techniques Biotechnology blood serum Body weight Bone loss bone resorption Cell activation Cell Biology Chemistry Chemistry and Materials Science Computed tomography Disease Models, Animal Enzyme-linked immunosorbent assay Femur fluorescent antibody technique histopathology Human Genetics Immunofluorescence inflammation Inflammation - pathology Inflammatory response Joints (anatomy) Laggera Laggera alata Macrophages Macrophages - immunology Male Mice Mice, Inbred DBA micro-computed tomography Original Paper phenolic compounds Phenols phenotype Phenotypes Plant Extracts - pharmacology Polarization Protein Science Rheumatoid arthritis Serum levels Staining Thickness |
| title | Laggera alata Attenuates Inflammatory Response by Regulating Macrophage Polarization in Rheumatoid Arthritis Mice |
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