Health-Promoting Potential of Mandarin Pomace Extracts Enriched with Phenolic Compounds
The aim of this work was to assess the effect of in vitro human digestion on the chemical composition (carbohydrates and phenolic compounds) and bioactivity of hydro-alcoholic-acid pomace extracts from two mandarin varieties (Clemenule and Ortanique) by measuring their antioxidant, antidiabetic, ant...
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| Veröffentlicht in: | Nutrients 2024-07, Vol.16 (14), p.2370 |
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| creator | Fernández-Fernández, Adriana Maite Dellacassa, Eduardo Curbelo, Romina Nardin, Tiziana Larcher, Roberto Medrano-Fernandez, Alejandra Del Castillo, María Dolores |
| description | The aim of this work was to assess the effect of in vitro human digestion on the chemical composition (carbohydrates and phenolic compounds) and bioactivity of hydro-alcoholic-acid pomace extracts from two mandarin varieties (Clemenule and Ortanique) by measuring their antioxidant, antidiabetic, anti-glycative, hypolipidemic, and anti-inflammatory properties. The phenolic compound profile showed that nobiletin was the main flavonoid found in the extracts and digests of Clemenule pomace and extract, while isosinensetin/sinensetin/tangeretin were the ones in the Ortanique samples. The digests of Clemenule and Ortanique extracts showed Folin reaction values of 9.74 and 9.20 mg gallic acid equivalents (GAE)/g of sample, ABTS values of 83.2 and 91.7 µmol Trolox equivalents (TE)/g of sample, and ORAC-FL values of 142.8 and 891.6 µmol TE/g of sample, respectively. Extracts (50-500 µg/mL) inhibited intracellular reactive oxygen species (ROS) formation in CCD-18Co cells under physiological and oxidative-induced conditions. Clemenule and Ortanique extract digests showed IC
values of 13.50 and 11.07 mg/mL for α-glucosidase, 28.79 and 69.64 mg/mL for α-amylase, and 16.50 and 12.77 mg/mL for AGEs, and 2.259 ± 0.267 and 0.713 ± 0.065 mg/mL for pancreatic lipase inhibition, respectively. Ortanique extract (250-1000 µg/mL) inhibited the production of nitric oxide in RAW264.7 macrophages under inflammation-induced conditions, and intracellular ROS formation. In conclusion, altogether, the results supported the potential of mandarin extracts to be used as health promoters by reducing the risk of non-communicable chronic diseases. |
| doi_str_mv | 10.3390/nu16142370 |
| format | Article |
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values of 13.50 and 11.07 mg/mL for α-glucosidase, 28.79 and 69.64 mg/mL for α-amylase, and 16.50 and 12.77 mg/mL for AGEs, and 2.259 ± 0.267 and 0.713 ± 0.065 mg/mL for pancreatic lipase inhibition, respectively. Ortanique extract (250-1000 µg/mL) inhibited the production of nitric oxide in RAW264.7 macrophages under inflammation-induced conditions, and intracellular ROS formation. In conclusion, altogether, the results supported the potential of mandarin extracts to be used as health promoters by reducing the risk of non-communicable chronic diseases.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16142370</identifier><identifier>PMID: 39064813</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>alpha-amylase ; Animals ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - pharmacology ; bioactive properties ; Biological activity ; Body fat ; Cell culture ; chemical composition ; Chronic illnesses ; Citrus - chemistry ; Citrus fruits ; Diabetes ; digestion ; Energy consumption ; Flavonoids ; Flavonoids - analysis ; Flavonoids - pharmacology ; Food ; Fruit - chemistry ; gallic acid ; Glucose ; health promotion ; Humans ; Hyperglycemia ; Hypoglycemic Agents - pharmacology ; Hypolipidemic Agents - pharmacology ; Inflammation ; macrophages ; Metabolic disorders ; Mice ; nitric oxide ; Obesity ; Phenols - analysis ; Phenols - pharmacology ; Plant Extracts - pharmacology ; pomace ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Reagents ; Solvents ; triacylglycerol lipase</subject><ispartof>Nutrients, 2024-07, Vol.16 (14), p.2370</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c273t-e27c98a0d2ffa8caa45d6c806babd01739b763fa13e1ade90e8257dee44f08fd3</cites><orcidid>0000-0002-5926-6239 ; 0000-0002-4764-4212 ; 0000-0001-7177-1062 ; 0000-0001-6309-5383 ; 0000-0003-4910-2318</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39064813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Fernández, Adriana Maite</creatorcontrib><creatorcontrib>Dellacassa, Eduardo</creatorcontrib><creatorcontrib>Curbelo, Romina</creatorcontrib><creatorcontrib>Nardin, Tiziana</creatorcontrib><creatorcontrib>Larcher, Roberto</creatorcontrib><creatorcontrib>Medrano-Fernandez, Alejandra</creatorcontrib><creatorcontrib>Del Castillo, María Dolores</creatorcontrib><title>Health-Promoting Potential of Mandarin Pomace Extracts Enriched with Phenolic Compounds</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The aim of this work was to assess the effect of in vitro human digestion on the chemical composition (carbohydrates and phenolic compounds) and bioactivity of hydro-alcoholic-acid pomace extracts from two mandarin varieties (Clemenule and Ortanique) by measuring their antioxidant, antidiabetic, anti-glycative, hypolipidemic, and anti-inflammatory properties. The phenolic compound profile showed that nobiletin was the main flavonoid found in the extracts and digests of Clemenule pomace and extract, while isosinensetin/sinensetin/tangeretin were the ones in the Ortanique samples. The digests of Clemenule and Ortanique extracts showed Folin reaction values of 9.74 and 9.20 mg gallic acid equivalents (GAE)/g of sample, ABTS values of 83.2 and 91.7 µmol Trolox equivalents (TE)/g of sample, and ORAC-FL values of 142.8 and 891.6 µmol TE/g of sample, respectively. Extracts (50-500 µg/mL) inhibited intracellular reactive oxygen species (ROS) formation in CCD-18Co cells under physiological and oxidative-induced conditions. Clemenule and Ortanique extract digests showed IC
values of 13.50 and 11.07 mg/mL for α-glucosidase, 28.79 and 69.64 mg/mL for α-amylase, and 16.50 and 12.77 mg/mL for AGEs, and 2.259 ± 0.267 and 0.713 ± 0.065 mg/mL for pancreatic lipase inhibition, respectively. Ortanique extract (250-1000 µg/mL) inhibited the production of nitric oxide in RAW264.7 macrophages under inflammation-induced conditions, and intracellular ROS formation. In conclusion, altogether, the results supported the potential of mandarin extracts to be used as health promoters by reducing the risk of non-communicable chronic diseases.</description><subject>alpha-amylase</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>bioactive properties</subject><subject>Biological activity</subject><subject>Body fat</subject><subject>Cell culture</subject><subject>chemical composition</subject><subject>Chronic illnesses</subject><subject>Citrus - chemistry</subject><subject>Citrus fruits</subject><subject>Diabetes</subject><subject>digestion</subject><subject>Energy consumption</subject><subject>Flavonoids</subject><subject>Flavonoids - analysis</subject><subject>Flavonoids - pharmacology</subject><subject>Food</subject><subject>Fruit - chemistry</subject><subject>gallic acid</subject><subject>Glucose</subject><subject>health promotion</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hypoglycemic Agents - 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The phenolic compound profile showed that nobiletin was the main flavonoid found in the extracts and digests of Clemenule pomace and extract, while isosinensetin/sinensetin/tangeretin were the ones in the Ortanique samples. The digests of Clemenule and Ortanique extracts showed Folin reaction values of 9.74 and 9.20 mg gallic acid equivalents (GAE)/g of sample, ABTS values of 83.2 and 91.7 µmol Trolox equivalents (TE)/g of sample, and ORAC-FL values of 142.8 and 891.6 µmol TE/g of sample, respectively. Extracts (50-500 µg/mL) inhibited intracellular reactive oxygen species (ROS) formation in CCD-18Co cells under physiological and oxidative-induced conditions. Clemenule and Ortanique extract digests showed IC
values of 13.50 and 11.07 mg/mL for α-glucosidase, 28.79 and 69.64 mg/mL for α-amylase, and 16.50 and 12.77 mg/mL for AGEs, and 2.259 ± 0.267 and 0.713 ± 0.065 mg/mL for pancreatic lipase inhibition, respectively. Ortanique extract (250-1000 µg/mL) inhibited the production of nitric oxide in RAW264.7 macrophages under inflammation-induced conditions, and intracellular ROS formation. In conclusion, altogether, the results supported the potential of mandarin extracts to be used as health promoters by reducing the risk of non-communicable chronic diseases.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39064813</pmid><doi>10.3390/nu16142370</doi><orcidid>https://orcid.org/0000-0002-5926-6239</orcidid><orcidid>https://orcid.org/0000-0002-4764-4212</orcidid><orcidid>https://orcid.org/0000-0001-7177-1062</orcidid><orcidid>https://orcid.org/0000-0001-6309-5383</orcidid><orcidid>https://orcid.org/0000-0003-4910-2318</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | alpha-amylase Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology bioactive properties Biological activity Body fat Cell culture chemical composition Chronic illnesses Citrus - chemistry Citrus fruits Diabetes digestion Energy consumption Flavonoids Flavonoids - analysis Flavonoids - pharmacology Food Fruit - chemistry gallic acid Glucose health promotion Humans Hyperglycemia Hypoglycemic Agents - pharmacology Hypolipidemic Agents - pharmacology Inflammation macrophages Metabolic disorders Mice nitric oxide Obesity Phenols - analysis Phenols - pharmacology Plant Extracts - pharmacology pomace Reactive oxygen species Reactive Oxygen Species - metabolism Reagents Solvents triacylglycerol lipase |
| title | Health-Promoting Potential of Mandarin Pomace Extracts Enriched with Phenolic Compounds |
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