Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/cRGD targeted photodynamic therapy

Photodynamic therapy (PDT) is a clinically-approved cancer treatment that is based on production of cytotoxic reactive oxygen species to induce cell death. However, its efficiency depends on distribution of photosensitizer (PS) and depth of light penetration through the tissues. Tendency of patholog...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2024-10, Vol.259, p.113010, Article 113010
Hauptverfasser:	Porubský, Martin, Hodoň, Jiří, Stanková, Jarmila, Džubák, Petr, Hajdúch, Marián, Urban, Milan, Hlaváč, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Activatable Biotin Biotin - chemistry BODIPY Boron Compounds - chemistry Boron Compounds - pharmacology cancer therapy cell death Cell Survival - drug effects cRGD peptide cytotoxicity electron transfer HeLa Cells Humans Hydrogen-Ion Concentration hydrophilicity hydrophobicity Infrared Rays Integrin integrins lighting moieties Near-infrared neoplasm cells peptides Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology photobiology photochemistry Photochemotherapy Photodynamic Photosensitizer photosensitizing agents Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology phototoxicity reactive oxygen species water solubility
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