Chemical composition and bioactivity of essential oils from Cistus ladanifer L., Pistacia lentiscus L., and Matricaria chamomilla L

The objective of this study was to characterize the volatile compounds from the aerial part of Cistus ladanifer L., Pistacia lentiscus L., and Matricaria chamomilla L., members of Cistaceae, Anacardiaceae, and Asteraceae families, respectively; and assess their potential antioxidant, antimicrobial, and enzyme inhibitory properties. The essential oils were analyzed using gas chromatography-mass spectrometry (GC-MS-MS) analysis. The outcomes revealed distinct chemical profiles indicative of specific chemotypes within each species. Indeed, M. chamomilla essential oil (MCEO) contained sabinene (16.03 %), camphor (11.22 %), 3,6-dihydrochamazulene (14.22 %), and chamazulene (12.84 %) as its primary constituents. C. ladanifer essential oil (CLEO) prominently featured camphene (31.5 %), α-pinene (15.76%), and bornyl acetate (15.73 %), while P. lentiscus essential oil (PLEO) was rich in D-limonene (21 %), β-myrcene (14.89 %), α-pinene (13.93 %), and terpinen-4-ol (9.75 %). Remarkably, PLEO exhibited significant antioxidant activity across multiple assays, demonstrating inhibitory values of 72.07 ± 4.06 mg TE/g of extract (Cuprac), 45.74 ± 1.23 mg TE/g of extract (FRAP), 30.89 ± 1.69 mg EDTAE/g of extract (Chelating), 26.71 ± 1.84 mmol TE/g of extract (Phosphomolybdenum), 15.55 ± 0.84 mg TE/g of extract (ABTS), and 2.30 ± 0.22 mg TE/g of extract (DPPH). The results showed that the microorganisms under examination varied in their sensitivity to essential oils and the inhibitory zone ranged between 25 and 57 mm. The inhibitory effects of the essential oils were investigated against enzymes associated with human pathologies. As findings, CLEO demonstrated substantial inhibition of tyrosinase (10.22 ± 0.13 mg KAE/g of extract) and acetylcholinesterase (4.71 ± 0.97 mg GALAE/g of extract), outperforming other essential oils that displayed moderate activities. These important biological effects of the oils tested qualify these plants as an interesting source of phytochemicals with medicinal actions. [Display omitted] •Many classes of terpenes were found in the essential oils studied.•All oils have good potentials as antioxidant and antimicrobial agents.•CLEO and MCEO exhibited the strongest inhibitory activity against tyrosinase.