Dandouchi Polypeptide Alleviates Depressive-like Behavior and Promotes Hippocampal Neurogenesis by Activating the TRIM67/NF-κB Pathway in CUMS-Induced Mice

Background: Dandouchi polypeptide (DDCP) is derived from Semen Sojae Praeparatum (Dandouchi in Chinese), a fermented product of Glycine max (L.) Merr. Semen Sojae Praeparatum is widely used in the food industry for its unique flavor and nutritional value, and DDCP, as its derivative, also shows pote...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2024-07, Vol.72 (30), p.16726-16738
Hauptverfasser:	Wang, Zhongda, Cheng, Xiaolan, Shuang, Ruonan, Gao, Tiantian, Zhao, Tong, Hou, Dahai, Zhang, Yili, Yang, Jiangsheng, Tao, Weiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antidepressants Antidepressive Agents - chemistry Antidepressive Agents - pharmacology Behavior, Animal - drug effects Bioactive Constituents, Metabolites, and Functions Dependoparvovirus Depression - drug therapy Depression - genetics Depression - metabolism Disease Models, Animal fermented foods flavor fluorescent antibody technique food chemistry food industry Glycine max hippocampus Hippocampus - drug effects Hippocampus - metabolism Humans immunohistochemistry Male Mice Mice, Inbred C57BL neurogenesis Neurogenesis - drug effects NF-kappa B - genetics NF-kappa B - metabolism nutritive value Peptides - administration & dosage Peptides - chemistry Peptides - pharmacology polypeptides protective effect Signal Transduction - drug effects Stress, Psychological - drug therapy therapeutics Tripartite Motif Proteins - genetics Tripartite Motif Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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