Neurodevelopmental effects of prenatal Bisphenol A exposure on the role of microRNA regulating NMDA receptor subunits in the male rat hippocampus

•Prenatal BPA exposure at 5 mg/kg/day downregulates the expression of miR-19a and miR-539 which is responsible for regulating the NMDA receptor subunit proteins in the male rat hippocampus.•The downregulation of miR-19a and miR-539 reduces the expression of GRIN2A and GRIN2B genes in the male rat hi...

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Veröffentlicht in:	Physiology & behavior 2024-06, Vol.280, p.114546-114546, Article 114546
Hauptverfasser:	Nayan, Norazirah Mat, Kadir, Siti Hamimah Sheikh Abd, Husin, Andrean, Siran, Rosfaiizah
Format:	Artikel
Sprache:	eng
Schlagworte:	adolescents Animals Benzhydryl Compounds - toxicity Bisphenol A cesarean section epigenetics fearfulness Female fetus hippocampus Hippocampus - drug effects Hippocampus - metabolism Male males memory microRNA MicroRNA expression MicroRNAs - genetics MicroRNAs - metabolism NMDA receptor subunits Phenols - toxicity Pregnancy Prenatal Prenatal Exposure Delayed Effects - chemically induced progeny Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Western blotting
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