Exploring the biological activities and potential therapeutic applications of agro-industrial waste products through non-clinical studies: A systematic review
The latent potential of active ingredients derived from agro-industrial waste remains largely untapped and offers a wealth of unexplored resources. While these types of materials have applications in various fields, their ability to benefit human health needs to be further explored and investigated....
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| Veröffentlicht in: | The Science of the total environment 2024-11, Vol.950, p.175317, Article 175317 |
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| creator | Schiebel, Carolina Silva Bueno, Laryssa Regis Pargas, Romulo Barreiro de Mello Braga, Lara Luisa Valerio da Silva, Karien Sauruk Fernandes, Ana Carolina Vieira Ulysséa dos Santos Maia, Mateus Henrique de Oliveira, Natalia Mulinari Turin Bach, Camila Maria-Ferreira, Daniele |
| description | The latent potential of active ingredients derived from agro-industrial waste remains largely untapped and offers a wealth of unexplored resources. While these types of materials have applications in various fields, their ability to benefit human health needs to be further explored and investigated. This systematic review was conducted to systematically evaluate non-clinical studies that have investigated the biological effects of fractions, extracts and bioactive compounds from agro-industrial wastes and their potential therapeutic applications. Articles were selected via PubMed, Embase and Medline using the descriptors (by-products[title/abstract]) AND (agro-industrial[title/abstract]). The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42024491021. After a detailed analysis based on inclusion and exclusion criteria, a total of 38 articles were used for data extraction and discussion of the results. Information was found from in vitro and in vivo experiments investigating a variety of residues from the agro-industry. The studies investigated peels, pomace/bagasse, pulp, seeds, aerial parts, cereals/grains and other types of waste. The most studied activities include mainly antioxidant and anti-inflammatory effects, but other activities such as antimicrobial, cytotoxic, antiproliferative, antinociceptive, hypoglycemic, antihyperglycemic and anticoagulant effects have also been described. Finally, the studies included in this review demonstrate the potential of agro-industrial waste and can drive future research with a focus on clinical application.
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•Agro-industrial waste provides biomolecules with antioxidant, anti-inflammatory and antimicrobial properties.•Biomolecules obtained from agro-industrial waste have significant potential for medical and pharmaceutical applications.•Agro-industrial residues are promising for applications in biotechnology. |
| doi_str_mv | 10.1016/j.scitotenv.2024.175317 |
| format | Article |
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[Display omitted]
•Agro-industrial waste provides biomolecules with antioxidant, anti-inflammatory and antimicrobial properties.•Biomolecules obtained from agro-industrial waste have significant potential for medical and pharmaceutical applications.•Agro-industrial residues are promising for applications in biotechnology.</description><identifier>ISSN: 0048-9697</identifier><identifier>ISSN: 1879-1026</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2024.175317</identifier><identifier>PMID: 39111448</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>agricultural industry ; agricultural wastes ; Agro-industrial by-products ; Agro-industrial residues ; Agro-industrial waste ; Anti-inflammatory ; anticoagulants ; Antioxidant ; antioxidants ; bagasse ; Bioactive ; Biological activities ; cytotoxicity ; environment ; glycemic effect ; human health ; pomace ; pulp ; systematic review ; Therapeutics</subject><ispartof>The Science of the total environment, 2024-11, Vol.950, p.175317, Article 175317</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c280t-519b168ec9e28f6d5ca786552291459249750a0a0b38aa0ad0c9d270aa6931a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2024.175317$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39111448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schiebel, Carolina Silva</creatorcontrib><creatorcontrib>Bueno, Laryssa Regis</creatorcontrib><creatorcontrib>Pargas, Romulo Barreiro</creatorcontrib><creatorcontrib>de Mello Braga, Lara Luisa Valerio</creatorcontrib><creatorcontrib>da Silva, Karien Sauruk</creatorcontrib><creatorcontrib>Fernandes, Ana Carolina Vieira Ulysséa</creatorcontrib><creatorcontrib>dos Santos Maia, Mateus Henrique</creatorcontrib><creatorcontrib>de Oliveira, Natalia Mulinari Turin</creatorcontrib><creatorcontrib>Bach, Camila</creatorcontrib><creatorcontrib>Maria-Ferreira, Daniele</creatorcontrib><title>Exploring the biological activities and potential therapeutic applications of agro-industrial waste products through non-clinical studies: A systematic review</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>The latent potential of active ingredients derived from agro-industrial waste remains largely untapped and offers a wealth of unexplored resources. While these types of materials have applications in various fields, their ability to benefit human health needs to be further explored and investigated. This systematic review was conducted to systematically evaluate non-clinical studies that have investigated the biological effects of fractions, extracts and bioactive compounds from agro-industrial wastes and their potential therapeutic applications. Articles were selected via PubMed, Embase and Medline using the descriptors (by-products[title/abstract]) AND (agro-industrial[title/abstract]). The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42024491021. After a detailed analysis based on inclusion and exclusion criteria, a total of 38 articles were used for data extraction and discussion of the results. Information was found from in vitro and in vivo experiments investigating a variety of residues from the agro-industry. The studies investigated peels, pomace/bagasse, pulp, seeds, aerial parts, cereals/grains and other types of waste. The most studied activities include mainly antioxidant and anti-inflammatory effects, but other activities such as antimicrobial, cytotoxic, antiproliferative, antinociceptive, hypoglycemic, antihyperglycemic and anticoagulant effects have also been described. Finally, the studies included in this review demonstrate the potential of agro-industrial waste and can drive future research with a focus on clinical application.
[Display omitted]
•Agro-industrial waste provides biomolecules with antioxidant, anti-inflammatory and antimicrobial properties.•Biomolecules obtained from agro-industrial waste have significant potential for medical and pharmaceutical applications.•Agro-industrial residues are promising for applications in biotechnology.</description><subject>agricultural industry</subject><subject>agricultural wastes</subject><subject>Agro-industrial by-products</subject><subject>Agro-industrial residues</subject><subject>Agro-industrial waste</subject><subject>Anti-inflammatory</subject><subject>anticoagulants</subject><subject>Antioxidant</subject><subject>antioxidants</subject><subject>bagasse</subject><subject>Bioactive</subject><subject>Biological activities</subject><subject>cytotoxicity</subject><subject>environment</subject><subject>glycemic effect</subject><subject>human health</subject><subject>pomace</subject><subject>pulp</subject><subject>systematic review</subject><subject>Therapeutics</subject><issn>0048-9697</issn><issn>1879-1026</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkc1uGyEUhVHVqnHTvkLLsptxuTAzDN1ZUfojReqmXSMM1w7WGKbAOMnL9FnL1Gm2gcVd8J1z0D2EfAC2Bgb9p8M6W19iwXBac8bbNchOgHxBVjBI1QDj_UuyYqwdGtUreUHe5Hxg9cgBXpMLoQCgbYcV-XN9P40x-bCn5Rbp1scx7r01IzW2-JMvHjM1wdFpCSu-PlQumQnn4i010zRWuvgYMo07avYpNj64OZe0sHcmF6RTim62JVdpivP-loYYGjv68C8ol9nVlM90Q_NDxY9mcU548nj3lrzamTHju8d5SX59uf559a25-fH1-9XmprF8YKXpQG2hH9Aq5MOud501cui7jnMFbad4q2THTL1bMZg6HbPKccmM6ZUAI8Ql-Xj2rV_9PWMu-uizxXE0AeOctYBOSC5Yy59HmWK9ACUWVJ5Rm2LOCXd6Sv5o0oMGppce9UE_9aiXHvW5x6p8_xgyb4_onnT_i6vA5gxg3UrdVFqMMFh0PqEt2kX_bMhflKm29Q</recordid><startdate>20241110</startdate><enddate>20241110</enddate><creator>Schiebel, Carolina Silva</creator><creator>Bueno, Laryssa Regis</creator><creator>Pargas, Romulo Barreiro</creator><creator>de Mello Braga, Lara Luisa Valerio</creator><creator>da Silva, Karien Sauruk</creator><creator>Fernandes, Ana Carolina Vieira Ulysséa</creator><creator>dos Santos Maia, Mateus Henrique</creator><creator>de Oliveira, Natalia Mulinari Turin</creator><creator>Bach, Camila</creator><creator>Maria-Ferreira, Daniele</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20241110</creationdate><title>Exploring the biological activities and potential therapeutic applications of agro-industrial waste products through non-clinical studies: A systematic review</title><author>Schiebel, Carolina Silva ; 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While these types of materials have applications in various fields, their ability to benefit human health needs to be further explored and investigated. This systematic review was conducted to systematically evaluate non-clinical studies that have investigated the biological effects of fractions, extracts and bioactive compounds from agro-industrial wastes and their potential therapeutic applications. Articles were selected via PubMed, Embase and Medline using the descriptors (by-products[title/abstract]) AND (agro-industrial[title/abstract]). The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42024491021. After a detailed analysis based on inclusion and exclusion criteria, a total of 38 articles were used for data extraction and discussion of the results. Information was found from in vitro and in vivo experiments investigating a variety of residues from the agro-industry. The studies investigated peels, pomace/bagasse, pulp, seeds, aerial parts, cereals/grains and other types of waste. The most studied activities include mainly antioxidant and anti-inflammatory effects, but other activities such as antimicrobial, cytotoxic, antiproliferative, antinociceptive, hypoglycemic, antihyperglycemic and anticoagulant effects have also been described. Finally, the studies included in this review demonstrate the potential of agro-industrial waste and can drive future research with a focus on clinical application.
[Display omitted]
•Agro-industrial waste provides biomolecules with antioxidant, anti-inflammatory and antimicrobial properties.•Biomolecules obtained from agro-industrial waste have significant potential for medical and pharmaceutical applications.•Agro-industrial residues are promising for applications in biotechnology.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39111448</pmid><doi>10.1016/j.scitotenv.2024.175317</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0048-9697 |
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| source | Elsevier ScienceDirect Journals |
| subjects | agricultural industry agricultural wastes Agro-industrial by-products Agro-industrial residues Agro-industrial waste Anti-inflammatory anticoagulants Antioxidant antioxidants bagasse Bioactive Biological activities cytotoxicity environment glycemic effect human health pomace pulp systematic review Therapeutics |
| title | Exploring the biological activities and potential therapeutic applications of agro-industrial waste products through non-clinical studies: A systematic review |
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