Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway
Due to the immature intestinal digestion, immunity, and barrier functions, weaned infants are more susceptible to pathogens and develop diarrhea. Microplastics (MPs), pervasive contaminants in food, water, and air, have unknown effects on the intestinal development of weaned infants. This study expl...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2024-07, Vol.72 (30), p.16638-16650 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Zou, Dongbin Yang, Yun Ji, Fengjie Lv, Renlong Wu, Hongzhi Hou, Guanyu Xu, Tieshan Zhou, Hanlin Hu, Chengjun |
| description | Due to the immature intestinal digestion, immunity, and barrier functions, weaned infants are more susceptible to pathogens and develop diarrhea. Microplastics (MPs), pervasive contaminants in food, water, and air, have unknown effects on the intestinal development of weaned infants. This study explored the impact of polystyrene MPs on intestinal development using a weaned piglet model. Piglets in the control group received a basal diet, and those in the experimental groups received a basal diet contaminated with 150 mg/kg polystyrene MPs. The results showed that exposure to polystyrene MPs increased the diarrhea incidence and impaired the intestinal barrier function of weaned piglets. Notably, the exposure led to oxidative stress and inflammation in the intestine. Furthermore, polystyrene MPs-treated weaned piglets showed a reduced level of intestinal angiogenesis. Mechanistically, polystyrene MPs suppressed methyltransferase-like 3 (METTL3) expression by increasing reactive oxygen species (ROS) production, consequently destabilizing angiogenic factors’ mRNA and hindering intestinal angiogenesis. In summary, polystyrene MPs contamination in the diet increases diarrhea and compromises intestinal angiogenesis through the ROS/METTL3 pathway, demonstrating their toxic effects on the intestine health of weaned infants. |
| doi_str_mv | 10.1021/acs.jafc.4c03238 |
| format | Article |
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Microplastics (MPs), pervasive contaminants in food, water, and air, have unknown effects on the intestinal development of weaned infants. This study explored the impact of polystyrene MPs on intestinal development using a weaned piglet model. Piglets in the control group received a basal diet, and those in the experimental groups received a basal diet contaminated with 150 mg/kg polystyrene MPs. The results showed that exposure to polystyrene MPs increased the diarrhea incidence and impaired the intestinal barrier function of weaned piglets. Notably, the exposure led to oxidative stress and inflammation in the intestine. Furthermore, polystyrene MPs-treated weaned piglets showed a reduced level of intestinal angiogenesis. Mechanistically, polystyrene MPs suppressed methyltransferase-like 3 (METTL3) expression by increasing reactive oxygen species (ROS) production, consequently destabilizing angiogenic factors’ mRNA and hindering intestinal angiogenesis. In summary, polystyrene MPs contamination in the diet increases diarrhea and compromises intestinal angiogenesis through the ROS/METTL3 pathway, demonstrating their toxic effects on the intestine health of weaned infants.</description><identifier>ISSN: 0021-8561</identifier><identifier>ISSN: 1520-5118</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.4c03238</identifier><identifier>PMID: 39012162</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Agricultural and Environmental Chemistry ; air ; Angiogenesis ; Animals ; diarrhea ; Diarrhea - chemically induced ; Diarrhea - metabolism ; Diarrhea - physiopathology ; diet ; digestion ; food chemistry ; food contamination ; Humans ; immunity ; inflammation ; Intestinal Mucosa - metabolism ; intestines ; Intestines - blood supply ; Intestines - drug effects ; Male ; microplastics ; Microplastics - toxicity ; Oxidative Stress ; piglets ; polystyrenes ; Polystyrenes - adverse effects ; Polystyrenes - toxicity ; reactive oxygen species ; Reactive Oxygen Species - metabolism ; Swine ; toxicity</subject><ispartof>Journal of agricultural and food chemistry, 2024-07, Vol.72 (30), p.16638-16650</ispartof><rights>2024 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a252t-84ff4ca4cf997c4c2c3847ae6cb3cb12d3c6b05c1d36f22bada89be9f0afd5ba3</cites><orcidid>0000-0001-6406-6445</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.4c03238$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.4c03238$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39012162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zou, Dongbin</creatorcontrib><creatorcontrib>Yang, Yun</creatorcontrib><creatorcontrib>Ji, Fengjie</creatorcontrib><creatorcontrib>Lv, Renlong</creatorcontrib><creatorcontrib>Wu, Hongzhi</creatorcontrib><creatorcontrib>Hou, Guanyu</creatorcontrib><creatorcontrib>Xu, Tieshan</creatorcontrib><creatorcontrib>Zhou, Hanlin</creatorcontrib><creatorcontrib>Hu, Chengjun</creatorcontrib><title>Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Due to the immature intestinal digestion, immunity, and barrier functions, weaned infants are more susceptible to pathogens and develop diarrhea. Microplastics (MPs), pervasive contaminants in food, water, and air, have unknown effects on the intestinal development of weaned infants. This study explored the impact of polystyrene MPs on intestinal development using a weaned piglet model. Piglets in the control group received a basal diet, and those in the experimental groups received a basal diet contaminated with 150 mg/kg polystyrene MPs. The results showed that exposure to polystyrene MPs increased the diarrhea incidence and impaired the intestinal barrier function of weaned piglets. Notably, the exposure led to oxidative stress and inflammation in the intestine. Furthermore, polystyrene MPs-treated weaned piglets showed a reduced level of intestinal angiogenesis. Mechanistically, polystyrene MPs suppressed methyltransferase-like 3 (METTL3) expression by increasing reactive oxygen species (ROS) production, consequently destabilizing angiogenic factors’ mRNA and hindering intestinal angiogenesis. In summary, polystyrene MPs contamination in the diet increases diarrhea and compromises intestinal angiogenesis through the ROS/METTL3 pathway, demonstrating their toxic effects on the intestine health of weaned infants.</description><subject>Agricultural and Environmental Chemistry</subject><subject>air</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>diarrhea</subject><subject>Diarrhea - chemically induced</subject><subject>Diarrhea - metabolism</subject><subject>Diarrhea - physiopathology</subject><subject>diet</subject><subject>digestion</subject><subject>food chemistry</subject><subject>food contamination</subject><subject>Humans</subject><subject>immunity</subject><subject>inflammation</subject><subject>Intestinal Mucosa - metabolism</subject><subject>intestines</subject><subject>Intestines - blood supply</subject><subject>Intestines - drug effects</subject><subject>Male</subject><subject>microplastics</subject><subject>Microplastics - toxicity</subject><subject>Oxidative Stress</subject><subject>piglets</subject><subject>polystyrenes</subject><subject>Polystyrenes - adverse effects</subject><subject>Polystyrenes - toxicity</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Swine</subject><subject>toxicity</subject><issn>0021-8561</issn><issn>1520-5118</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PwkAYhDdGo4jePZk9erC4H_3YHgmikkAkiufm7XYXakqL-7Yx_HsXQW_G01yemUxmCLnibMCZ4HegcfAOVg9CzaSQ6oj0eCRYEHGujkmPeSZQUczPyDniO2NMRQk7JWcyZVzwWPRINW-qLbZbZ2pDZ6V2zaYCbEuNdAQdGqT3JTi3MkChLuhkvYHSIZ3UrfFUDRUd1suyWXo7lkjblWu65cqroS_Pr3ez8WIxlXQO7eoTthfkxEKF5vKgffL2MF6MnoLp8-NkNJwGICLRBiq0NtQQapumiQ610FKFCZhY51LnXBRSxzmLNC9kbIXIoQCV5ia1DGwR5SD75Gafu3HNR-eLZusStakqqE3TYSZ5JBPBVBz_jzLFha8hE4-yPepHQnTGZhtXrsFtM86y3R2ZvyPb3ZEd7vCW60N6l69N8Wv42d8Dt3vg29p0zi-Kf-d9Aeykl_Y</recordid><startdate>20240731</startdate><enddate>20240731</enddate><creator>Zou, Dongbin</creator><creator>Yang, Yun</creator><creator>Ji, Fengjie</creator><creator>Lv, Renlong</creator><creator>Wu, Hongzhi</creator><creator>Hou, Guanyu</creator><creator>Xu, Tieshan</creator><creator>Zhou, Hanlin</creator><creator>Hu, Chengjun</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-6406-6445</orcidid></search><sort><creationdate>20240731</creationdate><title>Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway</title><author>Zou, Dongbin ; Yang, Yun ; Ji, Fengjie ; Lv, Renlong ; Wu, Hongzhi ; Hou, Guanyu ; Xu, Tieshan ; Zhou, Hanlin ; Hu, Chengjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a252t-84ff4ca4cf997c4c2c3847ae6cb3cb12d3c6b05c1d36f22bada89be9f0afd5ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Agricultural and Environmental Chemistry</topic><topic>air</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>diarrhea</topic><topic>Diarrhea - chemically induced</topic><topic>Diarrhea - metabolism</topic><topic>Diarrhea - physiopathology</topic><topic>diet</topic><topic>digestion</topic><topic>food chemistry</topic><topic>food contamination</topic><topic>Humans</topic><topic>immunity</topic><topic>inflammation</topic><topic>Intestinal Mucosa - metabolism</topic><topic>intestines</topic><topic>Intestines - blood supply</topic><topic>Intestines - drug effects</topic><topic>Male</topic><topic>microplastics</topic><topic>Microplastics - toxicity</topic><topic>Oxidative Stress</topic><topic>piglets</topic><topic>polystyrenes</topic><topic>Polystyrenes - adverse effects</topic><topic>Polystyrenes - toxicity</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Swine</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zou, Dongbin</creatorcontrib><creatorcontrib>Yang, Yun</creatorcontrib><creatorcontrib>Ji, Fengjie</creatorcontrib><creatorcontrib>Lv, Renlong</creatorcontrib><creatorcontrib>Wu, Hongzhi</creatorcontrib><creatorcontrib>Hou, Guanyu</creatorcontrib><creatorcontrib>Xu, Tieshan</creatorcontrib><creatorcontrib>Zhou, Hanlin</creatorcontrib><creatorcontrib>Hu, Chengjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zou, Dongbin</au><au>Yang, Yun</au><au>Ji, Fengjie</au><au>Lv, Renlong</au><au>Wu, Hongzhi</au><au>Hou, Guanyu</au><au>Xu, Tieshan</au><au>Zhou, Hanlin</au><au>Hu, Chengjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2024-07-31</date><risdate>2024</risdate><volume>72</volume><issue>30</issue><spage>16638</spage><epage>16650</epage><pages>16638-16650</pages><issn>0021-8561</issn><issn>1520-5118</issn><eissn>1520-5118</eissn><abstract>Due to the immature intestinal digestion, immunity, and barrier functions, weaned infants are more susceptible to pathogens and develop diarrhea. Microplastics (MPs), pervasive contaminants in food, water, and air, have unknown effects on the intestinal development of weaned infants. This study explored the impact of polystyrene MPs on intestinal development using a weaned piglet model. Piglets in the control group received a basal diet, and those in the experimental groups received a basal diet contaminated with 150 mg/kg polystyrene MPs. The results showed that exposure to polystyrene MPs increased the diarrhea incidence and impaired the intestinal barrier function of weaned piglets. Notably, the exposure led to oxidative stress and inflammation in the intestine. Furthermore, polystyrene MPs-treated weaned piglets showed a reduced level of intestinal angiogenesis. Mechanistically, polystyrene MPs suppressed methyltransferase-like 3 (METTL3) expression by increasing reactive oxygen species (ROS) production, consequently destabilizing angiogenic factors’ mRNA and hindering intestinal angiogenesis. In summary, polystyrene MPs contamination in the diet increases diarrhea and compromises intestinal angiogenesis through the ROS/METTL3 pathway, demonstrating their toxic effects on the intestine health of weaned infants.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>39012162</pmid><doi>10.1021/acs.jafc.4c03238</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-6406-6445</orcidid></addata></record> |
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| subjects | Agricultural and Environmental Chemistry air Angiogenesis Animals diarrhea Diarrhea - chemically induced Diarrhea - metabolism Diarrhea - physiopathology diet digestion food chemistry food contamination Humans immunity inflammation Intestinal Mucosa - metabolism intestines Intestines - blood supply Intestines - drug effects Male microplastics Microplastics - toxicity Oxidative Stress piglets polystyrenes Polystyrenes - adverse effects Polystyrenes - toxicity reactive oxygen species Reactive Oxygen Species - metabolism Swine toxicity |
| title | Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway |
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