Investigation of glucagon-like peptide-1 response to six oral carbohydrates in ponies
Glucagon-like peptide-1 (GLP-1), the principal incretin in horses, may play a role in the pathophysiology of insulin dysregulation (ID). This study aimed to describe its concentration in response to three preserved forages and four dynamic tests for ID in ponies. Twelve adult ponies of mixed ID stat...
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| Veröffentlicht in: | The veterinary journal (1997) 2024-06, Vol.305, p.106110, Article 106110 |
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| container_title | The veterinary journal (1997) |
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| creator | Carslake, H.B. Pinchbeck, G.L. Argo, C.M. Dugdale, A.H.A. McGowan, C.M. |
| description | Glucagon-like peptide-1 (GLP-1), the principal incretin in horses, may play a role in the pathophysiology of insulin dysregulation (ID). This study aimed to describe its concentration in response to three preserved forages and four dynamic tests for ID in ponies. Twelve adult ponies of mixed ID status were given a meal of hay, soaked hay or haylage, an in-feed oral glucose test (OGT), oral sugar test (OST), an oral test using a proprietary breakfast cereal (WEET) or a combined glucose-insulin tolerance test (CGIT) weekly in a randomised cross-over study. Glucose, insulin and GLP-1 concentrations were measured before and following each intervention. Ponies were designated ID or non-ID and insulin resistant (IR) or non-IR according to OGT and CGIT results, respectively.
All interventions apart from the CGIT provoked a GLP-1 response within 30 min. The OGT and WEET interventions, (containing the greatest dose of non-structural carbohydrate, 1.06 and 1 g/kg BW, respectively), resulted in a greater area under the curve (AUC) for GLP-1 compared to all other interventions (P |
| doi_str_mv | 10.1016/j.tvjl.2024.106110 |
| format | Article |
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All interventions apart from the CGIT provoked a GLP-1 response within 30 min. The OGT and WEET interventions, (containing the greatest dose of non-structural carbohydrate, 1.06 and 1 g/kg BW, respectively), resulted in a greater area under the curve (AUC) for GLP-1 compared to all other interventions (P < 0.001). No difference in GLP-1 response was detected according to ID or IR status, despite there being strong positive correlations (rs [95 % CI]) between GLP-1 and insulin concentrations measured at individual time points (0.67 [0.62 – 0.71]; P < 0.001) and as AUC (0.66 [0.49–0.79], P < 0.001). These data do not support of the use of GLP-1 as an adjunctive diagnostic test for ID or IR, as defined by conventional intravenous or oral dynamic tests.
•Glucagon-like peptide-1 (GLP-1) was detected within 30 min of oral carbohydrates.•GLP-1 response was associated with dose of non-structural carbohydrate.•Soaking hay resulted in a decreased GLP-1 response.•GLP-1 and insulin responses were correlated.•Insulin dysregulation status did not affect GLP-1 response.</description><identifier>ISSN: 1090-0233</identifier><identifier>ISSN: 1532-2971</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2024.106110</identifier><identifier>PMID: 38604332</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>adults ; breakfast cereals ; cross-over studies ; Enteroinsular axis ; glucagon-like peptide 1 ; glucose ; hay ; haylage ; Horse ; Incretin ; insulin ; Insulin dysregulation ; insulin resistance ; intravenous injection ; Laminitis ; pathophysiology ; secretin</subject><ispartof>The veterinary journal (1997), 2024-06, Vol.305, p.106110, Article 106110</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024. Published by Elsevier Ltd.</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-ecd34f9aff7048f8c426953ead0e9d5faacb1c559e5329e8f763e24b50f2b1f43</citedby><cites>FETCH-LOGICAL-c433t-ecd34f9aff7048f8c426953ead0e9d5faacb1c559e5329e8f763e24b50f2b1f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tvjl.2024.106110$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38604332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carslake, H.B.</creatorcontrib><creatorcontrib>Pinchbeck, G.L.</creatorcontrib><creatorcontrib>Argo, C.M.</creatorcontrib><creatorcontrib>Dugdale, A.H.A.</creatorcontrib><creatorcontrib>McGowan, C.M.</creatorcontrib><title>Investigation of glucagon-like peptide-1 response to six oral carbohydrates in ponies</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>Glucagon-like peptide-1 (GLP-1), the principal incretin in horses, may play a role in the pathophysiology of insulin dysregulation (ID). This study aimed to describe its concentration in response to three preserved forages and four dynamic tests for ID in ponies. Twelve adult ponies of mixed ID status were given a meal of hay, soaked hay or haylage, an in-feed oral glucose test (OGT), oral sugar test (OST), an oral test using a proprietary breakfast cereal (WEET) or a combined glucose-insulin tolerance test (CGIT) weekly in a randomised cross-over study. Glucose, insulin and GLP-1 concentrations were measured before and following each intervention. Ponies were designated ID or non-ID and insulin resistant (IR) or non-IR according to OGT and CGIT results, respectively.
All interventions apart from the CGIT provoked a GLP-1 response within 30 min. The OGT and WEET interventions, (containing the greatest dose of non-structural carbohydrate, 1.06 and 1 g/kg BW, respectively), resulted in a greater area under the curve (AUC) for GLP-1 compared to all other interventions (P < 0.001). No difference in GLP-1 response was detected according to ID or IR status, despite there being strong positive correlations (rs [95 % CI]) between GLP-1 and insulin concentrations measured at individual time points (0.67 [0.62 – 0.71]; P < 0.001) and as AUC (0.66 [0.49–0.79], P < 0.001). These data do not support of the use of GLP-1 as an adjunctive diagnostic test for ID or IR, as defined by conventional intravenous or oral dynamic tests.
•Glucagon-like peptide-1 (GLP-1) was detected within 30 min of oral carbohydrates.•GLP-1 response was associated with dose of non-structural carbohydrate.•Soaking hay resulted in a decreased GLP-1 response.•GLP-1 and insulin responses were correlated.•Insulin dysregulation status did not affect GLP-1 response.</description><subject>adults</subject><subject>breakfast cereals</subject><subject>cross-over studies</subject><subject>Enteroinsular axis</subject><subject>glucagon-like peptide 1</subject><subject>glucose</subject><subject>hay</subject><subject>haylage</subject><subject>Horse</subject><subject>Incretin</subject><subject>insulin</subject><subject>Insulin dysregulation</subject><subject>insulin resistance</subject><subject>intravenous injection</subject><subject>Laminitis</subject><subject>pathophysiology</subject><subject>secretin</subject><issn>1090-0233</issn><issn>1532-2971</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EoqXwBxiQR5YUfyWNJRZU8VGpEgudLcc5F5c0DnZa0X-PqxZGmO50eu493YPQNSVjSmhxtxr321UzZoSJNCgoJSdoSHPOMiYn9DT1RJKMMM4H6CLGFSFECsHO0YCXBRGcsyFazNotxN4tde98i73Fy2Zj9NK3WeM-AHfQ9a6GjOIAsfNtBNx7HN0X9kE32OhQ-fddHXQPEbsWJ8RBvERnVjcRro51hBZPj2_Tl2z--jybPswzk673GZiaCyu1tRMiSlsawQqZc9A1AVnnVmtTUZPnEtJTEko7KTgwUeXEsopawUfo9pDbBf-5SX-otYsGmka34DdR8WRjkvzkxf8o4aVgpZAsoeyAmuBjDGBVF9xah52iRO3Nq5Xam1d78-pgPi3dHPM31Rrq35Uf1Qm4PwCQhGwdBBWNg9ZA7QKYXtXe_ZX_Db2XlQs</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Carslake, H.B.</creator><creator>Pinchbeck, G.L.</creator><creator>Argo, C.M.</creator><creator>Dugdale, A.H.A.</creator><creator>McGowan, C.M.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20240601</creationdate><title>Investigation of glucagon-like peptide-1 response to six oral carbohydrates in ponies</title><author>Carslake, H.B. ; Pinchbeck, G.L. ; Argo, C.M. ; Dugdale, A.H.A. ; McGowan, C.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-ecd34f9aff7048f8c426953ead0e9d5faacb1c559e5329e8f763e24b50f2b1f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>adults</topic><topic>breakfast cereals</topic><topic>cross-over studies</topic><topic>Enteroinsular axis</topic><topic>glucagon-like peptide 1</topic><topic>glucose</topic><topic>hay</topic><topic>haylage</topic><topic>Horse</topic><topic>Incretin</topic><topic>insulin</topic><topic>Insulin dysregulation</topic><topic>insulin resistance</topic><topic>intravenous injection</topic><topic>Laminitis</topic><topic>pathophysiology</topic><topic>secretin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carslake, H.B.</creatorcontrib><creatorcontrib>Pinchbeck, G.L.</creatorcontrib><creatorcontrib>Argo, C.M.</creatorcontrib><creatorcontrib>Dugdale, A.H.A.</creatorcontrib><creatorcontrib>McGowan, C.M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carslake, H.B.</au><au>Pinchbeck, G.L.</au><au>Argo, C.M.</au><au>Dugdale, A.H.A.</au><au>McGowan, C.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of glucagon-like peptide-1 response to six oral carbohydrates in ponies</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>305</volume><spage>106110</spage><pages>106110-</pages><artnum>106110</artnum><issn>1090-0233</issn><issn>1532-2971</issn><eissn>1532-2971</eissn><abstract>Glucagon-like peptide-1 (GLP-1), the principal incretin in horses, may play a role in the pathophysiology of insulin dysregulation (ID). This study aimed to describe its concentration in response to three preserved forages and four dynamic tests for ID in ponies. Twelve adult ponies of mixed ID status were given a meal of hay, soaked hay or haylage, an in-feed oral glucose test (OGT), oral sugar test (OST), an oral test using a proprietary breakfast cereal (WEET) or a combined glucose-insulin tolerance test (CGIT) weekly in a randomised cross-over study. Glucose, insulin and GLP-1 concentrations were measured before and following each intervention. Ponies were designated ID or non-ID and insulin resistant (IR) or non-IR according to OGT and CGIT results, respectively.
All interventions apart from the CGIT provoked a GLP-1 response within 30 min. The OGT and WEET interventions, (containing the greatest dose of non-structural carbohydrate, 1.06 and 1 g/kg BW, respectively), resulted in a greater area under the curve (AUC) for GLP-1 compared to all other interventions (P < 0.001). No difference in GLP-1 response was detected according to ID or IR status, despite there being strong positive correlations (rs [95 % CI]) between GLP-1 and insulin concentrations measured at individual time points (0.67 [0.62 – 0.71]; P < 0.001) and as AUC (0.66 [0.49–0.79], P < 0.001). These data do not support of the use of GLP-1 as an adjunctive diagnostic test for ID or IR, as defined by conventional intravenous or oral dynamic tests.
•Glucagon-like peptide-1 (GLP-1) was detected within 30 min of oral carbohydrates.•GLP-1 response was associated with dose of non-structural carbohydrate.•Soaking hay resulted in a decreased GLP-1 response.•GLP-1 and insulin responses were correlated.•Insulin dysregulation status did not affect GLP-1 response.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38604332</pmid><doi>10.1016/j.tvjl.2024.106110</doi><oa>free_for_read</oa></addata></record> |
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| subjects | adults breakfast cereals cross-over studies Enteroinsular axis glucagon-like peptide 1 glucose hay haylage Horse Incretin insulin Insulin dysregulation insulin resistance intravenous injection Laminitis pathophysiology secretin |
| title | Investigation of glucagon-like peptide-1 response to six oral carbohydrates in ponies |
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