Revealing the graded activation mechanism of neurotensin receptor 1

Graded activation contributes to the precise regulation of GPCR activity, presenting new opportunities for drug design. In this work, a total of 10 μs enhanced-sampling simulations are performed to provide molecular insights into the binding dynamics differences of the neurotensin receptor 1 (NTSR1)...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of biological macromolecules 2024-10, Vol.278 (Pt 1), p.134488, Article 134488
Hauptverfasser:	Wu, Zhixiang, Sun, Xiaohan, Su, Jingjie, Zhang, Xinyu, Hu, Jianping, Li, Chunhua
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists dissociation drug design entropy GPCR Graded activation ligands MD simulation neurotensin signal transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!