Farnesol prevents chlorpyrifos nephrotoxicity by modulating inflammatory mediators, Nrf2 and FXR and attenuating oxidative stress

Chlorpyrifos (CPF) is a broad-spectrum insecticide widely employed in agricultural field for pest control. Exposure to CPF is associated with serious effects to the main organs, including kidneys. Significant evidence denotes that oxidative stress (OS) and inflammation are implicated in CPF toxicity...

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Veröffentlicht in:	Food and chemical toxicology 2024-08, Vol.190, p.114788, Article 114788
Hauptverfasser:	Alruhaimi, Reem S., Alotaibi, Mohammed F., Alnasser, Sulaiman M., Alzoghaibi, Mohammed A., Germoush, Mousa O., Alotaibi, Meshal, Hassanein, Emad H.M., Mahmoud, Ayman M.
Format:	Artikel
Sprache:	eng
Schlagworte:	agricultural land animal models Animals antioxidants Antioxidants - pharmacology apoptosis blood caspase-3 chlorpyrifos Chlorpyrifos - toxicity computer simulation creatinine farnesol Farnesol - pharmacology histopathology Inflammation Inflammation Mediators - metabolism Insecticides - toxicity Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - prevention & control kidneys Male Nephrotoxicity NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects pest control Pesticides Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear - metabolism Sesquiterpene urea
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