The plant immune system: From discovery to deployment
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to specific pathogen isolates over 100 years ago. Subsequent breedi...
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| Veröffentlicht in: | Cell 2024-04, Vol.187 (9), p.2095-2116 |
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| container_title | Cell |
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| creator | Jones, Jonathan D.G. Staskawicz, Brian J. Dangl, Jeffery L. |
| description | Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to specific pathogen isolates over 100 years ago. Subsequent breeding for disease resistance underpins modern agriculture and, along with the emergence and focus on model plants for genetics and genomics research, has provided rich resources for molecular biological exploration over the last 50 years. These studies led to the identification of extracellular and intracellular receptors that convert recognition of extracellular microbe-encoded molecular patterns or intracellular pathogen-delivered virulence effectors into defense activation. These receptor systems, and downstream responses, define plant immune systems that have evolved since the migration of plants to land ∼500 million years ago. Our current understanding of plant immune systems provides the platform for development of rational resistance enhancement to control the many diseases that continue to plague crop production.
Plant diseases significantly impact human and environmental health. This review encompasses the last 50 years of research in the plant immune system, an overview of the pathogen virulence proteins, and strategies for durable resistance. |
| doi_str_mv | 10.1016/j.cell.2024.03.045 |
| format | Article |
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Plant diseases significantly impact human and environmental health. This review encompasses the last 50 years of research in the plant immune system, an overview of the pathogen virulence proteins, and strategies for durable resistance.</description><subject>climate change</subject><subject>crop production</subject><subject>disease resistance</subject><subject>Disease Resistance - genetics</subject><subject>effector proteins</subject><subject>ETI</subject><subject>genomics</subject><subject>Humans</subject><subject>immigration</subject><subject>immune system</subject><subject>immune system evolution</subject><subject>pathogen recognition</subject><subject>pathogens</subject><subject>Plant Diseases - immunology</subject><subject>Plant Diseases - microbiology</subject><subject>Plant Immunity - genetics</subject><subject>plant immunology</subject><subject>plant inflammasome</subject><subject>Plants - genetics</subject><subject>Plants - immunology</subject><subject>PTI</subject><subject>receptor systems</subject><subject>resistosomes</subject><subject>sustainable agriculture</subject><subject>virulence</subject><subject>virulence factors</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMoWi8v4EJm6WbGk3tH3EixKghuug-Z5AxOmUtNZgp9e1OqLnUVOPn-n3M-Qq4pFBSoulsXDtu2YMBEAbwAIY_IjEKpc0E1OyYzgJLlc6XFGTmPcQ0AcynlKTnjaQig9IzI1Qdmm9b2Y9Z03dRjFndxxO4-W4ahy3wT3bDFsMvGIfO4aYddh_14SU5q20a8-n4vyGr5tFq85G_vz6-Lx7fcCc7HHCtd1p5TWlZiLr0ola0pY67GWslKMukddbQCAcAsswhqXtcqfQqqrLf8gtweajdh-JwwjqZL-6SbbY_DFA2nkmuqNGP_oyB0KTkVOqHsgLowxBiwNpvQdDbsDAWzF2vWZp80e7EGuEliU-jmu3-qOvS_kR-TCXg4AJh8bBsMJroGe4e-CehG44fmr_4vxb-IpQ</recordid><startdate>20240425</startdate><enddate>20240425</enddate><creator>Jones, Jonathan D.G.</creator><creator>Staskawicz, Brian J.</creator><creator>Dangl, Jeffery L.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-4953-261X</orcidid></search><sort><creationdate>20240425</creationdate><title>The plant immune system: From discovery to deployment</title><author>Jones, Jonathan D.G. ; Staskawicz, Brian J. ; Dangl, Jeffery L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-eb79fd3119b485d496af122cfef65b525dc1c1b04002a2ae068ff6ef6416ada3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>climate change</topic><topic>crop production</topic><topic>disease resistance</topic><topic>Disease Resistance - genetics</topic><topic>effector proteins</topic><topic>ETI</topic><topic>genomics</topic><topic>Humans</topic><topic>immigration</topic><topic>immune system</topic><topic>immune system evolution</topic><topic>pathogen recognition</topic><topic>pathogens</topic><topic>Plant Diseases - immunology</topic><topic>Plant Diseases - microbiology</topic><topic>Plant Immunity - genetics</topic><topic>plant immunology</topic><topic>plant inflammasome</topic><topic>Plants - genetics</topic><topic>Plants - immunology</topic><topic>PTI</topic><topic>receptor systems</topic><topic>resistosomes</topic><topic>sustainable agriculture</topic><topic>virulence</topic><topic>virulence factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Jonathan D.G.</creatorcontrib><creatorcontrib>Staskawicz, Brian J.</creatorcontrib><creatorcontrib>Dangl, Jeffery L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Jonathan D.G.</au><au>Staskawicz, Brian J.</au><au>Dangl, Jeffery L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The plant immune system: From discovery to deployment</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2024-04-25</date><risdate>2024</risdate><volume>187</volume><issue>9</issue><spage>2095</spage><epage>2116</epage><pages>2095-2116</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. 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Plant diseases significantly impact human and environmental health. This review encompasses the last 50 years of research in the plant immune system, an overview of the pathogen virulence proteins, and strategies for durable resistance.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38670067</pmid><doi>10.1016/j.cell.2024.03.045</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0002-4953-261X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | climate change crop production disease resistance Disease Resistance - genetics effector proteins ETI genomics Humans immigration immune system immune system evolution pathogen recognition pathogens Plant Diseases - immunology Plant Diseases - microbiology Plant Immunity - genetics plant immunology plant inflammasome Plants - genetics Plants - immunology PTI receptor systems resistosomes sustainable agriculture virulence virulence factors |
| title | The plant immune system: From discovery to deployment |
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